Zobrazeno 1 - 10
of 38
pro vyhledávání: '"G L, Griffiths"'
Publikováno v:
The Journal of Immunology. 154:5919-5926
A natural N-linked glycosylation site (Asn-Val-Thr) at amino acid positions 18-20 (Kabat's numbering) was identified in the framework-1 (FR-1) region of the light chain variable (V kappa) domain of a murine anti-B cell lymphoma Ab, LL-2. Our earlier
Autor:
R, Stein, S V, Govindan, S, Chen, L, Reed, H, Richel, G L, Griffiths, H J, Hansen, D M, Goldenberg
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 42(6)
Tumor targeting and therapeutic efficacy of (177)Lu-labeled monoclonal antibody (mAb) RS7 (antiepithelial glycoprotein-1) was evaluated in a human nonsmall cell lung carcinoma xenograft model. The potential of (177)Lu-labeled RS7 was compared with th
Autor:
S V, Govindan, D M, Goldenberg, S E, Elsamra, G L, Griffiths, G L, Ong, M W, Brechbiel, J, Burton, G, Sgouros, M J, Mattes
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 41(12)
We demonstrated previously that human B-cell lymphomas were effectively and specifically killed in vitro by an antibody to CD74 (LL1) linked to (111)In or other Auger electron emitters. This study was intended to more accurately compare the potency a
Autor:
R, Stein, S V, Govindan, M J, Mattes, L B, Shih, G L, Griffiths, H J, Hansen, D M, Goldenberg
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5
A new nonmetabolizable peptide approach to the production of residualizing radioiodine was evaluated in nude mice bearing xenografts of human lung adenocarcinoma (Calu-3) and B-cell lymphoma (Ramos). Monoclonal antibodies (MAbs) RS7 (anti-epithelial
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5
The goal of this work was to test whether an antibody-based agent approved for use as a single-photon-emitting imaging agent when radiolabeled with technetium-99m could be labeled comparably with a positron-emitting nuclide, technetium-94m. "Instant
Publikováno v:
International journal of cancer. 81(6)
We investigated the in vitro cytotoxic potential of Auger electron-emitting radionuclides delivered to the cytoplasm or, more specifically, to lysosomes, via antibodies. The antibody (Ab) used was LL1, which is specific for CD74, an epitope of the ma
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 39(1)
The biodistribution, pharmacokinetics and dosimetry of 188Re-labeled MN-14, an IgG anti-carcinoembryonic antigen monoclonal antibody (MAb), were assessed in patients in advanced gastrointestinal cancer. In addition, the dose-limiting toxicity (DLT) a
Autor:
T M, Behr, R M, Sharkey, G, Sgouros, R D, Blumenthal, R M, Dunn, K, Kolbert, G L, Griffiths, J A, Siegel, W S, Becker, D M, Goldenberg
Publikováno v:
Cancer. 80
Elevated renal uptake and extended retention of radiolabeled antibody fragments and peptides is a problem in the therapeutic application of such agents. However, cationic amino acids have been shown to reduce renal accretion. The aims of the current
Autor:
R M, Sharkey, R D, Blumenthal, T M, Behr, G Y, Wong, L, Haywood, D, Forman, G L, Griffiths, D M, Goldenberg
Publikováno v:
International journal of cancer. 72(3)
In order to optimize radioimmunotherapy (RAIT) as a cancer-treatment modality, it is necessary to select the appropriate radionuclide and antibody carrier. We evaluated the therapeutic potential of a single cycle of Mu-9 anti-CSAp monoclonal antibody
Autor:
R M, Sharkey, M, Juweid, J, Shevitz, T, Behr, R, Dunn, L C, Swayne, G Y, Wong, R D, Blumenthal, G L, Griffiths, J A, Siegel
Publikováno v:
Cancer research. 55
A complementarity-determining region-grafted (humanized) version of MN-14 (hMN-14), a high-affinity, anti-carcinoembryonic antigen (CEA) murine monoclonal antibody (mMAb), was selected from several clones that differed slightly in their framework com