Výsledky vyhledávání - "G M, Shutske"

Identification of the urinary metabolites of tacrine in the rat

Autor: R S, Hsu, G M, Shutske, E M, Dileo, S M, Chesson, A R, Linville, R C, Allen

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 18(5)

Tacrine (THA) is a potent cholinesterase inhibitor being studied for the treatment of Alzheimer's disease. The metabolism and excretion of THA were studied in rats following a single oral dose of 20 mg/kg of THA. The results show THA was extensively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef84c395dd8bb8dd9469f7bb4f3a2820
https://pubmed.ncbi.nlm.nih.gov/1981736

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Synthesis of some 1-methyl-3-alkoxy-5-arylpyrrolecarboxylic acids and derivatives

Autor: G. M. Shutske, E. Campaigne

Publikováno v: Journal of Heterocyclic Chemistry. 12:67-74

By a combination of hydrolysis, decarboxylation, and methylation diethyl 1-methyl-3-hydroxy-5-phenylpyrrole-2,4-dicarboxylate was converted into 1-methyl-3-methoxy-5-phenyl-pyrrole-2,4-dicarboxylic acid (5) and into the isomeric compounds ethyl 1-met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f826dffa48f6103f7a86773c7e4396e9
https://doi.org/10.1002/jhet.5570120111

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The preparation and aqueous basic oxidation of diethyl 1-methyl-3-hydroxy-5-phenylpyrrole-2,4-dicarboxylate

Autor: E. Campaigne, G. M. Shutske

Publikováno v: Journal of Heterocyclic Chemistry. 11:929-936

Diethyl 1-methyl-3-hydroxy-5-phenylpyrrole-2,4-dicarboxylate has been synthesized in good yield from readily available materials, diethyl benzylidenemalonate and ethyl sarcosinate. It was found to react with oxygen in aqueous base to give two oxidati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df5e99ace943e163268df0bcbd02d0d6
https://doi.org/10.1002/jhet.5570110614

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Synthesis of some 5-aryl-2,2′-dipyrromethenes as analogs of prodigiosin

Autor: E. Campaigne, G. M. Shutske

Publikováno v: Journal of Heterocyclic Chemistry. 13:497-503

Three new dipyrromethenes have been synthesized as analogs of prodigiosin: 3-methoxy-5-phenyl-2,2′-dipyrromethene (10a), 3-methoxy-4 -pentyl-5-phenyl-5′-methyl-2,2′-dipyrromethene (10b), and 3-methoxy-4′-pentyl-5′-methyl-5-(2″-thienyl)-2,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ae2bb8ecfe9eb5cb42e8d1f83cc5604
https://doi.org/10.1002/jhet.5570130315

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Synthesis of some 3-Hydroxy-5-pyridylpyrrole derivatives

Autor: John C. Payne, G. M. Shutske, E. Campaigne

Publikováno v: Journal of Heterocyclic Chemistry. 14:329-331

Ethyl sarcosinate adds to 2, −3- and 4-pyridylmethylidenemalonates to produce the Michael adducts, which can be conveniently cyclized to oxopyrrolidine diesters under Dieckmann conditions. Mild oxidation converted the crude adducts to the isomeric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03b5815dd61d219aae8900b0f6110890
https://doi.org/10.1002/jhet.5570140235

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The reduction of l-methyl-3-methoxy-5-arylpyrrole-2- and -4-carboxylic esters with selected reducing agents

Autor: G. M. Shutske, E. Campaigne

Publikováno v: Journal of Heterocyclic Chemistry. 12:317-319

Three new rnethoxypyrrole esters, ethyl 1-methyl-3-methoxy-5-phenylpyrrole-2-earboxylate, diethyl l-methyl-3-methoxy-5-phenylpyrrole-2,4-diearboxylate, and ethyl l-methyl-2-phenyl-4-methoxypyrrole-3-carboxylate were reduced with diborane/tetrahydrofu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce53c067864e7107bb752234d4dfd4d2
https://doi.org/10.1002/jhet.5570120221

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