Zobrazeno 1 - 10
of 17
pro vyhledávání: '"G K Poon"'
Autor:
C Pagonis, D M Vigushin, Alan V. Boddy, G K Poon, J English, M Jarman, R C Coombes, Gavin Halbert
Publikováno v:
Cancer Chemotherapy and Pharmacology. 42:111-117
Purpose: d-Limonene is a natural monoterpene with pronounced chemotherapeutic activity and minimal toxicity in preclinical studies. A phase I clinical trial to assess toxicity, the maximum tolerated dose (MTD) and pharmacokinetics in patients with ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9314b1b55e7c4854337267b76ec3670c
https://doi.org/10.1007/s002800050793
https://doi.org/10.1007/s002800050793
Publikováno v:
Rapid Communications in Mass Spectrometry. 10:1165-1168
Liquid chromatography with an electrospray ionization (ESI) interface has been applied to study the anticancer drug taxol and its metabolites after incubation with human hepatic microsomes. The parent drug and its metabolites were monitored in the po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::744ccbdcebc986a8789aa92d82aab0ff
https://doi.org/10.1002/(sici)1097-0231(19960731)10:10<1165::aid-rcm608>3.0.co
https://doi.org/10.1002/(sici)1097-0231(19960731)10:10<1165::aid-rcm608>3.0.co
Publikováno v:
Analytical Chemistry. 68:668-674
On-line capillary electrophoresis-electrospray ionization mass spectrometry (CE-ESMS) has been employed for the analysis of metabolites of the anticancer drug tamoxifen. Nonaqueous (methanol) CE electrolyte provided better resolution and detection se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc08e7fb39b651631b79c957f907d94
https://doi.org/10.1021/ac950786x
https://doi.org/10.1021/ac950786x
Publikováno v:
Cell Biophysics. 22:9-26
Antibody-directed enzyme prodrug therapy (ADEPT) involves two phases. The first is an antibody-enzyme conjugate that localizes to tumor. The second phase is a prodrug that is administered when the enzyme-conjugate has cleared from blood and other non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b306663dfed9c80e97e0d2b137e498b
https://doi.org/10.1007/bf03033864
https://doi.org/10.1007/bf03033864
Autor:
G K, Poon, Q, Chen, Y, Teffera, J S, Ngui, P R, Griffin, M P, Braun, G A, Doss, C, Freeden, R A, Stearns, D C, Evans, T A, Baillie, W, Tang
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(12)
The metabolism of diclofenac has been reported to produce reactive benzoquinone imine intermediates. We describe the identification of mercapturic acid derivatives of diclofenac in rats and humans. Three male Sprague-Dawley rats were administered dic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86fcab61729b641734bcf789aa8eb8c9
https://pubmed.ncbi.nlm.nih.gov/11717180
https://pubmed.ncbi.nlm.nih.gov/11717180
Publikováno v:
Journal of AOAC International. 84(5)
Cyanobacteria (blue-green algae) produce a wide range of low molecular weight metabolites that include potent neurotoxins, hepatotoxins, and cytotoxins. The accumulation of such toxins in freshwaters, and in brackish and marine waters presents hazard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::617ea0e11afc6b9d18fbcef843093880
https://pubmed.ncbi.nlm.nih.gov/11601485
https://pubmed.ncbi.nlm.nih.gov/11601485
Publikováno v:
Rapid communications in mass spectrometry : RCM. 13(19)
During the early phase of a drug discovery process, in order to facilitate the selection of drug candidates from a discovery research program, a liquid chromatography tandem mass spectrometry (LC/MS/MS) strategy has been developed to assess the preli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6f983775cf74c92e0cb12db77e1add8
https://pubmed.ncbi.nlm.nih.gov/10487941
https://pubmed.ncbi.nlm.nih.gov/10487941
Autor:
D M, Vigushin, G K, Poon, A, Boddy, J, English, G W, Halbert, C, Pagonis, M, Jarman, R C, Coombes
Publikováno v:
Cancer chemotherapy and pharmacology. 42(2)
D-Limonene is a natural monoterpene with pronounced chemotherapeutic activity and minimal toxicity in preclinical studies. A phase I clinical trial to assess toxicity, the maximum tolerated dose (MTD) and pharmacokinetics in patients with advanced ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4334bcd535a823e07bde3586a3371e0b
https://pubmed.ncbi.nlm.nih.gov/9654110
https://pubmed.ncbi.nlm.nih.gov/9654110
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(5)
Limonene is a farnesyl transferase inhibitor that has shown antitumor properties. The drug had been given orally to cancer patients. Plasma and urine samples collected from the patients were examined by reversed-phase HPLC-atmospheric pressure chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98fdb643ac109962a047e67a98d9da84
https://pubmed.ncbi.nlm.nih.gov/8723738
https://pubmed.ncbi.nlm.nih.gov/8723738
Publikováno v:
Rapid communications in mass spectrometry : RCM. 10(10)
Liquid chromatography with an electrospray ionization (ESI) interface has been applied to study the anticancer drug taxol and its metabolites after incubation with human hepatic microsomes. The parent drug and its metabolites were monitored in the po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e962bc54c61828030fcac931e1f7a1f9
https://pubmed.ncbi.nlm.nih.gov/8759326
https://pubmed.ncbi.nlm.nih.gov/8759326