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Aggregate formation is more strongly inhibited at high shear rates by dRGDW, a synthetic RGD-containing peptide

Autor: E. U. M. Saelman, P. G. De Groot, J. J. Sixma, G. Marguerie, K. M. Hese, H. K. Nieuwenhuis, I. Cavero, Andre Uzan

Publikováno v: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 13:1164-1170

The effect of D-Arg-Gly-Asp-Trp (dRGDW), a synthetic RGD-containing peptide, on platelet adhesion and aggregate formation on various purified adhesive proteins and the extracellular matrix of endothelial cells was investigated with anticoagulated blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b030b11ca50ba1d3ed0d92751d049c6b
https://doi.org/10.1161/01.atv.13.8.1164

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Inhibition of Platelet Adhesion to Fibrin(ogen) in Flowing Whole Blood by Arg-Gly-Asp and Fibrinogen γ-Chain Carboxy Terminal Peptides

Autor: Andre Uzan, G. Marguerie, P. G. De Groot, Roy R. Hantgan, S. C. Endenburg, Jan J. Sixma, I. Cavero

Publikováno v: Thrombosis and Haemostasis. 68:694-700

SummaryWe have employed synthetic peptides with sequences corresponding to the integrin receptor-recognition regions of fibrinogen as inhibitors of platelet aggregation and adhesion to fibrinogen-and fibrin-coated surfaces in flowing whole blood, usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69eb299e55d7f979c9476a83b43d9836
https://doi.org/10.1055/s-0038-1646346

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Thrombasthenic mice generated by replacement of the integrin alpha(IIb) gene: demonstration that transcriptional activation of this megakaryocytic locus precedes lineage commitment

Autor: D, Tronik-Le Roux, V, Roullot, C, Poujol, T, Kortulewski, P, Nurden, G, Marguerie

Publikováno v: Blood. 96(4)

To analyze the transcriptional activity of the gene encoding the alpha subunit of the platelet integrin alpha(IIb)beta(3) during the hematopoietic differentiation, mice were produced in which the herpes virus thymidine kinase (tk) was introduced in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a1bc3bba1a389a3a90bd5c0c0555a47
https://pubmed.ncbi.nlm.nih.gov/10942384

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Ultrastructural analysis of bone marrow hematopoiesis in mice transgenic for the thymidine kinase gene driven by the alpha IIb promoter

Autor: C, Poujol, D, Tronik-Le Roux, P, Tropel, V, Roullot, A, Nurden, G, Marguerie, P, Nurden

Publikováno v: Blood. 92(6)

Transgenic mice have been generated with expression of the herpes virus thymidine kinase gene directed by a 2.7-kb fragment of the alphaIIb murine promoter of the gene encoding the alphaIIb-subunit of the platelet integrin alphaIIbbeta3 (Tropel et al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afe628ad30e977128ae36c657c1ec0fe
https://pubmed.ncbi.nlm.nih.gov/9731059

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A 2.7-kb portion of the 5' flanking region of the murine glycoprotein alphaIIb gene is transcriptionally active in primitive hematopoietic progenitor cells

Autor: P, Tropel, V, Roullot, M, Vernet, C, Poujol, H, Pointu, P, Nurden, G, Marguerie, D, Tronik-Le Roux

Publikováno v: Blood. 90(8)

The continuous generation of mature blood cells from primitive multipotent progenitor cells requires a highly complex series of cellular events that are still largely unknown. To examine the molecular events associated with the commitment of these he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a7e52241057488d1189fa1a87e7bc59
https://pubmed.ncbi.nlm.nih.gov/9376580

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Conference

Hafit period fuelwood preferences associated with early copper production at Building V, al-Khashbah, Oman.

Autor: PROCTOR, LUCAS¹ proctor@em.uni-frankfurt.de, DÖPPER, STEPHANIE² stephanie.doepper@hcch.uni-heidelberg.de, SCHMIDT, CONRAD³ conrad.schmidt@uni-tuebingen.de

Publikováno v: Proceedings of the Seminar for Arabian Studies. 2024, Vol. 53, p230-247. 18p.

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Inhibition of platelet adhesion to fibrin(ogen) in flowing whole blood by Arg-Gly-Asp and fibrinogen gamma-chain carboxy terminal peptides

Autor: R R, Hantgan, S C, Endenburg, I, Cavero, G, Marguerie, A, Uzan, J J, Sixma, P G, de Groot

Publikováno v: Thrombosis and haemostasis. 68(6)

We have employed synthetic peptides with sequences corresponding to the integrin receptor-recognition regions of fibrinogen as inhibitors of platelet aggregation and adhesion to fibrinogen- and fibrin-coated surfaces in flowing whole blood, using a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::442b98e280940878da10e6d95506370d
https://pubmed.ncbi.nlm.nih.gov/1287884

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Characterization of a specific erythromegakaryocytic enhancer within the glycoprotein IIb promoter

Autor: M H, Prandini, G, Uzan, F, Martin, D, Thevenon, G, Marguerie

Publikováno v: The Journal of biological chemistry. 267(15)

The gene coding for glycoprotein IIb (GPIIb), the alpha subunit of platelet integrin GPIIb/IIIa is an early and specific marker of the megakaryocytic lineage. Thus, studies on the regulation of this gene may provide helpful information on the mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::deae60cf1f7e750cf27cd826dcaed879
https://pubmed.ncbi.nlm.nih.gov/1587823

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