Zobrazeno 1 - 10
of 15
pro vyhledávání: '"G M Trakshel"'
Autor:
Christopher Thomas Brain, Kristy Chung, Markus Vögtle, Ming Xu, Yipin Lu, Hong Cheng, James M. Groarke, Marc O'Reilly, Ying Hou, Chen Christine Hiu-Tung, Mei Xu, Steven Kovats, Moo Je Sung, Troy Smith, Sunkyu Kim, G M Trakshel, Young Shin Cho, He Guo, Junqing Shen, Maria Borland, Rajiv Chopra
Publikováno v:
Journal of Medicinal Chemistry. 53:7938-7957
Identification and structure-guided optimization of a series of 4-(pyrazol-4-yl)-pyrimidines as selective CDK4/6 inhibitors is reported herein. Several potency and selectivity determinants were established based on the X-ray crystallographic analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ca1084815aeaf5b1449a83ece0ad7a
https://doi.org/10.1021/jm100571n
https://doi.org/10.1021/jm100571n
Publikováno v:
International Journal of Mass Spectrometry and Ion Processes. :201-215
MALDI mass spectrometry has been used to study the conjugation of two small molecules to hen egg white lysozyme and human serum albumin. Hapten densities were determined with both proteins. Synthetic peptide mixtures, designed to eliminate the need f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2828fb17ef2f48adeb65f53debaf8e61
https://doi.org/10.1016/s0168-1176(97)00206-1
https://doi.org/10.1016/s0168-1176(97)00206-1
Autor:
Mahin D. Maines, G M Trakshel
Publikováno v:
Archives of Biochemistry and Biophysics. 300:320-326
Conversion of biliverdin to bilirubin is catalyzed by the cytosolic enzyme biliverdin reductase. We have purified and characterized the human liver reductase and find it to differ extensively from the previously described rat enzyme (H. Fakhrai and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2913c5d3fcd842f3423bc1292b905e27
https://doi.org/10.1006/abbi.1993.1044
https://doi.org/10.1006/abbi.1993.1044
Publikováno v:
Biochemical Journal. 275:159-164
In Cebus apella monkey, as with other mammalian species tested to date, two different forms of haem oxygenase, HO-1 and HO-2, are detected. With the use of cDNA fragment corresponding to HO-1 nucleotides +71 to +833, blot hybridization of RNA reveale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f534b7de2ac6a2d496073844a46ce7
https://doi.org/10.1042/bj2750159
https://doi.org/10.1042/bj2750159
Autor:
M D, Maines, G M, Trakshel
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 260(2)
The present investigation provides evidence of the ability of Sn-protoporphyrin to cause striking alterations in adrenal and testicular cytochrome P-450-dependent steroidogenesis and defines the potential of this metalloporphyrin to serve as a cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a57c7a664acbe3520405b86b65487ffc
https://pubmed.ncbi.nlm.nih.gov/1371161
https://pubmed.ncbi.nlm.nih.gov/1371161
Detection of 10 variants of biliverdin reductase in rat liver by two-dimensional gel electrophoresis
Publikováno v:
Journal of Biological Chemistry. 264:7844-7849
We have identified and characterized multiple forms of biliverdin reductase (BVR) in control rat liver cytosol. Two-dimensional electrophoresis of the purified BVR resolved a minimum of 10 discrete protein zones. All 10 proteins were BVR as judged by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73a2446451053026823faec35349f20e
https://doi.org/10.1016/s0021-9258(18)83119-2
https://doi.org/10.1016/s0021-9258(18)83119-2
Autor:
Mahin D. Maines, G M Trakshel
Publikováno v:
Journal of Biological Chemistry. 264:1323-1328
We report on the detection and characterization of two forms of heme oxygenase in rabbit tissues and provide data suggesting that heme oxygenases in rat and rabbit are not identical and constitute a group of heterogenous proteins. Certain molecular p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f2c5dd09de7eda1624a68cd1dab0768
https://doi.org/10.1016/s0021-9258(19)85089-5
https://doi.org/10.1016/s0021-9258(19)85089-5
Publikováno v:
Journal of Biological Chemistry. 261:11131-11137
Recently we reported on the presence of two isoforms of heme oxygenase in rat liver microsomes, referred to as HO-1 and HO-2, and that only HO-1 is inducible (Maines, M. D., Trakshel, G. M., and Kutty, R. K. (1986) J. Biol. Chem. 261, 411-419). Prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9843249ef9ef3e2ec9e708a9238db16c
https://doi.org/10.1016/s0021-9258(18)67358-2
https://doi.org/10.1016/s0021-9258(18)67358-2
Publikováno v:
Journal of Biological Chemistry. 261:411-419
The present report describes, for the first time, the identification of two constitutive forms of heme oxygenase, designated as HO-1 and HO-2, in rat liver microsomal fractions. HO-1 was purified to homogeneity and exhibited a specific activity of up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c295855bfa3e3da722c7400655108b7
https://doi.org/10.1016/s0021-9258(17)42488-4
https://doi.org/10.1016/s0021-9258(17)42488-4
Autor:
G M, Trakshel, M D, Maines
Publikováno v:
The Journal of biological chemistry. 264(2)
We report on the detection and characterization of two forms of heme oxygenase in rabbit tissues and provide data suggesting that heme oxygenases in rat and rabbit are not identical and constitute a group of heterogenous proteins. Certain molecular p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c2b002f9ed50952bcf234a003e6e9e0
https://pubmed.ncbi.nlm.nih.gov/2910857
https://pubmed.ncbi.nlm.nih.gov/2910857