Zobrazeno 1 - 7
of 7
pro vyhledávání: '"G M, Olins"'
Autor:
G M, Olins, V M, Corpus, S T, Chen, E G, McMahon, M A, Palomo, D E, McGraw, G J, Smits, C L, Null, M A, Brown, S E, Bittner
Publikováno v:
Journal of cardiovascular pharmacology. 22(4)
We describe the pharmacologic properties of SC-52458, 5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(1H-tetrazol - 5-ylphenyl)]pyridine, a novel nonpeptide angiotensin II (AII) receptor antagonist. SC-52458 was a potent inhibitor of [125I]AII bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78e2c546208b61b640c1a4c508ef0293
https://pubmed.ncbi.nlm.nih.gov/7505365
https://pubmed.ncbi.nlm.nih.gov/7505365
Autor:
J R Schuh, Angelo J. Trapani, E G McMahon, J P Koepke, D. B. Reitz, P R Bovy, K S Salles, G M Olins, Edward H. Blaine
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 15(6 Pt 2)
Nonpeptidic imidazole derivatives were recently reported to be angiotensin II receptor antagonists with acute blood pressure-lowering activity. In the present study, we characterized the angiotensin II receptor antagonist properties of one such deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d89ae0801873fe4efc0144dd403586e
https://pubmed.ncbi.nlm.nih.gov/2190928
https://pubmed.ncbi.nlm.nih.gov/2190928
Autor:
P R, Bovy, J M, O'Neal, G M, Olins, D R, Patton, P P, Mehta, E G, McMahon, M, Palomo, J, Schuh, D, Blehm
Publikováno v:
The Journal of biological chemistry. 264(34)
A linear decapeptide, [cyclohexylalanine 106]ANP-(105-114)NH2 (1), where ANP is atrial natriuretic peptide, was prepared by solid phase synthesis and purified by reverse-phase liquid chromatography. This novel peptide was found to bind to ANP recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17008b5ea5336e23008904363d6d8fc2
https://pubmed.ncbi.nlm.nih.gov/2555353
https://pubmed.ncbi.nlm.nih.gov/2555353
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 249(2)
The in vivo metabolism of atrial natriuretic peptide (ANP) has been studied in the rat after i.v. administration of either [106Phe-14C]- or [126Tyr-125I]-ANP(103-126). Plasma samples containing radioactive peptides were separated by reverse-phase hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9ea908fc45c6a45a0031ffaf87ac92d
https://pubmed.ncbi.nlm.nih.gov/2524586
https://pubmed.ncbi.nlm.nih.gov/2524586
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 249(1)
We examined the interaction of SC-46542 [des(Phe106, Gly107, Ala115, Gln116)-AP(103-126)], a non-guanylate cyclase-linked atriopeptin (AP) binding site ligand, with thiorphan, an inhibitor of endopeptidase 24.11, on mean arterial pressure, urine flow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47ef660ef434ce118e052d65aa47d66a
https://pubmed.ncbi.nlm.nih.gov/2565386
https://pubmed.ncbi.nlm.nih.gov/2565386
Publikováno v:
The Journal of biological chemistry. 263(22)
Atrial natriuretic peptide (ANP) contains a disulfide which is generally considered to be required for biological activity. A truncated linear ANP analog, des-Cys105,Cys121-ANP-(104-126) (referred to as analog I), that lacks the 2 cysteine residues o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87d42ff92dc1a0baaa20c65775cd7cd0
https://pubmed.ncbi.nlm.nih.gov/2899082
https://pubmed.ncbi.nlm.nih.gov/2899082
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 251(3)
We examined the effects of an acute infusion of MB 22,948 (2-o-propoxyphenyl-8-azapurin-6-one), a (cGMP)-selective phosphodiesterase inhibitor, on mean arterial pressure (MAP) and urinary sodium excretion in anesthetized rats. MB 22,948 (at doses of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e32bc964cef784718652ecb721d9544
https://pubmed.ncbi.nlm.nih.gov/2557409
https://pubmed.ncbi.nlm.nih.gov/2557409