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Exploring dyserythropoiesis in patients with myelodysplastic syndrome by imaging flow cytometry and machine-learning assisted morphometrics

Autor: Carina A. Rosenberg, Mathias Hauerslev, Matthew A. Rodrigues, Marie Bill, G. Kerndrup, Maja Ludvigsen, Peter Hokland

Publikováno v: Rosenberg, C A, Bill, M, Rodrigues, M A, Hauerslev, M, Kerndrup, G B, Hokland, P & Ludvigsen, M 2021, ' Exploring dyserythropoiesis in patients with myelodysplastic syndrome by imaging flow cytometry and machine-learning assisted morphometrics ', Cytometry. Part B: Clinical Cytometry, vol. 100, no. 5, pp. 554-567 . https://doi.org/10.1002/cyto.b.21975

BACKGROUND: The hallmark of myelodysplastic syndrome (MDS) remains dysplasia in the bone marrow (BM). However, diagnosing MDS may be challenging and subject to inter-observer variability. Thus, there is an unmet need for novel objective, standardized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8d2fa38a1f574f15b9e40d1ef7331a
https://pure.au.dk/portal/da/publications/exploring-dyserythropoiesis-in-patients-with-myelodysplastic-syndrome-by-imaging-flow-cytometry-and-machinelearning-assisted-morphometrics(0adc6867-29ac-4629-99dd-6cec2508e532).html

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Clonal hematopoiesis predicts development of therapy-related myeloid neoplasms post-autologous stem cell transplantation

Autor: Marcus Celik Hansen, Maja Ludvigsen, Ina Kathrine Lykke Ewald, G. Kerndrup, Johannes Frasez Soerensen, Marie Bill, Peter Hokland, Lene Hyldahl Ebbesen, Anne Stidsholt Roug, Carina A. Rosenberg, Anni Aggerholm

Publikováno v: Soerensen, J F, Aggerholm, A, Kerndrup, G B, Hansen, M C, Ewald, I K L, Bill, M, Ebbesen, L H, Rosenberg, C A, Hokland, P, Ludvigsen, M & Stidsholt Roug, A 2020, ' Clonal hematopoiesis predicts development of therapy-related myeloid neoplasms post-autologous stem cell transplantation ', Blood advances, vol. 4, no. 5, pp. 885-892 . https://doi.org/10.1182/bloodadvances.2019001157
Soerensen, J F, Aggerholm, A, Kerndrup, G B, Hansen, M C, Ewald, I K L, Bill, M, Ebbesen, L H, Rosenberg, C A, Hokland, P, Ludvigsen, M & Stidsholt Roug, A 2020, ' Clonal hematopoiesis predicts development of therapy-related myeloid neoplasms post-autologous stem cell transplantation ', Blood Advances, vol. 4, no. 5, pp. 885-892 . https://doi.org/10.1182/bloodadvances.2019001157

Therapy-related myeloid neoplasms (tMN) develop after exposure to cytotoxic and radiation therapy, and due to their adverse prognosis, it is of paramount interest to identify patients at high risk. The presence of clonal hematopoiesis has been shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3dfa61d6b3a49c67ea473f48530d20e
https://vbn.aau.dk/ws/files/336993392/advancesadv2019001157.pdf

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Clonal Hematopoiesis Drives Therapy-Related Myeloid Neoplasms Following Autologous Stem Cell Transplantation and Propagates during Disease Evolution

Autor: Johannes Frasez Sørensen, Maja Ludvigsen, Peter Hokland, Anne Stidsholt Roug, G. Kerndrup, Marcus Høy Hansen, Lene Hyldahl Ebbesen, Anni Aggerholm

Publikováno v: Blood. 136:15-16

Introduction: Clonal hematopoiesis (CH) denotes somatic mutations in genes related to myeloid neoplasms present at any variant allele frequency (VAF). Clonal hematopoiesis increases the risk of cardiovascular disease, de novo myeloid neoplasms and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19d427cec65c3cae7d99674e2e4cf5b5
https://doi.org/10.1182/blood-2020-141993

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Rare MLL-ELL fusion transcripts in childhood acute myeloid leukemia—association with young age and myeloid sarcomas?

