Zobrazeno 1 - 10
of 336
pro vyhledávání: '"G Kees, Hovingh"'
Autor:
Reindert F. Oostveen, Yannick Kaiser, Merel L. Hartgers, Emma C. E. Meessen, Aldo Grefhorst, G. Kees Hovingh, Folkert Kuipers, Erik S. G. Stroes, Albert K. Groen, Laurens F. Reeskamp
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 20 (2024)
Background The trans intestinal cholesterol excretion (TICE) pathway is a potential therapeutic target to reduce plasma low‐density lipoprotein (LDL) cholesterol levels. TICE encompasses the direct excretion of cholesterol by enterocytes into feces
Externí odkaz:
https://doaj.org/article/657e0bd088834806b65aaaa0e889e79d
Autor:
Marc R Dweck, Evangelos Tzolos, Nick S Nurmohamed, Yannick Kaiser, Erik S G Stroes, G Kees Hovingh, Jeffrey Kroon, Jolien Geers, Jordan M Kraaijenhof, Mo Meah
Publikováno v:
Open Heart, Vol 11, Iss 2 (2024)
Background Inflammation plays a pivotal role in atherogenesis and is a causal risk factor for atherosclerotic cardiovascular disease. Non-invasive coronary CT angiography (CCTA) enables evaluation of coronary plaque phenotype. This study investigates
Externí odkaz:
https://doaj.org/article/8efb3b27b1884672a4ec6b8472f6c913
Autor:
Jordan M. Kraaijenhof, Héléne T. Cronjé, G. Kees Hovingh, Nick S. Nurmohamed, Dipender Gill, Loukas Zagkos
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 12 (2024)
Externí odkaz:
https://doaj.org/article/ce4afd7541434e509f54df4e4fe15723
Autor:
Khurram Nasir, Reed Mszar, Miguel Cainzos-Achirica, Gowtham R. Grandhi, Tycho R. Tromp, Rodrigo Alonso, Márcio S. Bittencourt, Eric Bruckert, José Luis Díaz-Díaz, Antonio Gallo, G. Kees Hovingh, Marcio H. Miname, Ovidio Muñiz-Grijalvo, Jing Pang, Leopoldo Perez de Isla, Eric J.G. Sijbrands, Gerald F. Watts, Pedro Mata, Raul D. Santos
Publikováno v:
American Journal of Preventive Cardiology, Vol 17, Iss , Pp 100611- (2024)
Objectives: Individuals with familial hypercholesterolemia (FH) are at an increased risk for coronary artery disease (CAD). While prior research has shown variability in coronary artery calcification (CAC) among those with FH, studies with small samp
Externí odkaz:
https://doaj.org/article/02c543cadbc747008f4f6ac5cb02c969
Autor:
Héléne T. Cronjé, Ville Karhunen, G. Kees Hovingh, Ken Coppieters, Jens O. Lagerstedt, Michael Nyberg, Dipender Gill
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background C-type natriuretic peptide (CNP) is a known target for promoting growth and has been implicated as a therapeutic opportunity for the prevention and treatment of cardiovascular disease (CVD). This study aimed to explore the effect
Externí odkaz:
https://doaj.org/article/0d9080e5d8094a21b18b925771ec0af9
Autor:
Shirin Ibrahim, Nick S. Nurmohamed, Didier Collard, Anouk de Weger, G. Kees Hovingh, Bert‐Jan H. van den Born, Laurens F. Reeskamp, Erik S. G. Stroes, Tom F. Brouwer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 22 (2023)
Background Medication nonadherence contributes to poor health outcomes but remains challenging to identify. This study assessed the association between self‐rated adherence and systolic blood pressure, low‐density lipoprotein cholesterol levels,
Externí odkaz:
https://doaj.org/article/5518a4fd1e424e2bbc5c5fd76e2a17e4
Autor:
Jordan M. Kraaijenhof, Tycho R. Tromp, Nick S. Nurmohamed, Laurens F. Reeskamp, Marije Langenkamp, Johannes H. M. Levels, S. Matthijs Boekholdt, Nicholas J. Wareham, Menno Hoekstra, Erik S. G. Stroes, G. Kees Hovingh, Aldo Grefhorst
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 21 (2023)
Background ANGPTL3 (angiopoietin‐like protein 3) is an acknowledged crucial regulator of lipid metabolism by virtue of its inhibitory effect on lipoprotein lipase and endothelial lipase. It is currently unknown whether and to which lipoproteins ANG
Externí odkaz:
https://doaj.org/article/bafeced5a2c34d4aab76891c406e105f
Autor:
Jian Huang, Simon A Jones, Abbas Dehghan, Dipender Gill, Rainer Malik, Ari Ahola-Olli, Olli Raitakari, Veikko Salomaa, Terho Lehtimäki, Marko Salmi, Sirpa Jalkanen, Sirkka Keinänen-Kiukaanniemi, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Sylvain Sebert, Mark J Ponsford, Konstantinos K Tsilidis, Martin Dichgans, Ville Karhunen, Saranya Palaniswamy, G Kees Hovingh, Juha Veijola, Juha Auvinen, Markku Timonen, Emmanouil Bouras, Areti Papadopoulou, Matthias Wielscher
Publikováno v:
BMJ Medicine, Vol 2, Iss 1 (2023)
Objective To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets.Design Bi-directional Mendelian randomisation study.S
Externí odkaz:
https://doaj.org/article/ca123e8a43954a8190bcce6b00fdf891
Autor:
Marios K. Georgakis, Rainer Malik, Tom G. Richardson, Joanna M. M. Howson, Christopher D. Anderson, Stephen Burgess, G. Kees Hovingh, Martin Dichgans, Dipender Gill
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-7 (2022)
Abstract Background Interleukin 6 (IL-6) signaling is being investigated as a therapeutic target for atherosclerotic cardiovascular disease (CVD). While changes in circulating high-sensitivity C-reactive protein (hsCRP) are used as a marker of IL-6 s
Externí odkaz:
https://doaj.org/article/8c3064db81914a52b405218226df0f86
Autor:
Josefien W. Hommes, Rachel M. Kratofil, Sigrid Wahlen, Carla J. C. de Haas, Reeni B. Hildebrand, G. Kees Hovingh, Micheal Otto, Miranda van Eck, Menno Hoekstra, Suzanne J. A. Korporaal, Bas G. J. Surewaard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Staphylococcus aureus virulence has been associated with the production of phenol-soluble modulins (PSMs). These PSMs have distinct virulence functions and are known to activate, attract and lyse neutrophils. These PSM-associated biological
Externí odkaz:
https://doaj.org/article/d79e59c52eb7439aaa4c53dd098bcdb8