Zobrazeno 1 - 10
of 17
pro vyhledávání: '"G L, Kucera"'
Publikováno v:
Journal of Biological Chemistry. 266:1652-1655
We have examined the activation of phospholipase D in human platelets treated with alpha-thrombin. When incubated with 1-O-[9,10-3H2]hexadecyl-2-lysophosphatidylcholine (PtdCho) and 1-alkyl-[32P]lysoPtdCho for 2 h, platelets formed 3H/32P-labeled Ptd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60d8c6cbc00eeab4ca6d976cb3f1a781
https://doi.org/10.1016/s0021-9258(18)52344-9
https://doi.org/10.1016/s0021-9258(18)52344-9
Autor:
G. L. Kucera, S E Rittenhouse
Publikováno v:
Journal of Biological Chemistry. 265:5345-5348
Human platelets stimulated with alpha-thrombin or the thromboxane A2 analogue U46619 form the novel phosphatidylinositol (PtdIns) polyphosphate species PtdIns (3,4)P2 and PtdIns(3,4,5)P3 in a time- and dose-dependent manner. In [32P]o-phosphate-label
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acb26cc7fed06199a37e0f514b6902b7
https://doi.org/10.1016/s0021-9258(19)39361-5
https://doi.org/10.1016/s0021-9258(19)39361-5
Publikováno v:
Biochemical Journal. 265:747-754
To investigate the mechanism of enhanced responsiveness of cholesterol-enriched human platelets, we compared stimulation by surface-membrane-receptor (thrombin) and post-receptor (AlF4-) G-protein-directed pathways. Platelets were labelled with [32P]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631f85c0c84e27986969284a0df6dd07
https://doi.org/10.1042/bj2650747
https://doi.org/10.1042/bj2650747
Publikováno v:
Apoptosis : an international journal on programmed cell death. 3(6)
A variety of chemotherapeutic agents induce cell death via apoptosis. We had shown previously that gemcitabine (2',2'-difluorodeoxycytidine) induced an atypical apoptosis in BG-1 human ovarian cancer cells; therefore, further studies were conducted t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4de64af8dafe3b51c261cb16b729fea7
https://pubmed.ncbi.nlm.nih.gov/14646477
https://pubmed.ncbi.nlm.nih.gov/14646477
Publikováno v:
Oncology research. 10(7)
Protein kinase C (PKC) signaling pathways play an important role in cell survival and anticancer drug-induced apoptosis. We observed in clonogenicity assays of BG-1 human ovarian cancer cells that gemcitabine cytotoxicity was increased synergisticall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93be08f30d2841faf1ce720f77252f5f
https://pubmed.ncbi.nlm.nih.gov/10063971
https://pubmed.ncbi.nlm.nih.gov/10063971
Publikováno v:
Bone marrow transplantation. 17(4)
Twenty patients with a variety of neoplastic diseases were treated with preparative regimens containing high-dose cyclophosphamide (CY) administered as a 2-h infusion (60 mg/kg) for 2 days or by continuous infusion (1500 mg/m2/day) for 4 days. In pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ac95e8814abcf9be60b6dec63a1c8a7e
https://pubmed.ncbi.nlm.nih.gov/8722345
https://pubmed.ncbi.nlm.nih.gov/8722345
Publikováno v:
Leukemia. 9(3)
In preparation for a clinical trial using GM-CSF on days 4-10 of sequential high-dose cytarabine (ara-C) and asparaginase (ASNase) on days 1-3 and 8-10, potential interactions between the protein synthesis inhibitor ASNase and GM-CSF were evaluated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44570b4da487e55a45ba58e32600b7a5
https://pubmed.ncbi.nlm.nih.gov/7885038
https://pubmed.ncbi.nlm.nih.gov/7885038
Autor:
A. Thomas, L. McWilliams, G. L. Kucera, Joshua D. Waltonen, J. D. Browne, Christopher A. Sullivan, R. Plasser, M. Porosnicu
Publikováno v:
Journal of Clinical Oncology. 29:5568-5568
5568 Background: Strategies for early detection of cellular response to EGFR inhibitors are critical to personalizing therapy for SCCHN. The glycolytic enzymes responsible for uptake of the positro...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67bdc77c238cb1d66df91d46a80c9225
https://doi.org/10.1200/jco.2011.29.15_suppl.5568
https://doi.org/10.1200/jco.2011.29.15_suppl.5568
Autor:
G L, Kucera, R L, Capizzi
Publikováno v:
Cancer research. 52(14)
In an effort to identify the pathway leading to the formation of 1-beta-D-arabinofuranosylcytosine-diphosphate (ara-CDP)-choline from 1-beta-D-arabinofuranosylcytosine (ara-C) treatment of cultured cells, as well as of cells obtained from leukemia pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5d50d63bdcb1dbe847a4703ef97ab7e
https://pubmed.ncbi.nlm.nih.gov/1377599
https://pubmed.ncbi.nlm.nih.gov/1377599
Publikováno v:
The Biochemical journal. 278
We have shown that platelets stimulated with thrombin or guanosine 5′-[gamma-thio]triphosphate (GTP[S]), both of which activate phospholipase C and protein kinase C (PKC), show enhancement of 3-phosphorylated phosphoinositide accumulation (3-PPI).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2ef9ec1b71b5558244a3c6730f4ce1
https://pubmed.ncbi.nlm.nih.gov/1716881
https://pubmed.ncbi.nlm.nih.gov/1716881