Chaperones and Catalysts: How Antigen Presentation Pathways Cope With Biological Necessity

Autor: David H. Margulies, Daniel K. Taylor, Jiansheng Jiang, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Kannan Natarajan

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Immune recognition by T lymphocytes and natural killer (NK) cells is in large part dependent on the identification of cell surface MHC molecules bearing peptides generated from either endogenous (MHC I) or exogenous (MHC II) dependent pathways. This

Externí odkaz: https://doaj.org/article/4f2ff701293a4c0aac80f4c8856fbb79

The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling

Autor: Kannan Natarajan, Jiansheng Jiang, Nathan A. May, Michael G. Mage, Lisa F. Boyd, Andrew C. McShan, Nikolaos G. Sgourakis, Ad Bax, David H. Margulies

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Antigen presentation is a cellular process that involves a number of steps, beginning with the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides to cellular compartments where they are loaded on MHC class I (MHC

Externí odkaz: https://doaj.org/article/b399f764e4124bf6b9d60d4c3f366d5f

Rabbit models of human diseases for diagnostics and therapeutics development

Autor: Rose G. Mage, Christoph Rader, Pedro J. Esteves

Publikováno v: Developmental & Comparative Immunology. 92:99-104

This review presents some examples of studies using the European rabbit (Oryctolagus cuniculus) that have led to, and continue to, contribute to advancement of understanding of human diseases as well as therapeutics development. In addition, we tabul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d8e99762af400a78ecd4f69e82089d
https://doi.org/10.1016/j.dci.2018.10.003

Dynamic features of tapasin as revealed by structures of two tapasin/Fab complexes

Autor: Daniel Kyle Taylor, Jiansheng Jiang, Lisa F Boyd, Peter Cresswell, Michael G Mage, David H Margulies, Kannan Natarajan

Publikováno v: The Journal of Immunology. 208:102.20-102.20

Intracellular loading of major histocompatibility complex class I (MHC-I) molecules occurs within the peptide loading complex and is accomplished through the concerted action of several proteins, including the chaperone/catalyst tapasin. In the absen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5c5464a7f7de6661ff5aefc0f47fafb
https://doi.org/10.4049/jimmunol.208.supp.102.20

The wide utility of rabbits as models of human diseases

Autor: Xiang-Peng Kong, Jacques Le Pendu, Selvakumar Subbian, Dennis K. Lanning, Ana M. Lopes, Natalie Ruvoën-Clouet, Katherine L. Knight, Joana Abrantes, Javier González-Gallego, Xuwen Peng, Lbachir BenMohamed, Ana Acacia S. Pinheiro, Michael Vaine, Lorenzo Giacani, Rose G. Mage, Neil D. Christensen, Wessel van der Loo, Shuying Liu, Pedro J. Esteves, María J. Tuñón, Fabiana Neves, Masmudur M. Rahman, Yuxing Chen, Hanna Mari Baldauf, Ana Lemos de Matos, Ruimin Pan, Jia Liu, Laura E. Via, Patrícia de Sousa-Pereira, Jiafen Hu, Shixia Wang, Oliver T. Keppler, Grant McFadden, Shan Lu, Sheila A. Lukehart, Gilla Kaplan, Yukari C. Manabe

Publikováno v: Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 50, Iss 5, Pp 1-10 (2018)
Experimental & Molecular Medicine, Nature Publishing Group, 2018, 50 (5), pp.66. ⟨10.1038/s12276-018-0094-1⟩
Experimental & Molecular Medicine, 2018, 50 (5), pp.66. ⟨10.1038/s12276-018-0094-1⟩

Studies using the European rabbit Oryctolagus cuniculus contributed to elucidating numerous fundamental aspects of antibody structure and diversification mechanisms and continue to be valuable for the development and testing of therapeutic humanized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c459be79159418ee67bb00756f31e7
https://doi.org/10.1038/s12276-018-0094-1