Autor: Signe Spetalen, Bernward Zeller, Ludmila Gorunova, Lil Sofie Ording Müller, Marit Hellebostad, G. Kerndrup, Anne Tierens, Sverre Heim, Ioannis Panagopoulos, Liv T. N. Osnes, Kristin Andersen

Publikováno v: Experimental Hematology & Oncology

Background The chromosomal translocation t(11;19)(q23;p13) with a breakpoint within subband 19p13.1 is found mainly in acute myeloid leukemia (AML) and results in the MLL-ELL fusion gene. Variations in the structure of MLL-ELL seem to influence the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3919ec18afd901039ee27ad310a15c73
http://hdl.handle.net/10852/49666

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Exploring Imaging Flow Cytometry As a Tool for Evaluating Dyserythropoiesis in Myelodysplastic Syndrome

Autor: Mathias Hauerslev, Marie Bill, Carina A. Rosenberg, Peter Hokland, G. Kerndrup, Maja Ludvigsen

Publikováno v: Blood. 132:5508-5508

Introduction In myelodysplastic syndrome (MDS), multicolor flow cytometry (FC) offers a supplement to the morphological, cytogenetic and molecular evaluation of the hematopoietic lineages in the bone marrow (BM). In addition to providing a robust enu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cead213c265bf517782ac66df8b52827
https://doi.org/10.1182/blood-2018-99-111555

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A Clinicopathological Study of 13 Danish Cases of Burkitt's Lymphoma

Autor: G. Pallesen, G. Kerndrup

Publikováno v: Scandinavian Journal of Haematology. 27:99-107

During a 4-year period 24 cases of malignant non-Hodgkin's lymphomas were proposed to be of the Burkitt-type (BL) by at least 1 of 5 pathologists of the lymphoma Registry in Jutland, Denmark. When the histological material was critically reviewed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb5f6f9262760e1a065b8e008379928
https://doi.org/10.1111/j.1600-0609.1981.tb00458.x

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Novel mutation of the LPIN2 gene in Turkish brothers with Majeed syndrome. Response to IL-1 inhibition

Autor: Troels Herlin, Bente Fiirgaard, Henrik Hasle, Polly J. Ferguson, G Kerndrup, Mette Bjerre

Publikováno v: Pediatric Rheumatology Online Journal, Vol 9, Iss Suppl 1, p P300 (2011)
Pediatric Rheumatology Online Journal

Background Majeed syndrome is a rare, syndromic form of chronic recurrent multifocal osteomyelitis (CRMO) first described in 1989. The syndrome starts during infancy with recurrent relapses of osteomyelitis typically associated with fever, congenital

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802c69c66b71dcd8d6d7ea89f3c5108c
https://doaj.org/article/303b8527126e4a44beb9d50922a20501

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Clonal Mutational Landscape of Childhood Myelodysplastic Syndromes

Publikováno v: Blood. 126:1662-1662

Childhood myelodysplastic syndromes (MDS) belong to a rare group of disorders of aberrant clonal hematopoiesis manifesting throughout entire childhood and adolescence. We had previously established that GATA2 germline mutations can be considered the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c080050599278442579c1c35c737de51
https://doi.org/10.1182/blood.v126.23.1662.1662

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Autotransplantation of splenic tissue in an isolated segment of small intestine

Autor: M. Bayat, S. Rahimi-Saber, G. Kerndrup, S. Lindkaer Jensen, M. H. Shokouh-Amiri

Publikováno v: British Journal of Surgery. 79:1327-1329

The ability of splenic tissue to regenerate when implanted in an isolated segment of small intestine with intact circulation was studied in six pigs. After total splenectomy, 10 per cent of the weight of the spleen was implanted in a 10–15-cm long

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71dbbc9f31cc5b5a49ac01e6f2331311
https://doi.org/10.1002/bjs.1800791228

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