Výsledky vyhledávání - "G Kenneth Gray"

Akademický článek

NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma.

Autor: Braden C McFarland, Suk W Hong, Rajani Rajbhandari, George B Twitty, G Kenneth Gray, Hao Yu, Etty N Benveniste, Susan E Nozell

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e78728 (2013)

Glioblastoma (GBM) is the most aggressive, neurologically destructive and deadly tumor of the central nervous system (CNS). In GBM, the transcription factors NF-κB and STAT3 are aberrantly activated and associated with tumor cell proliferation, surv

Externí odkaz: https://doaj.org/article/b5fc7ee2c43f4af49ac189a525edcf27

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Akademický článek

A transcriptional response to replication stress selectively expands a subset of Brca2-mutant mammary epithelial cells

Autor: Maryam Ghaderi Najafabadi, G. Kenneth Gray, Li Ren Kong, Komal Gupta, David Perera, Huw Naylor, Joan S. Brugge, Ashok R. Venkitaraman, Mona Shehata

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Germline BRCA2 mutation carriers frequently develop luminal-like breast cancers, but it remains unclear how BRCA2 mutations affect mammary epithelial subpopulations. Here, we report that monoallelic Brca2 mut/WT mammary organoids subjected t

Externí odkaz: https://doaj.org/article/f836acac45844291bd635b3b1255cb55

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Akademický článek

Single-cell and spatial analyses reveal a tradeoff between murine mammary proliferation and lineage programs associated with endocrine cues

Autor: G. Kenneth Gray, Nomeda Girnius, Hendrik J. Kuiken, Aylin Z. Henstridge, Joan S. Brugge

Publikováno v: Cell Reports, Vol 42, Iss 10, Pp 113293- (2023)

Summary: Although distinct epithelial cell types have been distinguished in glandular tissues such as the mammary gland, the extent of heterogeneity within each cell type and the degree of endocrine control of this diversity across development are in

Externí odkaz: https://doaj.org/article/9dbe35a7cfd941dda4fdbe809ea5cc9d

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