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Akademický článek

Covariate modeling in pharmacometrics: General points for consideration

Autor: Kinjal Sanghavi, Jakob Ribbing, James A. Rogers, Mariam A. Ahmed, Mats O. Karlsson, Nick Holford, Estelle Chasseloup, Malidi Ahamadi, Kenneth G. Kowalski, Susan Cole, Essam Kerwash, Janet R. Wade, Chao Liu, Yaning Wang, Mirjam N. Trame, Hao Zhu, Justin J. Wilkins, for the ISoP Standards & Best Practices Committee

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 5, Pp 710-728 (2024)

Abstract Modeling the relationships between covariates and pharmacometric model parameters is a central feature of pharmacometric analyses. The information obtained from covariate modeling may be used for dose selection, dose individualization, or th

Externí odkaz: https://doaj.org/article/480b15b1cc5a4b0f8e7434ed8c4d630f

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Akademický článek

Antitangling and manufacturable Fog Harps for high‐efficiency water harvesting

Autor: Jimmy K. Kaindu, Kevin R. Murphy, Nicholas G. Kowalski, Alexandra N. Jones, Matthew Davis Fleming, Brook S. Kennedy, Jonathan B. Boreyko

Publikováno v: Droplet, Vol 2, Iss 4, Pp n/a-n/a (2023)

Abstract Fog Harps harvest substantially more water than conventional mesh‐based harvesters. However, to date, all large‐scale Fog Harps have been impractically hand‐wound at low wire tensions and suffer from elastocapillary wire tangling. Here

Externí odkaz: https://doaj.org/article/cc6f05aa3dfc4cb0b8c8e2e4b1eeb81c

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Akademický článek

Population pharmacokinetics and standard uptake value ratio of aducanumab, an amyloid plaque–removing agent, in patients with Alzheimer’s disease

Autor: Kumar Kandadi Muralidharan, Xiao Tong, Kenneth G. Kowalski, Raj Rajagovindan, Lin Lin, Samantha Budd Haberlain, Ivan Nestorov

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 1, Pp 7-19 (2022)

Abstract Aducanumab is a human immunoglobulin G1 anti‐amyloid beta (Aβ) antibody currently being evaluated for potential treatment of patients with early Alzheimer’s disease. This paper describes the relationship between the population pharmacok

Externí odkaz: https://doaj.org/article/6a0a7cf76a734c6fab8a7a9f6a676938

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Akademický článek

Editorial: Blood-Based Biomarkers in Acute Ischemic Stroke and Hemorrhagic Stroke

Autor: Timo Uphaus, Heinrich J. Audebert, Michael W. Graner, Steffen Tiedt, Robert G. Kowalski

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

Externí odkaz: https://doaj.org/article/3ee4709a3b324596a0c324a177c3a8b6

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Akademický článek

Phenotype and Neuronal Cytotoxic Function of Glioblastoma Extracellular Vesicles

Autor: Wenbo Zhou, Daniel Lovasz, Zoë Zizzo, Qianbin He, Christina Coughlan, Robert G. Kowalski, Peter G. E. Kennedy, Arin N. Graner, Kevin O. Lillehei, D. Ryan Ormond, A. Samy Youssef, Michael W. Graner, Xiaoli Yu

Publikováno v: Biomedicines, Vol 10, Iss 11, p 2718 (2022)

Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. Extracellular vesicles (EVs) released by tumor cells play a critical role in cellular communication in the tumor microenvironment promoting tumor progression and invasion. We h

Externí odkaz: https://doaj.org/article/b53e63a22e594d2e9d6b55cbb8a35846

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Characterization of exposure–Clinical Dementia Rating–Sum of Boxes relationship in subjects with early Alzheimer’s disease from the aducanumab Phase 3 trials

Autor: Kumar Kandadi Muralidharan, Kenneth G. Kowalski, Xiao Tong, Samantha Budd Haeberlein, Rajasimhan Rajagovindan, Ivan Nestorov

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics. 50:45-62

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca54b16e0d9ecd18d92b8dbb2747d2c5
https://doi.org/10.1007/s10928-022-09839-3

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Akademický článek

Living in the 'Age of Humans'. Envisioning CAD Architecture for the Challenges of the Anthropocene—Energy, Environment, and Well-Being

Autor: Krystyna Januszkiewicz, Natalia Paszkowska-Kaczmarek, Fekadu Aduna Duguma, Karol G. Kowalski

Publikováno v: Energies, Vol 14, Iss 19, p 6093 (2021)

The Anthropocene thesis poses new challenges to human activity on the planet. These challenges also apply to the built environment. Climate change will increase existing threats, and create new ones, for both human and natural systems. Above all, the

Externí odkaz: https://doaj.org/article/a644ca60ed8848c5b93ffe6a4f610d2c

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