SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor.

Autor: Marco A R Vinolo, G John Ferguson, Suhasini Kulkarni, George Damoulakis, Karen Anderson, Mohammad Bohlooly-Y, Len Stephens, Phillip T Hawkins, Rui Curi

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e21205 (2011)

Short chain fatty acids (SCFAs) have recently attracted attention as potential mediators of the effects of gut microbiota on intestinal inflammation. Some of these effects have been suggested to occur through the direct actions of SCFAs on the GPR43

Externí odkaz: https://doaj.org/article/b81bd6ce141845e09edfc122af8ac149

Adverse immunological responses against non-viral nanoparticle (NP) delivery systems in the lung

Autor: Jeremy P. Derrick, G John Ferguson, José Luís Guedes dos Santos, Leonor de Braganca

Publikováno v: Journal of Immunotoxicology
article-version (VoR) Version of Record
Journal of Immunotoxicology, Vol 18, Iss 1, Pp 61-73 (2021)

There is a large, unmet medical need to treat chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis and other respiratory diseases. New modalities are being developed, including gene therapy which treats the disease at the DNA/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462f927e344dc0d37714e1e3727bb485
https://doi.org/10.1080/1547691x.2021.1902432

Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach

Autor: Hervé Guillou, Charlotte Lécureuil, Karen E. Anderson, Sabine Suire, G. John Ferguson, Chris D. Ellson, Alexander Gray, Nullin Divecha, Phillip T. Hawkins, Len R. Stephens

Publikováno v: Journal of Lipid Research, Vol 48, Iss 3, Pp 726-732 (2007)

We describe a novel approach to the relative quantification of phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] and its application to measure, in neutrophils, the activation of phosphoinositide 3-kinase (PI3K). This protein-lipid overlay

Externí odkaz: https://doaj.org/article/2b2c2d886e3941b18e8415ca8495f34b

Localizing the lipid products of PI3Kγ in neutrophils

Autor: Arnaud Deladeriere, Hervé Guillou, Sabine Suire, Oliver Rausch, G. John Ferguson, Simon Andrews, Simon Walker, Tamara Chessa, Till Bretschneider, Cheng-Jin Du, Laura J. Norton, Anne Segonds-Pichon, Len R. Stephens, Takehiko Sasaki, Peter Finan, Yvonne E. Lindsay, Phillip T. Hawkins, John M. Lucocq

Publikováno v: Advances in Biological Regulation
Advances in Biological Regulation, 2016, 60, pp.36-45. ⟨10.1016/j.jbior.2015.10.005⟩
Advances in Biological Regulation (60), 36-45. (2016)

Class I phosphoinositide 3-kinases (PI3Ks) are important regulators of neutrophil migration in response to a range of chemoattractants. Their primary lipid products PtdIns(3,4,5)P3 and PtdIns(3,4)P2 preferentially accumulate near to the leading edge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ebb156550e35ea5bae9fafd142bb50

IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD

Autor: Katherine Stephenson, Michiko Mori, Sanjay Sethi, Christine K. Ward, Jonas S. Erjefält, Natasha A. Karp, Gautam Damera, Donna K. Finch, Emmanuel Briend, G. John Ferguson, Matthew A. Sleeman

Publikováno v: Respiratory Research

Background Increased interferon gamma (IFNγ) release occurs in Chronic Obstructive Pulmonary Disease (COPD) lungs. IFNγ supports optimal viral clearance, but if dysregulated could increase lung tissue destruction. Methods The present study investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699e845eb61d284adf3a9d0154da472a
https://doi.org/10.1186/s12931-017-0641-7