Zobrazeno 1 - 10
of 81
pro vyhledávání: '"G Marcela, Rodriguez"'
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT The dioxonaphthoimidazolium scaffold is a novel, highly bactericidal redox cycling antituberculosis chemotype that is reliant on the respiratory enzyme Type II NADH dehydrogenase (NDH2) for the generation of reactive oxygen species (ROS). He
Externí odkaz:
https://doaj.org/article/1e5c6baba743469489cb102c6f5f8064
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Most pathogenic bacteria require iron for growth. However, this metal is not freely available in the mammalian host. Due to its poor solubility and propensity to catalyze the generation of reactive oxygen species, host iron is kept in solution bound
Externí odkaz:
https://doaj.org/article/8ea1047e480c4a26a4dbeecbc821fe1a
Autor:
Krishna Kurthkoti, Hamel Amin, Mohlopheni J. Marakalala, Saleena Ghanny, Selvakumar Subbian, Alexandra Sakatos, Jonathan Livny, Sarah M. Fortune, Michael Berney, G. Marcela Rodriguez
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT This study was conducted to investigate the role of iron deprivation in the persistence of Mycobacterium tuberculosis. We present evidence of iron restriction in human necrotic granulomas and demonstrate that under iron starvation M. tubercu
Externí odkaz:
https://doaj.org/article/9ea9094635ae48e2a25c39feefe73d81
Publikováno v:
Mol Immunol
The production of extracellular vesicles (EVs) has emerged as an important process in bacterial biology and host-pathogen interactions. Like many other bacteria, mycobacteria, including Mycobacterium tuberculosis (Mtb), the causative agent of human t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e0663e5306dfc3a9fbf4e18870d6cd
https://doi.org/10.1016/j.molimm.2021.02.010
https://doi.org/10.1016/j.molimm.2021.02.010
Publikováno v:
Journal of Immunology Research, Vol 2015 (2015)
Mycobacterium tuberculosis the causative agent of tuberculosis affects millions of people worldwide. New tools for treatment and prevention of tuberculosis are urgently needed. We previously showed that a ferritin (bfrB) mutant of M. tuberculosis has
Externí odkaz:
https://doaj.org/article/ef1e0e68ce9642019180c8d1445a3c2d
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/af2369ff377c48f2816744c3a95d0e66
The ESX-3 secretion system is necessary for iron and zinc homeostasis in Mycobacterium tuberculosis.
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78351 (2013)
ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis viability and proposed its involvement in iron and zinc metabolism. In this study w
Externí odkaz:
https://doaj.org/article/b23dea5938134925a0c45ce9b9e34318
Autor:
Navneet Dogra, Matthew B. Neiditch, Shamba Gupta, David Gil, Juan Anguita, José Luis Lavín, Leticia Sampedro, Brian Weinrick, M. Carmen Menéndez, Ainhoa Palacios, Rafael Prados-Rosales, G. Marcela Rodriguez, M. Jesus García, Atul Khataokar
Mycobacterium tuberculosis (Mtb) secretes pathogenicity factors and immunologically active molecules via membrane vesicles. However, nothing is known about the mechanisms involved in mycobacterial vesicle biogenesis. This study investigates molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c18b762ec45583ed0664c2bc48eba93
Autor:
G. Marcela Rodriguez, Shamba Gupta
Publikováno v:
Journal of visualized experiments : JoVE. (152)
Mycobacteria, including Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, naturally release extracellular vesicles (EVs) containing immunologically active molecules. Knowledge regarding the molecular mechanisms of vesicle b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220d5507acd5cdfe5f85d01f5ec1bf89
https://pubmed.ncbi.nlm.nih.gov/31736487
https://pubmed.ncbi.nlm.nih.gov/31736487
Publikováno v:
Journal of Clinical Medicine, Vol 8, Iss 8, p 1155 (2019)
Journal of Clinical Medicine
Volume 8
Issue 8
Journal of Clinical Medicine
Volume 8
Issue 8
The human response to Mycobacterium tuberculosis (Mtb) infection is affected by the availability of iron (Fe), which is necessary for proper immune cell function and is essential for the growth and virulence of bacteria. Increase in host Fe levels pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d0ab9517260284364bd3ac01dae044
https://www.mdpi.com/2077-0383/8/8/1155
https://www.mdpi.com/2077-0383/8/8/1155