Zobrazeno 1 - 10
of 120
pro vyhledávání: '"G M, Shutske"'
Autor:
J. D. Iv Tomer, G. M. Shutske
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 29
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 18(5)
Tacrine (THA) is a potent cholinesterase inhibitor being studied for the treatment of Alzheimer's disease. The metabolism and excretion of THA were studied in rats following a single oral dose of 20 mg/kg of THA. The results show THA was extensively
Autor:
G. M. Shutske, E. Campaigne
Publikováno v:
Journal of Heterocyclic Chemistry. 12:67-74
By a combination of hydrolysis, decarboxylation, and methylation diethyl 1-methyl-3-hydroxy-5-phenylpyrrole-2,4-dicarboxylate was converted into 1-methyl-3-methoxy-5-phenyl-pyrrole-2,4-dicarboxylic acid (5) and into the isomeric compounds ethyl 1-met
Autor:
E. Campaigne, G. M. Shutske
Publikováno v:
Journal of Heterocyclic Chemistry. 11:929-936
Diethyl 1-methyl-3-hydroxy-5-phenylpyrrole-2,4-dicarboxylate has been synthesized in good yield from readily available materials, diethyl benzylidenemalonate and ethyl sarcosinate. It was found to react with oxygen in aqueous base to give two oxidati
Autor:
E. Campaigne, G. M. Shutske
Publikováno v:
Journal of Heterocyclic Chemistry. 13:497-503
Three new dipyrromethenes have been synthesized as analogs of prodigiosin: 3-methoxy-5-phenyl-2,2′-dipyrromethene (10a), 3-methoxy-4 -pentyl-5-phenyl-5′-methyl-2,2′-dipyrromethene (10b), and 3-methoxy-4′-pentyl-5′-methyl-5-(2″-thienyl)-2,
Autor:
Escorihuela, Jorge1 (AUTHOR) jorge.escorihuela@uv.es, Fustero, Santos1 (AUTHOR) santos.fustero@uv.es
Publikováno v:
Chemical Record. Sep2023, Vol. 23 Issue 9, p1-25. 25p.
Autor:
Jung, Min‐Jung1 (AUTHOR), Paladhi, Sushovan1,2 (AUTHOR), Song, Choong Eui1 (AUTHOR) s1673@skku.edu
Publikováno v:
Bulletin of the Korean Chemical Society. May2023, Vol. 44 Issue 5, p420-424. 5p.
Publikováno v:
Journal of Heterocyclic Chemistry. 14:329-331
Ethyl sarcosinate adds to 2, −3- and 4-pyridylmethylidenemalonates to produce the Michael adducts, which can be conveniently cyclized to oxopyrrolidine diesters under Dieckmann conditions. Mild oxidation converted the crude adducts to the isomeric
Autor:
G. M. Shutske, E. Campaigne
Publikováno v:
Journal of Heterocyclic Chemistry. 12:317-319
Three new rnethoxypyrrole esters, ethyl 1-methyl-3-methoxy-5-phenylpyrrole-2-earboxylate, diethyl l-methyl-3-methoxy-5-phenylpyrrole-2,4-diearboxylate, and ethyl l-methyl-2-phenyl-4-methoxypyrrole-3-carboxylate were reduced with diborane/tetrahydrofu