Zobrazeno 1 - 10 of 55 pro vyhledávání: '"G L, Stiles"'
1
Functional consequences of A1 adenosine-receptor phosphorylation by the β-adrenergic receptor kinase
Autor: V, Ramkumar, M, Kwatra, J L, Benovic, G L, Stiles, G L, Stilesa
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1179:89-97
Treatment of smooth-muscle cells with R -phenylisopropyladenosine ( R -PIA) leads to a loss of A 1 adenosine receptor (A 1 AR)-mediated inhibition of adenylate cyclase, a decrease in receptor number and an increase in receptor phosphorylation. In thi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29def22032eedcb8da1ce7e07789d5d5
https://doi.org/10.1016/0167-4889(93)90075-z
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2
The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells
Autor: M A Beaven, G L Stiles, H Ali, Vickram Ramkumar
Publikováno v: Journal of Biological Chemistry. 268:16887-16890
Mast cells release the mediators of the immediate hypersensitivity reaction. Adenosine is known to modulate this process, but the receptor responsible for this is not the classical A1 or A2 adenosine receptors. This study was undertaken to determine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a7e191f53f43727672d184c07684027
https://doi.org/10.1016/s0021-9258(19)85277-8
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3
Adenosine Receptors
Autor: M E, Olah, G L, Stiles
Publikováno v: Annual Review of Physiology. 54:211-225
Our knowledge of A1 and A2ARs has grown dramatically since they were first defined by Burnstock. With the recent purification of the A1AR and the cDNA cloning of the A2AR, an even more rapid expansion of information regarding their structure, functio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e87d4b1e665d06cdc4edd23051170be
https://doi.org/10.1146/annurev.ph.54.030192.001235
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4
Identification of threonine residues controlling the agonist-dependent phosphorylation and desensitization of the rat A(3) adenosine receptor
Autor: T M, Palmer, G L, Stiles
Publikováno v: Molecular pharmacology. 57(3)
Activation of the A(3) adenosine receptor (A(3)AR) contributes to the cardioprotective, bronchoconstrictive, and hypotensive effects of adenosine. Agonist occupation of the A(3)AR results in a rapid desensitization of receptor function, which is asso
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5524057b557a123a45b4b25d1139ea0
https://pubmed.ncbi.nlm.nih.gov/10692494
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6
Molecular basis for subtype-specific desensitization of inhibitory adenosine receptors. Analysis of a chimeric A1-A3 adenosine receptor
Autor: T M, Palmer, J L, Benovic, G L, Stiles
Publikováno v: The Journal of biological chemistry. 271(25)
The differing effects of short-term agonist exposure on the two inhibitory adenosine receptor (AR) subtypes have been examined using Chinese hamster ovary cells stably expressing the hemagglutinin epitope-tagged human A1AR and rat A3AR. Under conditi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ba2ffe00a2ee3610e9bd4cc6ff7719b
https://pubmed.ncbi.nlm.nih.gov/8663009
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7
Separate promoters in the human A1 adenosine receptor gene direct the synthesis of distinct messenger RNAs that regulate receptor abundance
Autor: H, Ren, G L, Stiles
Publikováno v: Molecular pharmacology. 48(6)
There are two types of transcripts for the human A1, adenosine receptor. They are expressed in a tissue-specific manner in human tissues and contain distinct exons. Previously, it had appeared that the two transcripts may have occurred through altern
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc1567fd1774adfd5925f6e1e4dab39f
https://pubmed.ncbi.nlm.nih.gov/8848013
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8
Adenosine receptors: protein and gene structure
Autor: M E, Olah, H, Ren, G L, Stiles
Publikováno v: Archives internationales de pharmacodynamie et de therapie. 329(1)
Adenosine produces a wide variety of effects throughout the body via activation of cell surface adenosine receptors. Adenosine receptors belong to the family of seven transmembrane domain G protein-coupled receptors and four subtypes have been cloned
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f148558041cd717d166e31ec09c3ad5d
https://pubmed.ncbi.nlm.nih.gov/7639615
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9
Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors
Autor: M E, Olah, K A, Jacobson, G L, Stiles
Publikováno v: The Journal of biological chemistry. 269(40)
Adenosine receptor (AR) agonists and antagonists are approximately 100-fold and 100,000-fold, respectively, more potent at the bovine A1AR as compared to the rat A3AR. To determine regions of ARs involved in ligand recognition, chimeric receptors com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a72980fe7534c0c93de6eb6832876e3
https://pubmed.ncbi.nlm.nih.gov/7929142
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10
Identification of an adenosine receptor domain specifically involved in binding of 5'-substituted adenosine agonists
Autor: M E, Olah, K A, Jacobson, G L, Stiles
Publikováno v: The Journal of biological chemistry. 269(27)
The bovine A1 adenosine receptor (A1AR) and rat A3 adenosine receptor (A3AR) display distinct agonist and antagonist binding properties. To identify regions involved in ligand recognition, A1AR/A3AR chimeric receptors were created, expressed in COS-7
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::60f40b2e2e8588766015493703b7a238
https://pubmed.ncbi.nlm.nih.gov/8027060
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