Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Autor: Catarina F. Almeida, Srinivasan Sundararaj, Jérôme Le Nours, T. Praveena, Benjamin Cao, Satvika Burugupalli, Dylan G. M. Smith, Onisha Patel, Manfred Brigl, Daniel G. Pellicci, Spencer J. Williams, Adam P. Uldrich, Dale I. Godfrey, Jamie Rossjohn

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Natural killer T (NKT) cells include type I that express semi-invariant T cell receptor (TCR), and type II that cover a broader repertoire. Here the authors describe the crystal structure of a type II NKT TCR complexed with CD1d/antigen to propose th

Externí odkaz: https://doaj.org/article/d1409e5d6e6042d8b4b0882766610142

A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease

Autor: Annie Latif, Arunima Mukhopadhyay, Mhairi Copland, Fiona Thomson, Dragana Milojkovic, Letizia Foroni, G. M. Smith, Jenny Byrne, Gillian A. Horne, Paolo Gallipoli, Philippe Schafhausen, Judith Dixon-Hughes, Franck E. Nicolini, P. Cony-Makhoul, Richard E. Clark, Wenjuan Cong, Gudmundur Vignir Helgason, Jon Stobo, Steffen Koschmieder, T H Brümmendorf, Lynn McMahon, Caroline Kelly, Tessa L. Holyoake

Publikováno v: Leukemia
LEUKEMIA
Horne, G, Stobo, J, Kelly, C, Mukhopadhyay, A, Latif, A, Dixon, J, McMahon, L, Cony-Makhoul, P, Byrne, J, Smith, G, Koschmieder, S, BrÜmmendorf, T, Schafhausen, P, Gallipoli, P, Thomson, F, Cong, W, Clark, R, Milojkovic, D, Helgason, V, Foroni, L, NICOLINI, F-E, Holyoake, T & Copland, M 2020, ' A randomised Phase II trial of Hydroxychloroquine and Imatinib versus Imatinib alone for patients with Chronic Myeloid Leukaemia in Major Cytogenetic Response with residual disease ', Leukemia . https://doi.org/10.1038/s41375-019-0700-9

1 In chronic-phase chronic myeloid leukaemia (CP-CML), residual BCR-ABL1+ leukaemia stem cells are 2 responsible for disease persistence despite TKI. Based on in vitro data, CHOICES (CHlorOquine and 3 Imatinib Combination to Eliminate Stem cells) was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24af8c15119e8a2c9bc14fffc509365b
http://europepmc.org/articles/PMC7224085

Ambivalence in the Christian poetry of C.S. Lewis

Autor: G. M. Smith

Publikováno v: Literator, Vol 20, Iss 1, Pp 15-30 (1999)

This article examines the ambivalence expressed in certain of the explicitly Christian poems written by C.S. Lewis. As a writer his primary claim to fame is his Christian apologetics, in spite of the fact that he is well thought of in literary circle

Externí odkaz: https://doaj.org/article/676eeca4b49f42d3a8fe5f64773cf74b

A British Society for Haematology guideline on the diagnosis and management of chronic myeloid leukaemia

Autor: Jamshid S. Khorashad, Adam J. Mead, Chris Plummer, Gail Jones, Mhairi Copland, Wendy Osborne, Dragana Milojkovic, Jenny Byrne, Jane F. Apperley, Letizia Foroni, Anupama Rao, G. M. Smith, Andy Goringe, Nicholas C.P. Cross, Hugues de Lavallade

The management of chronic myeloid leukaemia (CML) has seen considerable change in the last several years. The objective of this guideline is to provide healthcare professionals with clear guidance on the investigation and management of CML in adults

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13f0041aa52863cd87371502cc10838
https://eprints.soton.ac.uk/442801/

Topographical classification of dose distributions: implications for control for worker exposure

Autor: K Siegien, N. K. Shandala, A Ksenofontov, Drozdovitch, A. G. Tsov’yanov, G M Smith, Konstantin Chizhov, A Kryanev, Malgorzata Sneve, A Krasnoschekov, Yu Bragin, Victor Kryuchkov, Tesnov I

Publikováno v: J Radiol Prot

This paper deals with classification of dose distributions of nuclear workers based on antikurtosis (Q) and entropy coefficients (K) and their relationship presented in QK-diagrams. It is shown that determination of the most appropriate distribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0902458efa38e75ea03d30d279661a37
https://pubmed.ncbi.nlm.nih.gov/31968313