Zobrazeno 1 - 10
of 210
pro vyhledávání: '"G Le Baut"'
Autor:
Mathurin Fumery, G Le Baut, A Lahaye, Pauline Wils, Stephanie Viennot, Nicolas Duveau, Maria Nachury, C Perignon, Clara Yzet, C Roussillon, Julien Loreau, Benjamin Pariente, G Lepeut
Publikováno v:
Journal of Crohn's and Colitis. 13:S262-S263
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8efe27f089ff2382689d8ddb8217f0cf
https://doi.org/10.1093/ecco-jcc/jjy222.447
https://doi.org/10.1093/ecco-jcc/jjy222.447
Publikováno v:
Parasite, Vol 9, Iss 4, Pp 367-370 (2002)
Leishmania mexicana promastigote and intracellular amastigote growths were inhibited by the water-soluble furan-2-carboxamide issued from the pharmacophore 2-amino-4,6-dimethylpyridine with IC50 values of 69 +/- 2 and 89 +/- 9 microM, respectively. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2bf2dca33e8cf48cd5d770cac57a34
https://doaj.org/article/1f832ba8c06942a69cb8a826c6256a84
https://doaj.org/article/1f832ba8c06942a69cb8a826c6256a84
Autor:
J. M. Robert, G. Le Baut, François Lang, Christine Bobin-Dubigeon, J. Y. Petit, S. Robert, Xavier Collin, N. Grimaud
Publikováno v:
Pharmacy and Pharmacology Communications. 5:233-238
A series of N-pyridinyl(methyl)fluorobenzamides issued from 2,4-dimethyl-6-aminopyridine and 3-aminomethylpyridine were synthesized and evaluated as inhibitors of TNF-α production. Although less active than the corresponding phthalimides, several pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2ee69fcec13a44436d0ae1538804923
https://doi.org/10.1211/146080899128734659
https://doi.org/10.1211/146080899128734659
Autor:
G. Le Baut, Szelenyi I, J. Schmidt, M. Duflos, B. Kutscher, U. Achterrath, Fabienne Fouchard, Cecilia Menciu, B. Nickel, Eckhard Dr. Günther, P. Emig
Publikováno v:
Journal of Medicinal Chemistry. 42:638-648
A series of new N-(pyridin-4-yl)-(indol-3-yl)alkylamides 44-84 has been prepared in the search of novel antiallergic compounds. Synthesis of the desired ethyl (2-methyindol-3-yl)acetates 1-4 was achieved by indolization under Fischer conditions; Japp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5cc350c7fc413dd09155dec483b2a9
https://doi.org/10.1021/jm981079+
https://doi.org/10.1021/jm981079+
Autor:
J. Y. Petit, L. Welin, G. Le Baut, Jacqueline Courant, N. Grimaud, Sylvie Robert-Piessard, François Lang, J. M. Robert, B. Robert
Publikováno v:
European Journal of Medicinal Chemistry. 30:915-924
Summary Pharmacomodulation of the non-carboxylic NSAID N -(4,6-dimethylpyridin-2-yl)benzamide 1 led to the synthesis of structurally related furan, thiophene and pyrrole carboxamides 3–14 . The derivatives benzenethiocarboxamides 15–18 and hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad5eb1d3260b21e762b15a94b0c7701c
https://doi.org/10.1016/0223-5234(96)88310-3
https://doi.org/10.1016/0223-5234(96)88310-3
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 50:957-960
The title compound, C 22 H 27 NO 3 , belongs to a class of compounds which are potent inhibitors of lipid peroxidation. Furthermore, it is very effective at inhibiting leukotrienes biosynthesis. The benzenic rings are planar or approximately planar a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4969fae5a05f8a1111e3574c1f3b125f
https://doi.org/10.1107/s0108270193012107
https://doi.org/10.1107/s0108270193012107
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 50:960-963
Both compounds [N-phenyl-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxamide (N-phenyltroloxamide), C 20 H 23 NO 3 , and N-phenyl-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carbothioxamide (N-phenyltroloxthioamide), C 20 H 23 NO 2 S] hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcb76aacb5d9ff8679f96d59dc34f6a3
https://doi.org/10.1107/s0108270193010352
https://doi.org/10.1107/s0108270193010352
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 50:810-813
The entire molecule of 5,7-dimethyl-2-phenyl-3-thioxo-3H-[1,4,2]diazaphospholo[1,5-a]pyridinium-3thiolate, C 14 H 13 N 2 PS 2 , with the exception of the two S atoms, is approximately planar. The π electrons of the N(7)-C(8) bond are partially conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b5c7f298e8bc057254be9613ac02d9c
https://doi.org/10.1107/s0108270193010327
https://doi.org/10.1107/s0108270193010327
Autor:
B. Robert, Sylvie Robert-Piessard, G. Le Baut, M Andriamanamihaja, F Mainard, M. Duflos, J. M. Robert
Publikováno v:
European Journal of Medicinal Chemistry. 29:883-888
A series of borodipeptide derivatives 7–9 , which contain a 6-amino-2,4-dimethylpyridine moiety, was prepared in 3 steps. They were evaluated as hypolipidemic agents in rodents at 20 mg/kg per day. The methioninamide and phenylalaninamide derivativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09633513f1bf850aaa943a8ecf09038b
https://doi.org/10.1016/0223-5234(94)90111-2
https://doi.org/10.1016/0223-5234(94)90111-2
Non-acidic antiinflammatory compounds II. Synthesis and activity of 6-amino-2,4-lutidine derivatives
Autor:
J. M. Robert, L. Welin, J. Y. Petit, G. Le Baut, Sylvie Robert-Piessard, E. N. Khettab, M. Duflos, N. Grimaud
Publikováno v:
European Journal of Medicinal Chemistry. 29:841-854
Benzamides I, phenylalkanamides II and cinnamamides III are structurally related to the antiinflammatory N-(4,6-dimethylpyridin-2-yl)benzamide I. These were synthesized and the transformation of the 2-aminopyridine nucleus of benzamides I into a 2-im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2ec6f57805a93b730bd526821dba9f9
https://doi.org/10.1016/0223-5234(94)90107-4
https://doi.org/10.1016/0223-5234(94)90107-4