Zobrazeno 1 - 10
of 17
pro vyhledávání: '"G Joseph Franklin"'
Autor:
Jason Deng, Svetlana Belyanskaya, Ninad Prabhu, Christopher Arico-Muendel, Hongfeng Deng, Christopher B. Phelps, David I. Israel, Hongfang Yang, Joseph Boyer, G. Joseph Franklin, Jeremy L. Yap, Kenneth E. Lind, Ching-Hsuan Tsai, Christine Donahue, Jennifer D. Summerfield
Publikováno v:
SLAS Discovery, Vol 29, Iss 5, Pp 100171- (2024)
DNA-encoded small molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, it has been used to identify ligands against targets that are soluble or overexpressed on cell surfaces. Here,
Externí odkaz:
https://doaj.org/article/200cb0758edc446ea0423cf022c88bf1
Autor:
Xiaopeng Bai, Eric X Shi, Kenneth E Lind, Lisa A Marcaurelle, Bing Xia, Vera Q. Bodmer, G Joseph Franklin, Cynthia H. Chiu, LaShadric C. Grady, Eleanor Watts, Jennifer Summerfield, Katie L Sargent Bedard, Xiaojie Lu, Bryan W. King
Publikováno v:
ACS Med Chem Lett
[Image: see text] DNA-encoded library (DEL) technology is a powerful platform for hit identification in academia and the pharmaceutical industry. When conducting off-DNA resynthesis hit confirmation after affinity selection, PCR/sequencing, and data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b32812ada9796c121b40217a07116b2
https://europepmc.org/articles/PMC8274064/
https://europepmc.org/articles/PMC8274064/
Autor:
Paolo A. Centrella, Peng Li, G Joseph Franklin, Svetlana L. Belyanskaya, Joseph P. Marino, Steven R. Skinner, Barry A. Morgan, Matthew A. Clark, Jason W. Dodson, Jeffrey A. Messer, Yun Ding, Jennifer L. DeLorey, David I. Israel
Publikováno v:
Bioorganicmedicinal chemistry. 41
Inhibition of soluble epoxide hydrolase (sEH) has recently emerged as a new approach to treat cardiovascular disease and respiratory disease. Inhibitors based on 1,3,5-triazine chemotype were discovered through affinity selection against two triazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ef26aa0ff6dd53c73f4758004748fd
https://pubmed.ncbi.nlm.nih.gov/34023664
https://pubmed.ncbi.nlm.nih.gov/34023664
Autor:
G. Joseph Franklin, David R. Lancia, Christopher S. Kollmann, Kelly A. McCarthy, Eneida Pardo, Jonathan C. O’Connell, Martin Olbrot
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(5)
DNA-encoded library (DEL) technology has become a prominent screening platform in drug discovery owing to the capacity to screen billions or trillions of compounds in a single experiment. Although numerous successes with DEL technology have been repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca5d3eb46e4e5dae3c2de3deba4fe6f
https://pubmed.ncbi.nlm.nih.gov/32107961
https://pubmed.ncbi.nlm.nih.gov/32107961
Autor:
Jin Li, Jinqiao Wan, G. Joseph Franklin, Jing Fan, Ting Peng, Jing Feng, Jonathan C. O’Connell, Liqiang Su, David R. Lancia, Guansai Liu
Publikováno v:
Organic letters. 22(4)
2-Aminobenzimidazole cores are among the most common structural components in medicinal chemistry and can be found in many biologically active molecules. Herein, we report a mild protocol for the synthesis of multifunctional 2-aminobenzimidazoles on-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7eb65b74fba6f5d4311774f5000b9c
https://pubmed.ncbi.nlm.nih.gov/31999466
https://pubmed.ncbi.nlm.nih.gov/31999466
Autor:
McCarthy, Kelly A., G. Joseph Franklin, Lancia, David R., Olbrot, Martin, Pardo, Eneida, O’Connell, Jonathan C., Kollmann, Christopher S.
