Zobrazeno 1 - 10
of 179
pro vyhledávání: '"G L, Neil"'
By utilizing new types of producing microorganisms and isolating these on rather unusual growth media, we hope to produce new classes of antitumor drugs. In the detection system, we included the highly sensitive L1210 in vitro assay. But be requiring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e29a893a7b78f4577a46e96d3e8bc360
https://doi.org/10.1159/000401468
https://doi.org/10.1159/000401468
Autor:
D. T. Gish, R. L. Griffin, A. J. Gibbons, L. G. Gray, Margaret E. Greig, G. L. Neil, G. D. Gray, S. L. Kuentzel, T. E. Moxley, William J. Wechter
Publikováno v:
Journal of Medicinal Chemistry. 19:1013-1017
Water-soluble derivatives of ara-cytidine (cytarabine, Cytosar) were prepared and tested for antitumor, immunosuppressive, and antiarthritic activities in animals after oral administration. The compounds tested included the 5'-palmitate, 5'-benzoate,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d69824ce819876d65f8848be3b31b2c
https://doi.org/10.1021/jm00230a007
https://doi.org/10.1021/jm00230a007
Autor:
A. H. Wenzel, Donald T. Warner, C. M. Hall, Margaret A. Johnson, A. E. Berger, G. L. Neil, D. T. Gish, William J. Wechter
Publikováno v:
Journal of Medicinal Chemistry. 18:339-344
This manuscript if one of a series of investigations into modifying the pharmacologic properties of the antitumor, antiviral, and immunosuppressive nucleoside ara-cytidine (cytarabine, Cytosar). The present paper summarizes our studies on depot ester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a9e81563aaabac2f47caeaf815793ca
https://doi.org/10.1021/jm00238a003
https://doi.org/10.1021/jm00238a003
Autor:
G. L. Neil, Robert H. Earhart
Publikováno v:
Advances in Enzyme Regulation. 24:179-205
This review, as its title indicates, views acivicin at a particular point in the ongoing process of its development. There is a large body of biochemical information which permits the formulation of a number of hypotheses regarding the drug's optimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58901ff4ac2c4c3f7e3c0c49399074bb
https://doi.org/10.1016/0065-2571(85)90076-7
https://doi.org/10.1016/0065-2571(85)90076-7
Autor:
T. E. Moxley, F.Richard Nichol, Gerald W. Camiener, William J. Wechter, Mary M. Mickelson, Kelly Robert C, D. T. Gish, G. L. Neil, Gary D. Gray
Publikováno v:
Biochemical Pharmacology. 21:465-475
Although cytarabine (cytosine arabinoside, ara -cytidine, Cytosar) is a potent immunosuppressant, antiviral and antitumor agent in animals and man, maximum inhibitory effects require the use of complex injection schedules. Previous reports have shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f5e6c21c7f07477b7c9579734cd8fe
https://doi.org/10.1016/0006-2952(72)90319-x
https://doi.org/10.1016/0006-2952(72)90319-x
Publikováno v:
Journal of Medicinal Chemistry. 15:790-792
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bd5af70d8bed0b57f4c5a521eebb1a2
https://doi.org/10.1021/jm00278a002
https://doi.org/10.1021/jm00278a002
Publikováno v:
Cancer research. 37(6)
Chartreusin has exhibited significant therapeutic activity against three experimental mouse tumors (ascitic P388, L1210 leukemia, and B16 melanoma) when tumor cells were inoculated i.p. and drug was administered i.p. In further testing against P388 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b301619a806d186355c70a63b7ac8df
https://pubmed.ncbi.nlm.nih.gov/870180
https://pubmed.ncbi.nlm.nih.gov/870180
Publikováno v:
Cancer treatment reports. 63(3)
The antimetabolite antibiotic L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) showed significant antitumor activity against L1210 and P388 mouse leukemias and the M5076 mouse ovarian tumor. Depending on the schedule of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4e9d157567ff20cb7b25e6765fa4910
https://pubmed.ncbi.nlm.nih.gov/427827
https://pubmed.ncbi.nlm.nih.gov/427827
Autor:
M, Williams, G L, Neil
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aea69390bf6b63f2afec10c797eb4669
https://pubmed.ncbi.nlm.nih.gov/3064185
https://pubmed.ncbi.nlm.nih.gov/3064185
Publikováno v:
Antibiotics and chemotherapy. 23
By utilizing new types of producing microorganisms and isolating these on rather unusual growth media, we hope to produce new classes of antitumor drugs. In the detection system, we included the highly sensitive L1210 in vitro assay. But be requiring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d95765caef14adf3389ba8c34d55000e
https://pubmed.ncbi.nlm.nih.gov/565613
https://pubmed.ncbi.nlm.nih.gov/565613