Zobrazeno 1 - 10
of 18
pro vyhledávání: '"G N, Apryshko"'
Publikováno v:
Russian Journal of Bioorganic Chemistry. 44:322-329
2,3-Indolotriterpenic alcohols have been synthesized for the first time by successive modification of 3-oxo triterpenic acids (Fisher reaction, reduction of С17-СOOH, cyanoethylation) and characterized by physicochemical methods of analysis. It has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9ccfd9c17ce11920c2a39583a4ceea9
https://doi.org/10.1134/s1068162018030081
https://doi.org/10.1134/s1068162018030081
Publikováno v:
Russian Journal of Bioorganic Chemistry. 44:123-127
New propargylamines were synthesized in 72–75% yields by the interaction of 19-alkynylbetulin and 28-O-propargyl glycinamide of oleanolic acid with N-methylpiperazine under the Mannich reaction conditions. 19-[1-Methyl-4-prop-2-yn-1-yl-piperazine]-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50f78222ad0fb2ba1cd56f8e83cb3c94
https://doi.org/10.1134/s1068162018010090
https://doi.org/10.1134/s1068162018010090
Autor:
O. V. Goryunova, G. N. Apryshko, L. V. Fetisova, R. B. Pugacheva, O. S. Zhukova, N. K. Vlasenkova
Publikováno v:
Russian Journal of Biotherapy. 16:46-54
Objective: to evaluate the prospects of the glycosides of indolocarbazole containing amino acid residues as potential antitumor compounds. Materials and methods. For 32 compounds by structural formulas using the methods of chemoinformatics, a number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d41e8dafd904ef0b010363c7e2b90cf9
https://doi.org/10.17650/1726-9784-2017-16-4-46-54
https://doi.org/10.17650/1726-9784-2017-16-4-46-54
Autor:
Rujena B. Pugacheva, Nadejda P. Yavorskaya, Irina S. Golubeva, G. N. Apryshko, Vladimir Poroikov, Olga S. Zhukova, Oxana B. Kazakova, Gulnara V. Giniyatyllina, I. E. Smirnova
Publikováno v:
Medicinal Chemistry Research. 24:3423-3436
Triterpenoids with aminopropoxy groups in C-28 or C-3 and C-28 positions were synthesized from betulin, erythrodiol, uvaol, oleantriol and betulinic acid N-methylpiperazinylamide by cyanoethylation and the following catalytic hydrogenolysis. Computat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc4f456acb80f34fc2a44344364fc5f5
https://doi.org/10.1007/s00044-015-1392-y
https://doi.org/10.1007/s00044-015-1392-y
Autor:
T. V. Lopatina, Nadejda P. Yavorskaya, N. I. Medvedeva, Irina S. Golubeva, G. N. Apryshko, Oxana B. Kazakova, Tolstikov Genrikh A, Rujena B. Pugacheva
Publikováno v:
Russian Journal of Bioorganic Chemistry. 41:305-314
Synthesis of lupane C28-imidazolides, contained 3-oxo-, 3-oximino- and 2-cyano-2,3-seco-4(23)-en-frag ments in cycle A was carried out. The most antitumor activity at. in vitro testing showed 3-oximino-lup- 20(29)-en-28-yl-1H-imidazole-1-carboxylate;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3a3c8b4ffcdf9f6544a01b581379bf9
https://doi.org/10.1134/s1068162015020065
https://doi.org/10.1134/s1068162015020065
Autor:
Lucjusz Zaprutko, G. V. Giniyatullina, G. N. Apryshko, I. P. Baikova, Oxana B. Kazakova, Tolstikov Genrikh A
Publikováno v:
Russian Journal of Bioorganic Chemistry. 37:369-379
Aminopropoxy derivatives of betulin, erythrodiol, uvaol, and oleantriol have been synthesized by the cyanoethylation of the hydroxyl groups of triterpenoids with the subsequent reduction of cyanoethyl fragments. It has been found that 3β,28-di-O-[3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e711c982d6401d519575da8a96dadb7
https://doi.org/10.1134/s1068162011030101
https://doi.org/10.1134/s1068162011030101
Publikováno v:
Automatic Documentation and Mathematical Linguistics. 43:286-291
Approaches to the standard presentation of the structural formulae of substances in the anticancer drug database of the Blokhin RCRC, RAMS have been described. These approaches provide the maximum appropriate use of the formulae in systems of biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6b10f376f2fba00a86cf3df948ad354
https://doi.org/10.3103/s0005105509050045
https://doi.org/10.3103/s0005105509050045
Autor:
G. N. Apryshko
Publikováno v:
Automatic Documentation and Mathematical Linguistics. 41:217-225
The structure of the biological module of the computer database in the ISIS/Base format of the Information System for Antitumor Agents of the GU Blokhin Cancer Research Center (CRC), RAMS, is given and the organizational and technological aspects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c962c1fb5e382b2d5f84a8ac46c7ea1
https://doi.org/10.3103/s0005105507050068
https://doi.org/10.3103/s0005105507050068
Autor:
G. N. Apryshko
Publikováno v:
Automatic Documentation and Mathematical Linguistics. 41:6-10
A general description of the corporate information system for antitumor agents of the Blokhin Cancer Research Center (CRC), a complex representing an archive of primary documents, paper cards with formalized information, and a computer database in IS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca0fc13fc0edb0e6d3a2c0b982e6e885
https://doi.org/10.3103/s0005105507010025
https://doi.org/10.3103/s0005105507010025
Autor:
O B, Kazakova, N I, Medvedeva, T V, Lopatina, G N, Apryshko, R B, Pugacheva, N P, Yavorskaya, I S, Golubeva, G A, Tolstikov
Publikováno v:
Bioorganicheskaia khimiia. 41(3)
Synthesis of lupane C28-imidazolides, contained 3-oxo-, 3-oximino- and 2-cyano-2,3-seco-4(23)-en-frag ments in cycle A was carried out. The most antitumor activity at. in vitro testing showed 3-oximino-lup- 20(29)-en-28-yl-1H-imidazole-1-carboxylate;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::02f5aa027a681a6fd787a8f2a96f0d7d
https://pubmed.ncbi.nlm.nih.gov/26502611
https://pubmed.ncbi.nlm.nih.gov/26502611