Zobrazeno 1 - 10
of 12
pro vyhledávání: '"G O, Chandler"'
Autor:
Richard A. Mumford, H. Weston, Alan L. Maycock, Shrenik K. Shah, Bonnie M. Ashe, Karen A. Brause, James B. Doherty, G. O. Chandler, Paul E. Finke
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2295-2298
The synthesis of the four stereoisomers of 3-ethyl-4-[(4-carboxyphenyl)oxy]-1-[[(phenylmethyl)amino]carbonyl]-2-azetidinone ( 1 ) starting from either D or L-aspartic acid is reported. The trans (3R,4R) isomer 7a , prepared from L-aspartic acid had t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b75117a32415cd53baebdaf78cd7344e
https://doi.org/10.1016/s0960-894x(01)80942-2
https://doi.org/10.1016/s0960-894x(01)80942-2
Autor:
G. O. Chandler, P. E. Finke, J. B. Doherty, Karen A. Brause, H. Weston, W. B. Knight, S. K. Shah, Bonnie M. Ashe, Alan L. Maycock
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b37db752caf301bac0ae85a711ebdb6
https://doi.org/10.1002/chin.199108338
https://doi.org/10.1002/chin.199108338
Autor:
Thomas J. Blacklock, Laura A. O'Grady, C. P. Jun. Dorn, G. O. Chandler, Raymond A. Firestone, Peter L. Barker, Kevan R. Thompson, Mary Ellen Dahlgren, Alan L. Maycock, Bonnie M. Ashe, Manuel A. Navia, S. K. Shah, W. B. Knight, P. Davies, Judith M. Pisano, Morris Zimmerman, W. K. Hagmann, J. B. Doherty, John W. Butcher, P. E. Finke, H. Weston, T. Halgren
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7821159f7592fd1fd3d97f4b9eac6366
https://doi.org/10.1002/chin.199108336
https://doi.org/10.1002/chin.199108336
Autor:
S. K. Shah, H. Weston, W. K. Hagmann, Richard A. Mumford, Karen A. Brause, J. B. Doherty, D. S. Fletcher, W. B. Knight, C. P. Jun. Dorn, Dennis J. Underwood, Pam S. Dellea, J. J. Hale, Amy L. Kissinger, P. E. Finke, Karen M. Hand, Alan L. Maycock, Bonnie M. Ashe, G. O. Chandler
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6974db53a20907e71079b428ba03f87
https://doi.org/10.1002/chin.199320171
https://doi.org/10.1002/chin.199320171
Autor:
J. B. Doherty, P. Davies, P. E. Finke, H. Weston, Bonnie M. Ashe, G. O. Chandler, Pam S. Dellea, S. K. Shah, Karen M. Hand, Alan L. Maycock, Donald G. Osinga, Karen A. Brause, D. S. Fletcher, Dennis J. Underwood
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c741805b01f7e6580595e315b68fb9da
https://doi.org/10.1002/chin.199542123
https://doi.org/10.1002/chin.199542123
Autor:
S K, Shah, C P, Dorn, P E, Finke, J J, Hale, W K, Hagmann, K A, Brause, G O, Chandler, A L, Kissinger, B M, Ashe, H, Weston
Publikováno v:
Journal of Medicinal Chemistry. 35:3745-3754
A thorough analysis of the mechanism of inhibition of human leukocyte elastase (HLE) by a monocyclic beta-lactam and the mechanism of beta-lactam hydrolysis led to the preparation of potent and highly stable inhibitors of HLE. This work led to the id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451b2a8391952e9d8f09c0837d3d5f01
https://doi.org/10.1021/jm00099a003
https://doi.org/10.1021/jm00099a003
Autor:
P E, Finke, S K, Shah, D S, Fletcher, B M, Ashe, K A, Brause, G O, Chandler, P S, Dellea, K M, Hand, A L, Maycock, D G, Osinga
Publikováno v:
Journal of medicinal chemistry. 38(13)
The stereospecific synthesis of several 4-[(4-carboxyphenyl)oxy]- 3,3-dialkyl-1-[[(1-phenylalkyl)-amino]carbonyl]azetidin-2-on es 3 is described in which the C-3 alkyl groups were varied from methyl to butyl as well as allyl, benzyl and methoxymethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebdef0ce68c406e499072b2524cf1be
https://pubmed.ncbi.nlm.nih.gov/7608910
https://pubmed.ncbi.nlm.nih.gov/7608910
Autor:
Kevan R. Thompson, P. E. Finke, Karen A. Brause, J. B. Doherty, Amy L. Kissinger, C P Dorn, Shrenik K. Shah, J J Hale, William K. Hagmann, G. O. Chandler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 90(18)
A series of potent and highly selective time-dependent monocyclic beta-lactam inhibitors of human polymorphonuclear leukocyte elastase (PMNE, EC 3.4.21.37) is described. The intrinsic potency of these compounds, as exemplified by L-680,833 (k(inactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75cb5f634e4b88f377a6e461c75e3d2
https://pubmed.ncbi.nlm.nih.gov/8378355
https://pubmed.ncbi.nlm.nih.gov/8378355
Autor:
Thomas J. Blacklock, Philip Davies, Richard G. Ball, Karen A. Brause, R. J. Bonney, P. E. Finke, M Cotton, Bonnie M. Ashe, G. O. Chandler, S. K. Shah
Publikováno v:
Journal of medicinal chemistry. 35(21)
Human leukocyte elastase (HLE) is a serine protease which has been implicated as a causative agent in several pulmonary diseases. The continued modification of our previously reported cephalosporin-based HLE inhibitors has led to the identification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9887b138fa53b88a0048809a71d2419
https://pubmed.ncbi.nlm.nih.gov/1433188
https://pubmed.ncbi.nlm.nih.gov/1433188
Autor:
Bonnie M. Ashe, H. Weston, W. B. Knight, Shrenik K. Shah, Paul E. Finke, Alan L. Maycock, Karen A. Brause, G. O. Chandler, James B. Doherty
Publikováno v:
Journal of medicinal chemistry. 33(9)
Several 3'-substituted cephalosporin sulfones were synthesized from 3-(hydroxymethyl)cephalosporin, which was prepared by Ti(OiPr)4 hydrolysis of the corresponding acetate. A method was also developed to prepare a 3-vinylcephalosporin. Some of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93407f7f6da15346356589bd8bc7d6a
https://pubmed.ncbi.nlm.nih.gov/2391693
https://pubmed.ncbi.nlm.nih.gov/2391693