Výsledky vyhledávání

Human Growth Hormone Deletion Mutant (hGH44-191) Binds with High Affinity to Lactogenic Receptors but Not to Somatogenic Receptors

Autor: Andrew O. Martinez, Urban J. Lewis, N.R. Staten, Gwen G. Krivi, Luis S. Haro, R. N. P. Singh, S.S. Galosy

Publikováno v: Biochemical and Biophysical Research Communications. 222:421-426

The carboxyl-terminal hGH fragment, hGH 44–191 , displays diabetogenic activity. To understand whether this biological activity is mediated through somatogenic or lactogenic receptors, we investigated the ability of hGH 44–191 to bind both recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88103e036db5709a44927acf4c2fdb8
https://doi.org/10.1006/bbrc.1996.0760

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Molecular cloning and expression of human leukotriene-C4 synthase

Autor: Scott D. Hauser, Peter C. Isakson, Karl J. Mathis, Dean J. Welsch, David Paul Creely, Gwen G. Krivi

Publikováno v: Proceedings of the National Academy of Sciences. 91:9745-9749

Leukotriene-C4 synthase (LTC4S; EC 2.5.1.37) catalyzes the committed step in the biosynthesis of the peptidoleukotrienes, which are important in the pathogenesis of asthma. Antibodies were generated to a synthetic peptide based on the partial amino a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63b9baa98c097c24a4a4a38075c7ebb
https://doi.org/10.1073/pnas.91.21.9745

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Pharmacokinetic and galactopoietic response to recombinant variants of bovine growth hormone

Autor: T.C. White, Robert J. Collier, W. J. Salsgiver, B. K. Birmingham, L. A. Bentle, Gregory Lanza, S. Ganguli, M.A. Miller, P.J. Eppard, M. D. Hale, D C Wood, Gwen G. Krivi, R.L. Hintz, E. Rowold

Publikováno v: Journal of Endocrinology. 139:441-450

Two studies were designed to examine the pharmacokinetic and galactopoietic potency of three molecular variants of recombinant-derived bovine GH (rbGH): [Met1, Leu127]-bGH, [Ala1, Val127]-bGH and [Ala1, Val127, His133]-bGH. Histidine substitution for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3749a7b28239ec89689775ce7322cfea
https://doi.org/10.1677/joe.0.1390441

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High-Level Expression and Purification of Human Leukotriene A4 Hydrolase from Insect Cells Infected with a Baculovirus Vector

Autor: Serdar Aykent, K.L. Duffin, N.M. Kimack, G.S. Bild, Gwen G. Krivi, M.J. Bourner, L.J. Askonas, C.P. Rodi, P.M. Sullivan, James K. Gierse, V.A. Luckow

Publikováno v: Protein Expression and Purification. 4:358-366

Leukotrienes constitute a group of bioactive compounds derived from arachidonic acid which play important roles in immediate hypersensitivity and inflammation. Leukotriene A 4 hydrolase (LTA 4 H) is an epoxide hydrolase, catalyzing the hydration of L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6caf223ddfb855e157b773b34064e6d5
https://doi.org/10.1006/prep.1993.1047

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Ligand-specific dimerization of the extracellular domain of the bovine growth hormone receptor

Autor: John C. Byatt, N.R. Staten, Gwen G. Krivi

Publikováno v: Journal of Biological Chemistry. 268:18467-18473

The bovine growth hormone (bGH) receptor and its extracellular domain (bGHBP) bind two protein hormones with high affinity; bGH and bovine placental lactogen (bPL). However, each of these hormones bind with a different stoichiometry. bGH binds to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f15f7475ae84b088e8c5bd0db60be89
https://doi.org/10.1016/s0021-9258(17)46649-x

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Adipsin expression and growth in rats as influenced by insulin and somatotropin

Autor: John C. Byatt, Clifton A. Baile, Jess L. Miner, Gwen G. Krivi

Publikováno v: Physiology & Behavior. 54:207-212

Adipsin is a molecular marker of obesity in rodents. Content of adipsin protein in blood and mRNA in adipocytes is significantly reduced in several genetic and experimentally induced obese models. It has been suggested that this reduction in adipsin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5722c80262e7ba39af391a5cfe5e7737
https://doi.org/10.1016/0031-9384(93)90100-t

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Immunohistochemical and Nucleic Acid Analysis of Somatotropin Receptor Populations in the Bovine Ovary

Autor: Matthew C. Lucy, Robert J. Collier, Gwen G. Krivi, Julia J. Dibner, Scott D. Hauser, Marianne L. Kitchell

Publikováno v: Biology of Reproduction. 48:1219-1227

Ovaries were analyzed for somatotropin receptor protein and mRNA through use of immunohistochemistry, solution hybridization/nuclease protection, Northern blotting, and reverse transcriptase polymerase chain reaction (RT-PCR). As indicated by immunop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7c5849c03f8f67be8648a38993d077
https://doi.org/10.1095/biolreprod48.6.1219

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Mechanism-based inactivation of leukotriene A4 hydrolase/aminopeptidase by leukotriene A4. Mass spectrometric and kinetic characterization

Autor: G Krivi, Lars Orning, K Duffin, G Bild, Frank A. Fitzpatrick, James K. Gierse

Publikováno v: Journal of Biological Chemistry. 267:22733-22739

"Suicide" inactivation of leukotriene (LT) A4 hydrolase/aminopeptidase occurs via an irreversible mechanism-based process which is saturable, of pseudo firstorder, and dependent upon catalysis. Data obtained with either recombinant enzyme or enzyme p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7e3130c349913267d8a5290c6b96950
https://doi.org/10.1016/s0021-9258(18)50009-0

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