Zobrazeno 1 - 10
of 549
pro vyhledávání: '"G McLaren"'
Autor:
Benjamin B. Sun, Stephanie J. Loomis, Fabrizio Pizzagalli, Natalia Shatokhina, Jodie N. Painter, Christopher N. Foley, Biogen Biobank Team, Megan E. Jensen, Donald G. McLaren, Sai Spandana Chintapalli, Alyssa H. Zhu, Daniel Dixon, Tasfiya Islam, Iyad Ba Gari, Heiko Runz, Sarah E. Medland, Paul M. Thompson, Neda Jahanshad, Christopher D. Whelan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Genetic associations with particular patterns of brain folding may provide insight into brain development and function. Here, the authors identify and replicate 388 genetic associations with brain sulcal morphology across 40,169 UK Biobank MRI scans,
Externí odkaz:
https://doaj.org/article/6a31732e43d94e97bac89d4842fe34f4
Autor:
Menglin Chen, Zhengrong Zhu, Tom Wisniewski, Xiaoping Zhang, David G. McLaren, Adam Weinglass, S. Adrian Saldanha
Publikováno v:
SLAS Discovery, Vol 27, Iss 7, Pp 405-412 (2022)
Study of small molecule binding to live cells provides important information on the characterization of ligands pharmacologically. Here we developed and validated a label-free, liquid chromatography-mass spectrometry (LC-MS) based cell binding assay,
Externí odkaz:
https://doaj.org/article/692086835e5a4837a6ecf8d1a559ee73
Autor:
Santhosh Satapati, Daniel P. Downes, Daniel Metzger, Harish Shankaran, Saswata Talukdar, Yingjiang Zhou, Zhao Ren, Michelle Chen, Yeon-Hee Lim, Nathan G. Hatcher, Xiujuan Wen, Payal R. Sheth, David G. McLaren, Stephen F. Previs
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 20-28 (2022)
Screening campaigns, especially those aimed at modulating enzyme activity, often rely on measuring substrate→product conversions. Unfortunately, the presence of endogenous substrates and/or products can limit one's ability to measure conversions. A
Externí odkaz:
https://doaj.org/article/103ba40a3e5a45859c5af8ed7bf87a21
Autor:
Adway O. Zacharias, Chang Liu, Zachary L. VanAernum, Thomas R. Covey, Kevin P. Bateman, Xiujuan Wen, David G. McLaren
Publikováno v:
Journal of the American Society for Mass Spectrometry. 34:4-9
The need for high-throughput intact protein analysis has been rising as drug discovery increasingly requires the analysis of large sets of covalent modifiers and protein therapeutics. Liquid chromatography-mass spectrometry (LC-MS) is the primary ana
Autor:
Ji Zhang, Eric S. Muise, Seongah Han, Peter S. Kutchukian, Philippe Costet, Yonghua Zhu, Yanqing Kan, Haihong Zhou, Vinit Shah, Yongcheng Huang, Ashmita Saigal, Taro E. Akiyama, Xiao-Lan Shen, Tian-Quan Cai, Kashmira Shah, Ester Carballo-Jane, Emanuel Zycband, Lan Yi, Ye Tian, Ying Chen, Jason Imbriglio, Elizabeth Smith, Kristine Devito, James Conway, Li-Jun Ma, Maarten Hoek, Iyassu K. Sebhat, Andrea M. Peier, Saswata Talukdar, David G. McLaren, Stephen F. Previs, Kristian K. Jensen, Shirly Pinto
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056- (2020)
Summary: Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, a
Externí odkaz:
https://doaj.org/article/063a70c64d8f4793abcfad76e4a93d9a
Autor:
Huifang Yao, Bingming Chen, Paul Harradine, Bahanu Habulihaz, David G. McLaren, Mark T. Cancilla
Publikováno v:
Journal of the American Society for Mass Spectrometry.
Autor:
Kristian K. Jensen, Marija Tadin-Strapps, Sheng-ping Wang, James Hubert, Yanqing Kan, Yong Ma, David G. McLaren, Stephen F. Previs, Kithsiri B. Herath, Ablatt Mahsut, Andy Liaw, Shubing Wang, Steven J. Stout, CarolAnn Keohan, Gail Forrest, David Coelho, Satya Yendluri, Stephanie Williams, Martin Koser, Steven Bartz, Karen O. Akinsanya, Shirly Pinto
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 12, Pp 2150-2162 (2016)
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2. SREBPs regulate the exp
Externí odkaz:
https://doaj.org/article/bd0a1abbb701431196775362cf9f8457
Autor:
David G. McLaren, Stephen F. Previs, Robert D. Phair, Steven J. Stout, Dan Xie, Ying Chen, Gino M. Salituro, Suoyu S. Xu, Jose M. Castro-Perez, Gregory J. Opiteck, Karen O. Akinsanya, Michele A. Cleary, Hayes M. Dansky, Douglas G. Johns, Thomas P. Roddy
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 3, Pp 398-409 (2016)
Studies in lipoprotein kinetics almost exclusively rely on steady-state approaches to modeling. Herein, we have used a non-steady-state experimental design to examine the role of cholesteryl ester transfer protein (CETP) in mediating HDL-TG flux in v
Externí odkaz:
https://doaj.org/article/5fbca9dec0944cbaae6bb25b8975fe09
Publikováno v:
South African Journal of Science, Vol 111, Iss 1/2, Pp 1-9 (2015)
We report the first quantum entanglement experiment in South Africa. The spatial modes of the entangled photon pair were investigated with their potential for high-dimensional entanglement. The generation, measurement and characterisation of the enta
Externí odkaz:
https://doaj.org/article/a4beab43c3644c4eaea8e13e80c3005d
Autor:
Lazar A. Bojic, David G. McLaren, Vinit Shah, Stephen F. Previs, Douglas G. Johns, Jose M. Castro-Perez
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 23283-23293 (2014)
The cellular, macromolecular and neutral lipid composition of the atherosclerotic plaque has been extensively characterized. However, a comprehensive lipidomic analysis of the major lipid classes within atherosclerotic lesions has not been reported.
Externí odkaz:
https://doaj.org/article/e4031e0296f244e98a7e32850d24aea0