Výsledky vyhledávání - "G M, Proshkina"

Specific Cytotoxicity of Targeted 177Lu and 212Pb-Based Radiopharmaceuticals

Autor: G. M. Proshkina, S. M. Deev, P V Shegai, Konstantin Kokov, A D Kaprin, B V Egorova, Anna D. Plyutinskaya, A. A. Pankratov, V. A. Golovachenko, M S Vorontsova, E N Lebedenko, E. R. Nemtsova, D. Yu. Chuvilin, A. A. Shulga

Publikováno v: Bulletin of Experimental Biology and Medicine. 171:627-632

Two radiopharmaceutical preparations were developed on the basis of artificial targeted polypeptide ZHER2 specific to HER2/neu tumor marker and radionuclides 177Lu (ZHER2-HSA-chelator-177Lu) or 212Pb (ZHER2-HSA-chelator-212Pb). The objective was to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b956afdc2d0b483ff906be90f549d47
https://doi.org/10.1007/s10517-021-05283-4

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Comparative Evaluation of Engineered Polypeptide Scaffolds in HER2-Targeting Magnetic Nanocarrier Delivery

Autor: Sergey M. Deyev, Victoria O. Shipunova, Anton A. Popov, Vladislav D Soloviev, G. M. Proshkina, Polina A. Kotelnikova, Olga A Kolesnikova, Maxim P. Nikitin

Publikováno v: ACS Omega
ACS Omega, Vol 6, Iss 24, Pp 16000-16008 (2021)

Targeted drug delivery is one of the most intriguing and challenging issues in modern biomedicine. For active targeting, full-size IgG molecules (150 kDa) are usually used. Recent studies have revealed that small artificial polypeptide scaffolds such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a4425f92f10aeb3ac4162042a62792
http://europepmc.org/articles/PMC8223436

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Delivery of Barnase to Cells in Liposomes Functionalized by Her2-Specific DARPin Module

Autor: E. I. Shramova, M. V. Shilova, G. M. Proshkina, Victoria O. Shipunova, Alexey A. Schulga, S. M. Deyev

Publikováno v: Russian Journal of Bioorganic Chemistry. 46:1156-1161

In this work for the first time we demonstrate the possibility of ribonuclease barnase delivery to HER2-positive human cancer cells in a liposomal form. The principle of loading liposomes with ribonuclease is based on the electrostatic interaction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50adaa638ba0b6cf61e0166c6972e0fc
https://doi.org/10.1134/s1068162020060308

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Near-infrared activated cyanine dyes as agents for photothermal therapy and diagnosis of tumors

Autor: E. I. Shramova, G. M. Proshkina, Aleksander B. Kotlyar, Sergey M. Deyev, E. N. Lebedenko

Publikováno v: Acta Naturae

Today, it has become apparent that innovative treatment methods, including those involving simultaneous diagnosis and therapy, are particularly in demand in modern cancer medicine. The development of nanomedicine offers new ways of increasing the the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5bc4dd3955c395b6e71ec3b2ff3ef70
https://doi.org/10.32607/actanaturae.11028

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In vitro and in vivo Evaluation of the Radiochemical Compound Based on 99mTechnetium Labelled DARPin 9_29 for Molecular Visualization of Malignancies Overexpressing Her2/neu

Autor: Anzhelika Vorobyeva, A. Medvedeva, A. Shulga, V. Chernov, G. M. Proshkina, M. S. Lar’kina, R. Zel'chan, Vladimir M. Tolmachev, O. Bragina, Anna Orlova, Sergey M. Deyev

Publikováno v: Medical Radiology and radiation safety. 65:37-41

Purpose: Evaluation of a radiopharmaceutical based on 99mTc-labeled targeted molecules DARPin9_29 for radionuclide diagnostics of malignancies with Her2/neu overexpression. Material and methods: The DARPin9_29 sequence was amplified from the plasmid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::933542dc001a4c999559f41ac76cf62c
https://doi.org/10.12737/1024-6177-2020-65-1-37-41