Supplemental material, Supplemental_Material_McCarthy_et_al for The Impact of Variable Selection Coverage on Detection of Ligands from a DNA-Encoded Library Screen by Kelly A. McCarthy, G. Joseph Franklin, David R. Lancia, Martin Olbrot, Eneida Pardo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faa41965a8753790a96cfddff341223
Autor:
Patricia A. Elkins, Steven R. Skinner, G Joseph Franklin, Nicholas D. Adams, Joelle Lorraine Burgess, Michael D. Schaber, Kenneth E Lind, Kaushik Raha, Ghotas Evindar, Yun Ding, Hongfang Yang, Paolo A. Centrella, Ruth Lehr, Steven D. Knight, Jennifer L. DeLorey, Kurt R. Auger, Sibongile Mataruse, John W. Cuozzo, Patricia F Medeiros, Schmidt Stanley J, Matthew A. Clark
Publikováno v:
ACS Medicinal Chemistry Letters. 6:531-536
In the search of PI3K p110α wild type and H1047R mutant selective small molecule leads, an encoded library technology (ELT) campaign against the desired target proteins was performed which led to the discovery of a selective chemotype for PI3K isofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccf4a5855cf8c7c27a930644397fe22
https://doi.org/10.1021/acsmedchemlett.5b00025
https://doi.org/10.1021/acsmedchemlett.5b00025
Autor:
Matthew A. Clark, Svetlana L. Belyanskaya, Steven R. Skinner, Paolo A. Centrella, G Joseph Franklin, Sibongile Mataruse, Yun Ding, Jennifer L. DeLorey
Publikováno v:
ACS combinatorial science. 18(10)
DNA-encoded library technology (ELT) is a powerful tool for the discovery of new small-molecule ligands to various protein targets. Here we report the design and synthesis of biaryl DNA-encoded libraries based on the scaffold of 5-formyl 3-iodobenzoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f4d70299cbdcc415513e20f003c442
https://pubmed.ncbi.nlm.nih.gov/27571034
https://pubmed.ncbi.nlm.nih.gov/27571034
Autor:
Malcolm L. Gefter, Alexander L. Satz, Matthew C Oliff, Cecil E Rise, Sibongile Mataruse, Fan Li, Cynthia H. Chiu, John W. Cuozzo, Steven R. Skinner, Matthew A. Clark, Gang Yao, Kurt D Franzen, Paul Myers, Heather O’Keefe, Lujia Tang, Christopher S. Kollmann, Christopher P. Davie, Nils Jakob Vest Hansen, Neil R Carlson, Paolo A. Centrella, Michael Kelley, Patricia F Medeiros, Steven P Hale, Richard W. Wagner, Christopher C. Arico-Muendel, Dennis Benjamin, David I. Israel, Kurt van Vloten, G Joseph Franklin, Svetlana L. Belyanskaya, Jennifer L Svendsen, Kenneth E Lind, Raksha A. Acharya, Barry A. Morgan, Baoguang Zhao, Steffen Phillip Creaser, Malcolm J. Kavarana, Jinwei Jiang, Jeffrey A. Messer, Yun Ding
Publikováno v:
Nature Chemical Biology. 5:647-654
Biochemical combinatorial techniques such as phage display, RNA display and oligonucleotide aptamers have proven to be reliable methods for generation of ligands to protein targets. Adapting these techniques to small synthetic molecules has been a lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2643c1a620295ac72e51e7c637cb05cc
https://doi.org/10.1038/nchembio.211
https://doi.org/10.1038/nchembio.211
Autor:
Zining Wu, Sibongile Mataruse, Alex M. Tamburino, Gang Yao, Jeffrey A. Messer, Yun Ding, Jean Zhang, G Joseph Franklin, Jianghe Deng, Todd L. Graybill, Xin Zeng, David D. Wisnoski, Frank T. Coppo, David I. Israel, Genaro S. Scavello, Jennifer Summerfield, Andrew J. Pope, Michael Platchek, Vera Q. Bodmer, Paolo A. Centrella, Jing Chai, Katie L Sargent Bedard
Publikováno v:
ACS combinatorial science. 17(12)
DNA-encoded small-molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, this technology has been used with soluble protein targets that are produced and used in a purified state. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662cc2aa88e33f6c57ffd2c4564e3e69
https://pubmed.ncbi.nlm.nih.gov/26562224
https://pubmed.ncbi.nlm.nih.gov/26562224