Zobrazeno 1 - 10
of 30
pro vyhledávání: '"G L, Chan"'
Autor:
Bill W. G. L. Chan, Nicholas B. Lynch, Wendy Tran, Jack M. Joyce, G. Paul Savage, Wim Meutermans, Andrew P. Montgomery, Michael Kassiou
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Fragment-based drug discovery (FBDD) has emerged as a powerful strategy to confront the challenges faced by conventional drug development approaches, particularly in the context of central nervous system (CNS) disorders. FBDD involves the screening o
Externí odkaz:
https://doaj.org/article/fa640cc91f804f6ab374989d624f7f85
Autor:
S M, Wong, S X, Tung, Q S, Wong, Y Y, Tso, J R, Ho, Z B, Chow, L N, Lam, F Y, Chan, H F, Cheng, G L, Chan, B B, Ip
Publikováno v:
Zhonghua er ke za zhi = Chinese journal of pediatrics. 56(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f633dac116965c9b7f6bc7eedf5c50a0
https://pubmed.ncbi.nlm.nih.gov/29429199
https://pubmed.ncbi.nlm.nih.gov/29429199
Publikováno v:
Cardiovascular Surgery. 3:325-329
A retrospective analysis to evaluate the impact of prior sternotomy on the outcome of cardiac transplantation was undertaken. Some 165 patients who received primary heart transplantation were classified into three groups. There were 102 patients in g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cfbe92db877b17a3a318d07f390196b
https://doi.org/10.1016/0967-2109(95)93885-s
https://doi.org/10.1016/0967-2109(95)93885-s
Publikováno v:
Cardiovascular Surgery. 3:331-335
Critically ill patient status and prior sternotomy have separately been associated with increased risk of mortality and morbidity after heart transplantation. Consequently, the justification of assigning urgent priority for transplantation to critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f7d153e8ca3fe48c968535dfffaf81d
https://doi.org/10.1016/0967-2109(95)93886-t
https://doi.org/10.1016/0967-2109(95)93886-t
Autor:
G L, Chan, J E, Holden, A J, Stoessl, A, Samii, D J, Doudet, T, Dobko, K S, Morrison, M, Adam, M, Schulzer, D B, Calne, T J, Ruth
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 40(2)
The reproducibility of (+/-)-alpha-[11C] dihydrotetrabenazine (DTBZ) measures in PET was studied in 10 healthy human subjects, aged 22-76 y.The scan-to-scan variation of several measures used in PET data analysis was determined, including the radioac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd6209517f2629475ab4a2853e505ed4
https://pubmed.ncbi.nlm.nih.gov/10025836
https://pubmed.ncbi.nlm.nih.gov/10025836
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 39(10)
The aim of this study was to test the quantitation accuracy of three-dimensional PET in brain scanning.Three-dimensional data from 11 human subjects were tested using 11C-dihydrotetrabenazine, 11C-Schering 23390 and 18F-FDG as tracers. Two-dimensiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8581c2edc1dce47ebc9521bac446b84
https://pubmed.ncbi.nlm.nih.gov/9776275
https://pubmed.ncbi.nlm.nih.gov/9776275
Autor:
Y, Wang, G L, Chan, J E, Holden, T, Dobko, E, Mak, M, Schulzer, J M, Huser, B J, Snow, T J, Ruth, D B, Calne, A J, Stoessl
Publikováno v:
Synapse (New York, N.Y.). 30(1)
Radioligand binding studies in animals have demonstrated age-related loss of dopamine receptors in the caudate and putamen. In humans, while age-related declines in dopamine D2 receptors have been consistently reported, the effects of ageing on D1 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a8be0e754fd8a1781878779f837af0f
https://pubmed.ncbi.nlm.nih.gov/9704881
https://pubmed.ncbi.nlm.nih.gov/9704881
6-[18F]Fluoro-L-DOPA PET studies of the turnover of dopamine in MPTP-induced parkinsonism in monkeys
Publikováno v:
Synapse (New York, N.Y.). 29(3)
This report describes a method to assess, in vivo, the turnover of dopamine (DA) and describes its application to the evaluation of DA function in normal monkeys and monkeys with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced lesions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5b521f666b5b7f036408ecda1b1c3c2
https://pubmed.ncbi.nlm.nih.gov/9635892
https://pubmed.ncbi.nlm.nih.gov/9635892
Autor:
G L, Chan, J E, Holden, A J, Stoessl, D J, Doudet, Y, Wang, T, Dobko, K S, Morrison, J M, Huser, C, English, B, Legg, M, Schulzer, D B, Calne, T J, Ruth
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 39(5)
The reproducibility of [11C]SCH 23390 in PET was studied in 10 normal human subjects.The scan-to-scan variation of several measures used in PET data analysis, including the radioactivity ratio, plasma-input Logan total distribution volume (DV), plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06596bc267ffe661bbdcacb10ec391f9
https://pubmed.ncbi.nlm.nih.gov/9591577
https://pubmed.ncbi.nlm.nih.gov/9591577
Publikováno v:
European journal of pharmacology. 334(1)
The consequences of monoamine oxidase and catechol-O-methyltransferase inhibition on the effective turnover of dopamine were investigated using 6-[18F]L-3-4-dihydroxyphenylalanine (6-[18F]L-DOPA) and positron emission tomography. The effective dopami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf2c7eb9c6a76045d5af381f92eb4150
https://pubmed.ncbi.nlm.nih.gov/9346324
https://pubmed.ncbi.nlm.nih.gov/9346324