Zobrazeno 1 - 10
of 30
pro vyhledávání: '"G M Chisolm"'
Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7 beta-hydroperoxycholesterol
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 9, Pp 2018-2028 (1996)
The relative toxicities of several lipid oxidation products formed on oxidized LDL, their presence on oxidized LDL, and potential mechanisms of cell injury compared to oxidized LDL were examined. Toxicities to fibroblasts, with lipoprotein-deficient
Externí odkaz:
https://doaj.org/article/b331e0857e464de4b005c65f8957bbd7
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 9, Pp 1857-1865 (1995)
Upon activation, human peripheral blood monocytes and U937 cells oxidized low density lipoprotein (LDL), converting it to a cytotoxin. The oxidized LDL loses its ability to interact specifically with the native LDL (apoB/E) receptor and becomes a lig
Externí odkaz:
https://doaj.org/article/807769f4e92b4bde926dce2a419c8607
Publikováno v:
Journal of Lipid Research, Vol 24, Iss 8, Pp 1070-1076 (1983)
Low density lipoprotein (LDL) has been reported to be injurious or toxic to cells in vitro. This injurious effect is, in some instances, due to oxidation of the lipid moiety of the lipoprotein. The objectives of this study were to determine if the ox
Externí odkaz:
https://doaj.org/article/6b263a47f1d24f9abcdf83e56d319c58
Autor:
D W Morel, G M Chisolm
Publikováno v:
Journal of Lipid Research, Vol 30, Iss 12, Pp 1827-1834 (1989)
Increased lipid peroxidation products were detected in a lipoprotein fraction containing very low density lipoprotein (VLDL) and low density lipoprotein (LDL) obtained from rats made diabetic by streptozotocin injection. The enhanced oxidation in the
Externí odkaz:
https://doaj.org/article/0aa0dc38dee847afa138e6b00a83e297
Publikováno v:
The Journal of Immunology. 145:254-259
Monocyte-mediated oxidation of low-density lipoprotein (LDL) converts the lipoprotein to a potent cytotoxin. The oxidation process requires monocyte activation and requires superoxide anion since it can be blocked by superoxide dismutase. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8745ca1e78b87c70d4096ce6b7d370c5
https://doi.org/10.4049/jimmunol.145.1.254
https://doi.org/10.4049/jimmunol.145.1.254
Publikováno v:
The Journal of Immunology. 144:2343-2350
In the present report we have examined expression of the gene encoding the inflammatory monokine TNF-alpha in murine peritoneal macrophages treated with different forms of low density lipoprotein (LDL). LDL modified by oxidation in vitro is unable to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b41fa29002686d8c3b31ea30d46718c5
https://doi.org/10.4049/jimmunol.144.6.2343
https://doi.org/10.4049/jimmunol.144.6.2343
Publikováno v:
Blood. 96(9)
Tissue factor, which is expressed in vascular lesions, increases thrombin production, blood coagulation, and smooth muscle cell proliferation. We demonstrate that oxidized low-density lipoprotein (LDL) induces surface tissue factor pathway activity (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::995998f88b59823878666fc06a4b50fe
https://pubmed.ncbi.nlm.nih.gov/11049984
https://pubmed.ncbi.nlm.nih.gov/11049984
Autor:
S M, Colles, G M, Chisolm
Publikováno v:
Journal of lipid research. 41(8)
Lysophosphatidylcholine (lysoPC), formed during LDL oxidation and located within atherosclerotic plaques, induces numerous cellular responses, but via unknown mechanisms. Cellular events involved in sublethal lysoPC-induced injury were examined becau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::735fc7ee1a3b239f44d2ffacff916db4
https://pubmed.ncbi.nlm.nih.gov/10946005
https://pubmed.ncbi.nlm.nih.gov/10946005
Publikováno v:
The Journal of biological chemistry. 274(37)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d116bbfc9de290a1fad27eddd113a919
https://pubmed.ncbi.nlm.nih.gov/10473535
https://pubmed.ncbi.nlm.nih.gov/10473535
Publikováno v:
The Journal of biological chemistry. 271(30)
We have previously shown that oxidized low density lipoprotein (LDL) but not native LDL stimulated DNA synthesis in cultured smooth muscle cells (SMC) and that alpha-tocopherol (vitamin E) inhibited this proliferative response (Lafont, A., Chai, Y. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b185340d5fe143ffe2ea853f2804a14
https://pubmed.ncbi.nlm.nih.gov/8663300
https://pubmed.ncbi.nlm.nih.gov/8663300