Výsledky vyhledávání - "G M, Castillo"

Laminin inhibition of beta-amyloid protein (Abeta) fibrillogenesis and identification of an Abeta binding site localized to the globular domain repeats on the laminin a chain

Autor: G M, Castillo, W, Lukito, E, Peskind, M, Raskind, D A, Kirschner, A G, Yee, A D, Snow

Publikováno v: Journal of neuroscience research. 62(3)

beta-Amyloid protein (Abeta) is a major component of neuritic plaques and cerebrovascular amyloid deposits in the brains of patients with Alzheimer's disease (AD). Inhibitors of Abeta fibrillogenesis are currently sought as potential future therapeut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6ec05ece3593243c066e923ed0cb836
https://pubmed.ncbi.nlm.nih.gov/11054814

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Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation

Autor: John Bondo Hansen, Wenhua Yang, G. M. Castillo, A. D. Snow, Malcolm J. Sheardown, J. A. Cummings, Martin Edward Judge, Karin Rimvall

Publikováno v: Diabetes. 47(4)

Islet amyloidosis is characterized by the deposition and accumulation of amylin in pancreatic beta-cells and is observed in 90% of patients with type 2 diabetes. Previous studies have also revealed the presence of the specific heparan sulfate proteog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a28e3710a55f8467ab031c8a4cba86
https://pubmed.ncbi.nlm.nih.gov/9568695

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Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability

Autor: G M, Castillo, C, Ngo, J, Cummings, T N, Wight, A D, Snow

Publikováno v: Journal of neurochemistry. 69(6)

Perlecan is a specific heparan sulfate proteoglycan that accumulates in the fibrillar beta-amyloid (A beta) deposits of Alzheimer's disease. Perlecan purified from the Engelbreth-Holm-Swarm tumor was used to define perlecan's interactions with A beta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed0935553664c3b4ea10706899e932fb
https://pubmed.ncbi.nlm.nih.gov/9375678

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Localization of perlecan (or a perlecan-related macromolecule) to isolated microglia in vitro and to microglia/macrophages following infusion of beta-amyloid protein into rodent hippocampus

Autor: J D, Miller, J, Cummings, G A, Maresh, D G, Walker, G M, Castillo, C, Ngo, K, Kimata, M G, Kinsella, T N, Wight, A D, Snow

Publikováno v: Glia. 21(2)

The origin of the heparan sulfate proteoglycan (PG), perlecan, in beta-amyloid protein (A beta)-containing amyloid deposits in Alzheimer's disease (AD) brain is not known. In the present investigation we used indirect immunofluorescence, SDS-PAGE, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::854a68b1d4a04e19b7e195125d069217
https://pubmed.ncbi.nlm.nih.gov/9336237

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