Zobrazeno 1 - 10
of 26
pro vyhledávání: '"G M Gibb"'
Autor:
Andrew J. Grierson, James Connell, Peter L. Lantos, G M Gibb, Diane P. Hanger, Teresa Rodriguez-Martin, N.M. Kahn, Jean-Marc Gallo, Tamas Revesz, Brian H. Anderton
Publikováno v:
Molecular Brain Research. 137:104-109
A number of neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by intraneuronal accumulation of the tau protein. Some forms of FTDP-17 are caused by mutations in the tau gene affecting exon 10 splicing. Therefore, dysre
Autor:
Andrew D. Hope, Rina Bandopadhyay, Andrew J. Lees, R de Silva, G M Gibb, Brian H. Anderton, C Strand, T Jowett, T Revesz, Nicola Wood, Nadeem A. Khan, Tammaryn Lashley, Diane P. Hanger, JL Holton, Andrew R. Reid, Michelle A. Utton
Publikováno v:
Neuropathology and Applied Neurobiology. 29:288-302
Pathological inclusions containing fibrillar aggregates of hyperphosphorylated tau protein are a characteristic feature in the tauopathies, which include Alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17)
Autor:
G M Gibb, Walter P. Blackstock, Jean-Marc Gallo, Simon Lovestone, Brian H. Anderton, Joanna Betts, James Connell, Mike Hutton
Publikováno v:
FEBS Letters. 493:40-44
In vitro phosphorylation of recombinant wild-type 2N4R tau and FTDP-17 exonic mutant forms P301L, V337M and R406W by glycogen synthase kinase 3beta (GSK3beta) was examined by two dimensional phosphopeptide mapping analysis on thin layer cellulose pla
Autor:
Brian H. Anderton, Michael M. Hoffmann, Simon Lovestone, Winfried Maerz, Joanna C. Betts, G M Gibb, Walter P. Blackstock, J. Pearce
Publikováno v:
FEBS Letters. 485:99-103
Previously published data have shown an allele-specific variation in the in vitro binding of apolipoprotein E (apoE) to tau, which prompted the hypothesis that apoE binding may protect tau from phosphorylation, apoE3 being more efficient than apoE4.
Autor:
Peter M. Bayley, C. H. Reynolds, U. Wagner, G. M. Gibb, B.H. Anderton, André Vandecandelaere, M. A. Utton, Christopher C.J. Miller
Publikováno v:
Biochemical Journal. 323:741-747
To study the effects of phosphorylation by glycogen synthase kinase-3β (GSK-3β) on the ability of the microtubule-associated protein tau to promote microtubule self-assembly, tau isoform 1 (foetal tau) and three mutant forms of this tau isoform wer
Publikováno v:
Methods in molecular medicine. 32
Tau was originally isolated from brain microtubules and shown to be a microtubule-associated protein (MAP) that promoted tubulin polymerization (1). It is largely confined to axons, where it is the major MAP. It promotes microtubule nucleation, elong
Publikováno v:
Biochemical Journal. 265:903-906
Products of the mitochondrial genome were identified in the bovine kidney cell line NBL-1 by labelling with [35S]methionine in the presence of cycloheximide. Seven proteins were precipitated by an antiserum to bovine heart NADH dehydrogenase, corresp
Tau was originally isolated from brain microtubules and shown to be a microtubule-associated protein (MAP) that promoted tubulin polymerization (1). It is largely confined to axons, where it is the major MAP. It promotes microtubule nucleation, elong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::241aef35e2dc058038b6ce0838a71ee5
https://doi.org/10.1385/1-59259-195-7:375
https://doi.org/10.1385/1-59259-195-7:375
Publikováno v:
Brain research. Molecular brain research. 121(1-2)
We found previously that aggregated insoluble tau protein in progressive supranuclear palsy (PSP) brains exhibits a heterogeneous pattern that is not segregated by the type of clinical presentation. Here we have investigated tau isoform composition f
Autor:
Andrew Makoff, Susan Chapman, Paul W. Sheppard, Claire L. Pollard, Amritpal Mudher, Abdur-Rasheed Asuni, L Raymond, Patrick A. Lewis, J Richardson, H T Rupniak, Todd E. Golde, Richard Killick, Brian H. Anderton, E Gower, Simon Lovestone, G M Gibb, T Iqbal, Matthew C. Murphy, Ian M. Varndell, P E Soden
Publikováno v:
Scopus-Elsevier
Alzheimer's disease (AD) is a disorder of two pathologies: amyloid plaques, the core of which is a peptide derived from the amyloid precursor protein (APP), and neurofibrillary tangles composed of highly phosphorylated tau. Protein kinase C (PKC) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26097ca1fd751feb26abfe3664db298
https://europepmc.org/articles/PMC6762860/
https://europepmc.org/articles/PMC6762860/