Výsledky vyhledávání

Randomized, double-blind, placebo-controlled, multicentered trial of the efficacy of a single dose of live oral cholera vaccine CVD 103-HgR in preventing cholera following challenge with Vibrio cholerae O1 El tor inaba three months after vaccination

Autor: C O, Tacket, M B, Cohen, S S, Wasserman, G, Losonsky, S, Livio, K, Kotloff, R, Edelman, J B, Kaper, S J, Cryz, R A, Giannella, G, Schiff, M M, Levine

Publikováno v: Infection and immunity. 67(12)

CVD 103-HgR is a live oral cholera vaccine strain constructed by deleting 94% of the gene for the enzymatically active A subunit of cholera toxin from classical Inaba Vibrio cholerae O1 569B; the strain also contains a mercury resistance gene as an i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53062d5f81a546d5cf2cd9f89c5344df
https://pubmed.ncbi.nlm.nih.gov/10569747

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Safety and immunogenicity of live oral cholera vaccine candidate CVD 110, a delta ctxA delta zot delta ace derivative of El Tor Ogawa Vibrio cholerae

Autor: C O, Tacket, G, Losonsky, J P, Nataro, S J, Cryz, R, Edelman, A, Fasano, J, Michalski, J B, Kaper, M M, Levine

Publikováno v: The Journal of infectious diseases. 168(6)

The current pandemic of cholera is caused primarily by Vibrio cholerae O1 of the El Tor biotype. Live attenuated classical biotype V. cholerae vaccine strains prevent severe and moderate cholera due to either biotype in challenged volunteers but may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbe6d0b2ab95bec18babfb30336b6200
https://pubmed.ncbi.nlm.nih.gov/8245542

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Safety, immunogenicity, and excretion pattern of single-dose live oral cholera vaccine CVD 103-HgR in Peruvian adults of high and low socioeconomic levels

Autor: J B Kaper, Carlos Seas, B Butron, Claudio F. Lanata, Eduardo Gotuzzo, E Salazar, Mary E. Penny, Rosa Ruiz, G Losonsky, S S Wasserman

Groups of 122 Peruvian adults of low socioeconomic level (SEL) and 125 of high SEL received a randomly allocated 5 x 10(9)- or 5 x 10(8)-CFU dose of CVD 103-HgR live oral cholera vaccine or a placebo. The vaccine was well tolerated. Vibriocidal seroc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec54a5aaefdb0db862c2a7743a05078
https://europepmc.org/articles/PMC281106/

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Onset and duration of protective immunity in challenged volunteers after vaccination with live oral cholera vaccine CVD 103-HgR

Autor: C O, Tacket, G, Losonsky, J P, Nataro, S J, Cryz, R, Edelman, J B, Kaper, M M, Levine

Publikováno v: The Journal of infectious diseases. 166(4)

CVD 103-HgR is a live oral cholera vaccine that, in phase I and II studies to date, has been well tolerated and immunogenic. In challenge studies of US volunteers conducted 4-5 weeks after vaccination, CVD 103-HgR provided significant protection agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7fcc2909c272cf33816e263a30aca8e4
https://pubmed.ncbi.nlm.nih.gov/1527420

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Hydraulic Fracturing to Increase Fluid Flow

Autor: I. Klich, L. C. Murdoch, G. Losonsky, P. Cluxton

Publikováno v: Contaminated Soil ’90 ISBN: 9789401054430

Hydraulic fracturing is a method of creating permeable layers to increase fluid flow in low permeability formations, and it should improve the performance of several in situ methods of remediation. We have shown that hydraulic fractures can be create

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a86275ae89d11427f70dbc751c335ea
https://doi.org/10.1007/978-94-011-3270-1_241

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Preliminary assessment of the safety and immunogenicity of live oral cholera vaccine strain CVD 103-HgR in healthy Thai adults

Autor: Benjaluck Prayurahong, U. Vongsthongsri, Varunee Desakorn, Wichai Supanaranond, S. Migasena, Punnee Pitisuttitham, G Losonsky, Pravan Suntharasamai, B Tall, J Ketley

Publikováno v: Infection and immunity. 57(11)

A single dose (5 x 10(8) organisms) of attenuated A- B+ Vibrio cholerae classical Inaba recombinant vaccine strain CVD 103-HgR or placebo was administered to 24 healthy young Thai adults in a randomized, placebo-controlled, double-blind trial of safe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3545fd266088ddddb5ead2a02787eacd
https://pubmed.ncbi.nlm.nih.gov/2807523

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The current status of cholera vaccine development and experience with cholera vaccine trials in volunteers

Autor: M M, Levine, J B, Kaper, D, Herrington, G, Losonsky, C, Tacket, B, Tall

Publikováno v: The Southeast Asian journal of tropical medicine and public health. 19(3)

In recent years notable advances have been made in the development of improved vaccines to prevent cholera. These new vaccines are administered orally to maximally stimulate intestinal secretory immunity. Killed vibrios, given in conjunction with pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03c87dc40ccaff34374a35b809d891fc
https://pubmed.ncbi.nlm.nih.gov/3217822

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