Výsledky vyhledávání

Safety and immunogenicity of meningococcal A and C polysaccharide conjugate vaccine in adults

Autor: D J Kennedy, G M Carlone, T Bowers, H Harakeh, P Holder, Edwin L. Anderson, L Pais, ChrisAnna M. Mink, Robert B. Belshe

Publikováno v: Infection and Immunity. 62:3391-3395

A meningococcal vaccine containing group A and C polysaccharides conjugated to CRM197 was evaluated in 50 adults. Vaccinees were entered into one of five groups: 30 adults received a single dose of either 22, 11, or 5.5 micrograms of the conjugated A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dece672a61b6b0ad4c3be8a78bc47135
https://doi.org/10.1128/iai.62.8.3391-3395.1994

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Serogroup B and C serum bactericidal assays

Autor: R, Borrow, G M, Carlone

Publikováno v: Methods in molecular medicine. 66

Meningococci are usually classified based on serological reactivity of their polysaccharide capsules with serogroups A, B, and C, currently the most common causes of disease. Serogroup A meningococci can cause massive outbreaks particularly in areas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d02531c6a02b4081dbca0e9789af2a3
https://pubmed.ncbi.nlm.nih.gov/21336762

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Stable, conserved outer membrane epitope of strains of Haemophilus influenzae biogroup aegyptius associated with Brazilian purpuric fever

Autor: S D Myers, G M Carlone, L L Gheesling, W E Bittner, Alan J. Lesse

Publikováno v: Infection and Immunity. 60:1351-1357

Brazilian purpuric fever is a rapidly fatal childhood disease associated with a clonal strain of Haemophilus influenzae biogroup aegyptius. We describe a conserved, surface-exposed epitope present on 95% of H. influenzae biogroup aegyptius isolates t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaad26477ce245c318926a75a7e42fc4
https://doi.org/10.1128/iai.60.4.1351-1357.1992

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Distribution of Neisseria meningitidis serogroup B serosubtypes and serotypes circulating in the United States. The Active Bacterial Core Surveillance Team

Autor: M L, Tondella, T, Popovic, N E, Rosenstein, D B, Lake, G M, Carlone, L W, Mayer, B A, Perkins

Publikováno v: Journal of clinical microbiology. 38(9)

Because the Neisseria meningitidis serogroup B (NMSB) capsule is poorly immunogenic in humans, immunization strategies have focused on noncapsular antigens. Both PorA and to a lesser extent PorB are noncapsular protein antigens capable of inducing pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6217f8aa394dfb5bea89b9d69670ad9c
https://pubmed.ncbi.nlm.nih.gov/10970378

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Baculovirus expression, purification and evaluation of recombinant pneumococcal surface adhesin A of Streptococcus pneumoniae

Autor: B K, De, J S, Sampson, E W, Ades, S E, Johnson, A R, Stinson, J, Crook, J A, Tharpe, R C, Huebner, G M, Carlone

Publikováno v: Pathobiology : journal of immunopathology, molecular and cellular biology. 67(3)

Pneumococcal surface adhesin A (PsaA), with a molecular mass of approximately 37 kD by SDS-PAGE, is a common surface protein expressed by all 90 serotypes of Streptococcus pneumoniae. S. pneumoniae serotype 6B genomic DNA was amplified to generate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b22d9280a5ce99169b529da0a52c206
https://pubmed.ncbi.nlm.nih.gov/10394131

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Safety and immunogenicity of a serogroups A/C Neisseria meningitidis oligosaccharide-protein conjugate vaccine in young children. A randomized controlled trial

Autor: J M, Lieberman, S S, Chiu, V K, Wong, S, Partidge, S J, Chang, C Y, Chiu, L L, Gheesling, G M, Carlone, J I, Ward

Publikováno v: JAMA. 275(19)

To assess the safety and immunogenicity of a bivalent serogroups A/C meningococcal oligosaccharide-protein conjugate vaccine compared with the licensed meningococcal polysaccharide vaccine.Randomized controlled trial.Ninety healthy 18- to 24-month-ol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::933a580338d9eb25854f34c64e758160
https://pubmed.ncbi.nlm.nih.gov/8622225

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Antibody response after immunization of Brazilian children with serogroup C meningococcal polysaccharide noncovalently complexed with outer membrane proteins

Autor: L G, Milagres, A P, Lemos, C E, Meles, E L, Silva, L H, Ferreira, J A, Souza, G M, Carlone

Publikováno v: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 28(9)

We have studied the antibody response of Brazilian vaccinees to C meningococcal polysaccharide (C-PS) after one or two doses of a vaccine composed of C-PS, outer membrane proteins of B meningococci and aluminum hydroxide. Total IgG, IgG1 and IgG2 as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b28631415ac2432a75ffb704b1c7ff52
https://pubmed.ncbi.nlm.nih.gov/8580887

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A trial of a group A plus group C meningococcal polysaccharide-protein conjugate vaccine in African infants

Autor: P A, Twumasi, S, Kumah, A, Leach, T J, O'Dempsey, S J, Ceesay, J, Todd, C V, Broome, G M, Carlone, L B, Pais, P K, Holder

Publikováno v: The Journal of infectious diseases. 171(3)

The safety and immunogenicity of a group A plus group C meningococcal polysaccharide-CRM197 conjugate vaccine was evaluated in 304 8- to 10-week-old Gambian infants. Infants were immunized with one, two, or three doses of conjugate vaccine or with tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75c5c7d8ede3f791796b9fbc9cb4cf75
https://pubmed.ncbi.nlm.nih.gov/7876610

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