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AGP/EBP(LAP) expressed in rat hepatoma cells interacts with multiple promoter sites and is necessary for maximal glucocorticoid induction of the rat alpha-1 acid glycoprotein gene

Autor: T. Ratajczak, G. M. Ringold, P. M. Williams, S. C. Lee

Publikováno v: Molecular and Cellular Biology. 11:4959-4965

Transcription of the rat alpha 1-acid glycoprotein (AGP) gene is induced by glucocorticoids. In addition to the glucocorticoid response element which maps to bases -120 to -107, sequences located between bases -106 to -42 have been shown to be necess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac66d888ee0cfff7491ddb64a4ac8639
https://doi.org/10.1128/mcb.11.10.4959

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Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90

Autor: Edwin R. Sanchez, G. M. Ringold, William B. Pratt, Hsin-Yi Tang, M. Hirst, J. M. Harmon, S. Stoney Simons, Michael J. Welsh, Lawrence C. Scherrer

Publikováno v: Journal of Biological Chemistry. 265:20123-20130

In this work, we examine the cellular localization and protein interactions of mouse glucocorticoid receptors that have been overexpressed in Chinese hamster ovary (CHO) cells (Hirst, M. A., Northrop, J. P., Danielsen, M., and Ringold, G. M. (1990) M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2da739c384ff31f162956869c6292257
https://doi.org/10.1016/s0021-9258(17)30478-7

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Evidence that the conserved region in the steroid binding domain of the glucocorticoid receptor is required for both optimal binding of hsp90 and protection from proteolytic cleavage. A two-site model for hsp90 binding to the steroid binding domain

Autor: E R Sanchez, G M Ringold, Paul R. Housley, Mark Danielsen, W B Pratt

Publikováno v: Journal of Biological Chemistry. 265:12778-12781

Steroid hormone receptors contain a conserved sequence of amino acids within the steroid binding domain, and we have previously speculated that this conserved region is the site of interaction of the glucocorticoid receptor with hsp90 (Danielsen, M.,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4997ea226e7ebd31701563b6d010e438
https://doi.org/10.1016/s0021-9258(19)38225-0

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TNF alpha-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARgamma without effects on Pref-1 expression

Autor: H Xing, J L Su, K E Kilpatrick, J R Grove, J P Northrop, G M Ringold

Publikováno v: Endocrinology. 138(7)

Tumor necrosis factor alpha (TNF alpha) is a polypeptide hormone with pleiotropic effects on cellular proliferation and differentiation. To investigate how TNF alpha inhibits and reverses adipocyte differentiation, we studied the expression of two fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edb7c101151a565d25e7d3b1763318d
https://pubmed.ncbi.nlm.nih.gov/9202217

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Multiple elements within the glucocorticoid regulatory unit of the rat alpha 1-acid glycoprotein gene are recognition sites for C/EBP

Autor: T, Ratajczak, P M, Williams, D, DiLorenzo, G M, Ringold

Publikováno v: The Journal of biological chemistry. 267(16)

Sequences between -106 and -42, located immediately downstream of the glucocorticoid response element, are essential for efficient glucocorticoid-stimulated expression of the alpha 1-acid glycoprotein (AGP) gene. We have used mobility shift assays wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2b3ee5175c9ab2de72b53b29227174f
https://pubmed.ncbi.nlm.nih.gov/1597449

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Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C/EBP) and C/EBP-like proteins interact with sequences required for differentiation-dependent expression

Autor: W Hoeck, G M Ringold, U Danesch

Publikováno v: Europe PubMed Central

We have reported previously the cloning of several cDNAs whose mRNAs are induced during differentiation of the adipogenic cell line TA1. Here we characterize an adipocyte-specific gene, which we refer to as FSP27 (formerly clone 47), that encodes a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60efcf8df53ed9d844b4a367de2ac675
https://pubmed.ncbi.nlm.nih.gov/1339452

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Resistance to killing by tumor necrosis factor in an adipocyte cell line caused by a defect in arachidonic acid biosynthesis

Autor: T, Reid, C S, Ramesha, G M, Ringold

Publikováno v: The Journal of biological chemistry. 266(25)

We have found that TA1-R6, which are resistant to the cytotoxic effects of tumor necrosis factor (TNF) in the presence of cycloheximide (Reid, T. R., Torti, F., and Ringold, G. M. (1989) J. Biol. Chem. 264, 4583-4589), have reduced ability to release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77b8e9dffd8b489d7170e646534498b9
https://pubmed.ncbi.nlm.nih.gov/1909330

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Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90

Autor: E R, Sanchez, M, Hirst, L C, Scherrer, H Y, Tang, M J, Welsh, J M, Harmon, S S, Simons, G M, Ringold, W B, Pratt

Publikováno v: The Journal of biological chemistry. 265(33)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7d7e46e1d20cecfffa42aa927c524e9
https://pubmed.ncbi.nlm.nih.gov/2243084

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Autor: P R, Housley, E R, Sanchez, M, Danielsen, G M, Ringold, W B, Pratt

Publikováno v: The Journal of biological chemistry. 265(22)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9334ebd889dee73af83502e8cca746b6
https://pubmed.ncbi.nlm.nih.gov/2376573

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Evidence for two mechanisms by which tumor necrosis factor kills cells

Autor: F M Torti, G M Ringold, T R Reid

Publikováno v: Journal of Biological Chemistry. 264:4583-4589

Tumor necrosis factor (TNF) can inhibit the differentiation of preadipocytes to adipocytes and will revert differentiated adipocytes to the preadipocyte state. TNF is not toxic to either adipocytes or preadipocytes when used alone but is highly toxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0874ffbc4f6ff877ae7d0785adab35ac
https://doi.org/10.1016/s0021-9258(18)83783-8

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