Výsledky vyhledávání - "G M, Carrera"

Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR

Autor: E. Gubbins, D. W. Morgan, Edward T. Olejniczak, Jean M. Severin, S. K. Davidsen, G. Sheppard, G. M. Carrera, Robert L. Simmer, D. H. Steinman, David G. Nettesheim, R. P. Meadows, T. F. Holzman, and J. B. Summers, H. Smith, P. A. Marcotte, Suzanne B. Shuker, Philip J. Hajduk, Karl A. Walter, Stephen W. Fesik

Publikováno v: Journal of the American Chemical Society. 119:5818-5827

With the use of an NMR-based method, potent (IC50 < 25 nM) nonpeptide inhibitors of the matrix metalloproteinase stromelysin (MMP-3) were discovered. The method, called SAR by NMR (for structure−activity relationships by nuclear magnetic resonance)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08e458e8b044870f08d7fbd35c1a163e
https://doi.org/10.1021/ja9702778

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Synthesis and in vitro characterization of novel amino terminally modified oxotremorine derivatives for brain muscarinic receptors

Autor: D S, Garvey, J T, Wasicak, J Y, Chung, Y K, Shue, G M, Carrera, P D, May, M M, McKinney, D, Anderson, E, Cadman, L, Vella-Rountree

Publikováno v: Journal of Medicinal Chemistry. 35:1550-1557

A series of novel 2-substituted acetylenic pyrrolidines and piperidines related to oxotremorine (1) were prepared and evaluated in vitro as muscarinic cholinergic agents at brain M1 and M2 receptors. One analogue, 3-(2-oxo-1-pyrrolidinyl)-1-[2(R)-pyr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa619542c4ac99cd95a8adbdada490c
https://doi.org/10.1021/jm00087a008

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Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists

Publikováno v: Journal of medicinal chemistry. 41(1)

Studies conducted with the goal of discovering a second-generation platelet-activating factor (PAF) antagonist have identified a novel class of potent and orally active antagonists which have high aqueous solubility and long duration of action in ani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3bb2c074df0fa0c2bbeaf883649b3410
https://pubmed.ncbi.nlm.nih.gov/9438024

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Hepatomegaly in Human and Experimental Amebic Colitis *

Autor: G. M. Carrera, E. H. Sadun

Publikováno v: The American Journal of Tropical Medicine and Hygiene. 1:962-965

Summary The average weight of the liver relative to body weight in 7 subjects who died with active amebic colitis and without evident concomitant hepatic disease was slightly higher than that of normal subjects of equivalent age. Similarly the averag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193de11d390567eedb084d4697e82a2a
https://doi.org/10.4269/ajtmh.1952.1.962

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CHRONIC EOSINOPHILIA DUE TO VISCERAL LARVA MIGRANS

Autor: G. M. Carrera, Paul C. Beaver, C. H. Snyder, J. W. Lafferty, J. H. Dent

Publikováno v: Pediatrics. 9:7-19

Three cases of chronic extreme eosinophilia with granulomatous lesions in the liver have been studied. A larval nematode observed in sections from the liver of one patient has been identified either as Toxocara canis or Toxocara cati, common cosmopol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::836bc9e25dce9d5bcdfc2166edc6d3e2
https://doi.org/10.1542/peds.9.1.7

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Human sparganosis in Louisiana: a case report

Autor: N H, Fischman, J B, Blalock, G M, Carrera

Publikováno v: The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society. 129(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f4bedc7ebfc5143f59ee5f6dbc11aed
https://pubmed.ncbi.nlm.nih.gov/908865

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The rat liver asialoglycoprotein receptor polypeptide must be inserted into a microsome to achieve its active conformation

Autor: E C, Hsueh, E C, Holland, G M, Carrera, K, Drickamer

Publikováno v: The Journal of biological chemistry. 261(11)

Affinity chromatography on galactose-Sepharose has been utilized to demonstrate that rat liver asialoglycoprotein receptor synthesized in vitro in a reticulocyte lysate system is capable of binding carbohydrate ligand only when dog pancreas microsome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c663266b40be03bdefa134ff370281e
https://pubmed.ncbi.nlm.nih.gov/3082873

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