Applying Mendelian randomization to appraise causality in relationships between smoking, depression and inflammation

Autor: D. Galan, B. I. Perry, V. Warrier, C. C. Davidson, O. Stupart, D. Easton, G. M. Khandaker, G. K. Murray

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Smoking, inflammation and depression commonly co-occur and may be mechanistically linked. However, key questions remain around the direction of association and the influence of residual confounding. We aimed to characterize the association b

Externí odkaz: https://doaj.org/article/654f22419192475e9d21a7a6c5bf3b0a

Childhood Immuno-metabolic Markers and Risk of Depression and Psychosis in Adulthood: A Prospective Birth Cohort Study

Autor: N A, Donnelly, B I, Perry, H J, Jones, G M, Khandaker

Publikováno v: Donnelly, N, Perry, B, Jones, H J & Khandaker, G 2022, ' Childhood Immuno-metabolic Markers and Risk of Depression and Psychosis in Adulthood: A Prospective Birth Cohort Study ', Psychoneuroendocrinology, vol. 139, 105707 . https://doi.org/10.1016/j.psyneuen.2022.105707

BackgroundMetabolic and inflammatory disorders commonly co-occur with depression and psychosis, with emerging evidence implicating immuno-metabolic dysfunction in their aetiology. Previous studies have reported metabolic dysfunction and inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302d203207114ae53849f27ac4fd5dc3
https://research-information.bris.ac.uk/en/publications/581bed56-c6b2-41ab-8306-0b8c7ec982a0

Identifying key targets for interventions to improve psychological wellbeing: replicable results from four UK cohorts

Autor: J, Stochl, E, Soneson, A P, Wagner, G M, Khandaker, I, Goodyer, P B, Jones

Publikováno v: Psychological Medicine

Background An increasing importance is being placed on mental health and wellbeing at individual and population levels. While there are several interventions that have been proposed to improve wellbeing, more evidence is needed to understand which as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20317092e7a62fa1b9b3f78025c8fbe9
https://pubmed.ncbi.nlm.nih.gov/30430959

P.3.04 Deciphering polygenic risk for inflammation and depressive symptoms: A two-sample network analysis approach

Autor: Johannes Kopf-Beck, Nils Kappelmann, Martin E. Keck, G. M. Khandaker

Publikováno v: European Neuropsychopharmacology. 29:S680-S681

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75b37a2f6ef81fa6225ef227d458a8e1
https://doi.org/10.1016/j.euroneuro.2019.01.066

Clinical and sociodemographic comparison of people at high-risk for psychosis and with first-episode psychosis

Autor: J, Zimbrón, S, Ruiz de Azúa, G M, Khandaker, P K, Gandamaneni, C M, Crane, A, González-Pinto, J, Stochl, P B, Jones, J, Pérez

Publikováno v: Acta psychiatrica Scandinavica. 127(3)

To compare clinical and sociodemographic characteristics previously associated with psychosis, between individuals at high-risk for psychosis (HR) and patients experiencing a first episode psychosis (FEP), to achieve a better understanding of factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::223571c9d45796907a5293564bd53e63
https://pubmed.ncbi.nlm.nih.gov/22906094