Zobrazeno 1 - 10 of 13 pro vyhledávání: '"G O, Rankin"'
2
Hypertensive factor in different models of experimental hypertension
Autor: Elsa I. Mangiarua, Gary L. Wright, G. O. Rankin, William D. McCumbee
Publikováno v: Archives Internationales de Physiologie, de Biochimie et de Biophysique. 99:309-313
A hypertensive factor (HF), isolated from rat erythrocytes, has been shown to stimulate in vitro calcium uptake in aortic rings and to elevate blood pressure when injected into normotensive rats. In the present study, we investigated tissue responsiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c6a6a1d81ca02f4dc55171ea40edba
https://doi.org/10.3109/13813459109146942
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3
Synthesis and anticonvulsant activity of enaminones. 3. Investigations on 4'-, 3'-, and 2'-substituted and polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluations
Autor: K R, Scott, G O, Rankin, J P, Stables, M S, Alexander, I O, Edafiogho, V A, Farrar, K R, Kolen, J A, Moore, L D, Sims, A D, Tonnu
Publikováno v: Journal of medicinal chemistry. 38(20)
In a continuing evaluation of the aniline-substituted enaminones, the synthesis of additional para-substituted analogs has been made in an attempt to further quantify the electronic (sigma) and lipophilic (pi) requirements for anticonvulsant activity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d7a6727452c25df1f712fb17a3f59cc
https://pubmed.ncbi.nlm.nih.gov/7562939
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4
The effects of cobalt chloride, SKF-525A, and N-(3,5-dichlorophenyl)succinimide on in vivo hepatic mixed function oxidase activity as determined by single-sample plasma clearances
Autor: M. S. Madhira, Kenneth Bachmann, G. O. Rankin
Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 22(1)
1. Four drugs--antipyrine, theophylline, quinidine, and ethosuximide--were used as probes of in vivo hepatic mixed function oxidase (MFO) activity. Functional MFO activity was evaluated by estimating probe clearances subsequent to pretreatment of rat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5ee2bf7638905b05bc3cf9ef983b8c
https://pubmed.ncbi.nlm.nih.gov/1615705
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5
An antihypertensive extract of erythrocytes: effects on 45Ca uptake and efflux
Autor: Gary L. Wright, G. O. Rankin, William D. McCumbee
Publikováno v: Canadian Journal of Physiology and Pharmacology. 64:424-429
The present report describes some aspects of the effects of a recently described antihypertensive extract of erythrocytes (AHF) on calcium uptake and efflux in rat aortae. AHF was found to be present in the erythrocytes of both spontaneously hyperten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf4a76292ddca2fa8774ec008ad9a1a
https://doi.org/10.1139/y86-068
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6
Concentrations of ionic and total calcium in plasma of four models of hypertension
Autor: G. L. Wright, G. O. Rankin
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 243:H365-H370
The levels of ionic calcium in whole blood obtained from female Sprague-Dawley (SDR). Wistar-Kyoto (WKY), and spontaneously hypertensive (SHR) rate tended to decrease between 5 and 13 wk of age. During this interval the plasma total calcium levels of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8eb047b4265b6b07b65b48047f088b
https://doi.org/10.1152/ajpheart.1982.243.3.h365
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7
An antihypertensive substance associated with erythrocytes
Autor: G. O. Rankin, Gary L. Wright, W. D. McCumbee
Publikováno v: The American journal of physiology. 248(4 Pt 2)
An extract was prepared from hemolyzed erythrocytes of spontaneously hypertensive rats (SHR) which inhibits lanthanum-resistant calcium uptake by aortic segments and lowers blood pressure in several models of hypertension. Erythrocyte hemolysates wer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b285096e3e3419f37f553e04771d3e9
https://pubmed.ncbi.nlm.nih.gov/3985170
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9
Development of tolerance to guanethidine in three hypertensive rat models
Autor: G O, Rankin, B E, Watkins, D G, Sawutz
Publikováno v: Archives internationales de pharmacodynamie et de therapie. 271(2)
The development of tolerance to the antihypertensive effects of guanethidine was determined in one-kidney one clip and two-kidney one clip renovascular hypertensive rats and spontaneously hypertensive rats (SHR). The effect of gender on the tolerance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c841967b99c96931bc0a417d22a90986
https://pubmed.ncbi.nlm.nih.gov/6508434
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10
Effects of captopril on the development of tolerance to guanethidine
Autor: G O, Rankin, G J, Haas
Publikováno v: Federation proceedings. 43(5)
Guanethidine is a sympatholytic antihypertensive drug used for the treatment of severe or resistant hypertension. Previous clinical studies have documented the development of tolerance to guanethidine in humans and suggested that fluid retention or i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30606ef4511e7f188e7cd6d37ea6e2c3
https://pubmed.ncbi.nlm.nih.gov/6323227
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