Výsledky vyhledávání - "G K Jacobsen"

A novel double staining strategy for improved detection of testicular carcinoma in situ cells in human semen samples

Autor: N E Skakkebaek, Kristian Almstrup, A. Jørgensen, Thomas Horn, Inge A. Olesen, H. Leffers, J E Nielsen, David Møbjerg Kristensen, E. Rajpert-De Meyts, G K Jacobsen

Publikováno v: Andrologia. 44:78-85

Prompted by the recently reported expression of POU5F1 (OCT3/4) in epididymis, a panel of markers for carcinoma in situ (CIS) testis and testicular germ cell tumours (TGCT), including AP-2γ(TFAP2C), NANOG, OCT3/4, KIT, placental-like alkaline phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3943a3f4324f2f3b2b67969cf6f6b434
https://doi.org/10.1111/j.1439-0272.2010.01108.x

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Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

Autor: Indira B. Taylor, Ruth M. S. Hansen, Andrew O.M. Wilkie, G K Jacobsen, Anne Goriely, Inge A. Olesen, Simon J. McGowan, Gilean McVean, Susanne P. Pfeifer, Ewa Rajpert-De Meyts

Publikováno v: Nature genetics

Genes mutated in congenital malformation syndromes are frequently implicated in oncogenesis, but the causative germline and somatic mutations occur in separate cells at different times of an organism's life. Here we unify these processes to a single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2047dca45fdd6cf985d86e4870cafd0c
https://doi.org/10.1038/ng.470

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Endoscopic ultrasound guided biopsy performed routinely in lung cancer staging spares futile thoracotomies: Preliminary results from a randomised clinical trial

Autor: Birgit Guldhammer Skov, Asger Dirksen, Mark Krasnik, Peter Vilmann, Ulrik Lassen, Paul Frost Clementsen, G. K. Jacobsen, Niels Maltbaek, Soeren S. Larsen

Publikováno v: Lung Cancer. 49:377-385

Summary Background: Up to 45% of operations with curative intent for non-small-cell lung cancer (NSCLC) can be regarded as futile, apparently because the stage of the disease is more advanced than expected preoperatively. During the past decade sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943756e314aca5300a5d92401265ba8f
https://doi.org/10.1016/j.lungcan.2005.04.005

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Endoscopic ultrasound guided biopsy versus mediastinoscopy for analysis of paratracheal and subcarinal lymph nodes in lung cancer staging

Autor: Mark Krasnik, Paul Frost Clementsen, Birgit Guldhammer Skov, Peter Vilmann, Soeren S. Larsen, Asger Dirksen, G. K. Jacobsen

Publikováno v: Lung Cancer. 48:85-92

Exact mediastinal evaluation of patients with non-small-cell lung cancer (NSCLC) is mandatory to improve selection of resectable and curable patients for surgery. Mediastinoscopy (MS) and endoscopic ultrasound guided fine needle aspiration biopsy (EU

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5ed5e7f085262d84f141432c0e600e
https://doi.org/10.1016/j.lungcan.2004.10.002

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The immunohistochemical expression pattern of Chk2, p53, p19INK4d , MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma

Autor: Florence Aubry, Jiri Bartek, Michel Samson, N E Skakkebaek, E. Rajpert-De Meyts, G K Jacobsen, J Bartkova

Publikováno v: Histopathology. 42:217-226

Aims: Spermatocytic seminoma is a rare germ cell derived tumour of the testis that occurs mainly in older men. We analysed the expression of recently discovered markers for germ cell differentiation and the mitosis–meiosis transition in order to de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e48e42f2d7dfb95edb41f033da322e3c
https://doi.org/10.1046/j.1365-2559.2003.01587.x

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The Cancer-Testis Gene, NY-ESO-1, Is Expressed in Normal Fetal and Adult Testes and in Spermatocytic Seminomas and Testicular Carcinoma In Situ

Autor: G K Jacobsen, Sébastien Henno, Ewa Rajpert-De Meyts, Nathalie Rioux-Leclercq, Bernard Jégou, Laurence Olivo, Anne-Pascale Satie, Giulio C. Spagnoli, Michel Samson

Publikováno v: Laboratory Investigation. 82:775-780

Cancer/testis genes are potential targets for therapeutic genetic and immunologic approaches, and are highly expressed in a large variety of human cancers. However, they are not expressed in normal tissues, with the exception of the testis. The NY-ES

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbbe2d2ba44760bf960c9c4442ba98b
https://doi.org/10.1097/01.lab.0000017169.26718.5f

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Endoscopic ultrasound guided biopsy of mediastinal lesions has a major impact on patient management

Autor: K Folke, Søren S. Larsen, Jesper Holst Pedersen, Mark Krasnik, P Faurschou, G. K. Jacobsen, Peter Vilmann

Publikováno v: Thorax. 57:98-103

Background: A study was undertaken to evaluate the clinical impact of endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNA) in patients with mediastinal masses suspected of malignancy. Methods: From April 1993 to December 1999, 84 pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5db5e92fd480b57c10d5ea440acebbf
https://doi.org/10.1136/thorax.57.2.98

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Experiência preliminar com um novo método de biópsia aspirativa guiada por ecografia endoscópica transbrônquica no diagnóstico de lesões mediastínicas e hilares

Autor: Mark Krasnik, G. K. Jacobsen, Peter Vilmann, Søren S. Larsen

Publikováno v: Revista Portuguesa de Pneumologia, Vol 10, Iss 2, Pp 173-175 (2004)

RESUMO: O correcto estadiamento do cancro do pulmão é fundamental, não só na determinação do prognóstico mas também na orientação terapêutica.A avaliação da extensão tumoral ao mediastino, por invasão directa ou metastática ganglionar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158c1f10b6f3aea153be79099d1ff3b7

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