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Polymer/magnetite carriers functionalized by HER2-DARPin: Avoiding lysosomes during internalization and controlled toxicity of doxorubicin by focused ultrasound induced release

Autor: M V, Novoselova, E I, Shramova, O V, Sergeeva, E Y, Shcherbinina, S V, Perevoschikov, P, Melnikov, O Yu, Griaznova, I S, Sergeev, E V, Konovalova, A A, Schulga, G M, Proshkina, T S, Zatsepin, S M, Deyev, D A, Gorin

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine. 47:102612

Nanomedicine has revolutionized the available treatment options during the last decade, but poor selectivity of targeted drug delivery and release is still poses a challenge. In this study, doxorubicin (DOX) and magnetite nanoparticles were encapsula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78c1c122b3aeb3e7c575c3dfa58aabe
https://doi.org/10.1016/j.nano.2022.102612

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Barnase*Barstar-guided two-step targeting approach for drug delivery to tumor cells in vivo

Autor: Georgij B Telegin, E. I. Shramova, N.A. Zolotova, G. M. Proshkina, D.S. Dzhalilova, M. V. Shilova, Sergey M. Deyev, Anastasiya V. Ryabova

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 340

For precise ligation of a targeting and cytotoxic moiety, the use of Barnase-Barstar pair as a molecular glue is proposed for the first time. Targeting was mediated through the use of a scaffold protein DARPin_9–29 specific for the human epidermal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2841ffe210f99197aeedadf879835b
https://pubmed.ncbi.nlm.nih.gov/34740723

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Natural and Designed Toxins for Precise Therapy: Modern Approaches in Experimental Oncology

Autor: E. I. Shramova, G. M. Proshkina, Olga A. Shilova, Sergey Deyev

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 4975, p 4975 (2021)

Cancer cells frequently overexpress specific surface receptors providing tumor growth and survival which can be used for precise therapy. Targeting cancer cell receptors with protein toxins is an attractive approach widely used in contemporary experi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308c8d640ac2b73847f34be16cedfcff
http://europepmc.org/articles/PMC8124712

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Specific Cytotoxicity of Targeted

Autor: A A, Pankratov, E R, Nemtsova, A D, Plyutinskaya, M S, Vorontsova, D Yu, Chuvilin, B V, Egorova, K V, Kokov, S M, Deev, E N, Lebedenko, G M, Proshkina, A A, Shul'ga, V A, Golovachenko, P V, Shegai, A D, Kaprin

Publikováno v: Bulletin of experimental biology and medicine. 171(5)

Two radiopharmaceutical preparations were developed on the basis of artificial targeted polypeptide ZHER2 specific to HER2/neu tumor marker and radionuclides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1b2cbe647842056ca49b878260f30f8
https://pubmed.ncbi.nlm.nih.gov/34626281

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Dual Regioselective Targeting the Same Receptor in Nanoparticle-Mediated Combination Immuno/Chemotherapy for Enhanced Image-Guided Cancer Treatment

Autor: Andrei V. Kabashin, G. M. Proshkina, Sergey M. Deyev, Victoria O. Shipunova, Alexey A. Schulga, E. I. Shramova, Ivan V. Zelepukin, Paras N. Prasad, Elena N. Komedchikova, Georgij B Telegin, Polina A. Kotelnikova, Hilliard L. Kutscher

Publikováno v: ACS Nano
ACS Nano, American Chemical Society, 2020, 14 (10), pp.12781-12795. ⟨10.1021/acsnano.0c03421⟩
ACS Nano, 2020, 14 (10), pp.12781-12795. ⟨10.1021/acsnano.0c03421⟩

When combined with immunotherapy, image-guided targeted delivery of chemotherapeutic agents is a promising direction for combination cancer theranostics, but this approach has so far produced only limited success due to a lack of molecular targets on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddce00ba8f18cf0d1a91f40794342a49
https://hal.archives-ouvertes.fr/hal-03097623

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