Výsledky vyhledávání - "G Jean, Horbach"

Akademický článek

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

Autor: Patrick J. Engelberts, Ida H. Hiemstra, Bart de Jong, Danita H. Schuurhuis, Joyce Meesters, Irati Beltran Hernandez, Simone C. Oostindie, Joost Neijssen, Edward N. van den Brink, G. Jean Horbach, Sandra Verploegen, Aran F. Labrijn, Theodora Salcedo, Janine Schuurman, Paul W.H.I Parren, Esther C.W. Breij

Publikováno v: EBioMedicine, Vol 52, Iss , Pp - (2020)

Background: DuoBody®-CD3xCD20 (GEN3013) is a full-length human IgG1 bispecific antibody (bsAb) recognizing CD3 and CD20, generated by controlled Fab-arm exchange. Its Fc domain was silenced by introduction of mutations L234F L235E D265A. Methods: T-

Externí odkaz: https://doaj.org/article/8eed60dbcc62461eb9d7224a1bb469dc

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DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

Autor: Aran F. Labrijn, Paul W. H. I. Parren, Bart de Jong, G. Jean Horbach, Patrick J. Engelberts, Ida H. Hiemstra, Irati Beltran Hernandez, Joost J. Neijssen, Joyce I. Meesters, Esther C.W. Breij, Danita H. Schuurhuis, Sandra Verploegen, Edward Van Den Brink, Janine Schuurman, Theodora Salcedo, Simone C. Oostindie

Publikováno v: EBioMedicine
EBioMedicine, 52. ELSEVIER
EBioMedicine, Vol 52, Iss, Pp-(2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccb636abb875c0b73a9ac71d9242a0c
https://pubmed.ncbi.nlm.nih.gov/31981978

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Cytotoxic effects of 109 reference compounds on rat H4IIE and human HepG2 hepatocytes. III: Mechanistic assays on oxygen consumption with MitoXpress and NAD(P)H production with Alamar Blue™

Autor: G. Jean Horbach, Walter M.A. Westerink, Joe C.R. Stevenson, Willem G.E.J. Schoonen

Publikováno v: Toxicology in Vitro. 26:511-525

In vitro toxicity screening can reduce the attrition rate of drug candidates in the pharmaceutical industry in the early development process. The focus in this study is to compare the sensitivity for cytotoxicity of a time-resolved fluoro metric oxyg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a729f753a23cb2d518ec01ccd7abd4
https://doi.org/10.1016/j.tiv.2012.01.004

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Evaluation of research activities and research needs to increase the impact and applicability of alternative testing strategies in risk assessment practice

Autor: Marie-Jeanne W. A. Schiffelers, G. Jean Horbach, Ivonne M.C.M. Rietjens, Geny M. M. Groothuis, Ans Punt, Bas J. Blaauboer, Johannes J.M. van de Sandt

Publikováno v: Regulatory toxicology and pharmacology, 61(1), 105-114. ACADEMIC PRESS INC ELSEVIER SCIENCE
Regulatory Toxicology and Pharmacology 61 (2011) 1
Regulatory Toxicology and Pharmacology, 1, 61, 105-114
Regulatory Toxicology and Pharmacology, 61(1), 105-114

The present paper aims at identifying strategies to increase the impact and applicability of alternative testing strategies in risk assessment. To this end, a quantitative and qualitative literature evaluation was performed on (a) current research ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5caa504caa15740a099f876dc1adc2cf
https://hdl.handle.net/11370/3a0107fc-f178-4756-84a3-e8f8c50a9bba

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The development of RAD51C, Cystatin A, p53 and Nrf2 luciferase-reporter assays in metabolically competent HepG2 cells for the assessment of mechanism-based genotoxicity and of oxidative stress in the early research phase of drug development

Autor: Joe C.R. Stevenson, G. Jean Horbach, Willem G.E.J. Schoonen, Walter M. A. Westerink

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 696:21-40

Four different mechanism-based high-throughput luciferase-reporter assays were developed in human HepG2 cells, which contain phase I and II metabolic activity and a functionally active p53 protein. The promoter regions of RAD51C and Cystatin A, as we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dee5d2395b38c84d829d91cd2af21a9
https://doi.org/10.1016/j.mrgentox.2009.12.007

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Sensitivity of 1H NMR Analysis of Rat Urine in Relation to Toxicometabonomics. Part I: Dose-Dependent Toxic Effects of Bromobenzene and Paracetamol

Autor: Carol Thijssen-van Zuylen, Willem G.E.J. Schoonen, Pieter Zandberg, Martin J. Smit, G. Jean Horbach, Joop H. J. van Nesselrooij, Jan-Remt Mellema, Jack T. W. E. Vogels, Albert C. Tas, Jan-Peter H. T. M. Ploemen, Cathelijne P. A. M. Kloks

Publikováno v: Toxicological Sciences. 98:271-285

1H nuclear magnetic resonance (NMR) spectroscopy of rat urine in combination with pattern recognition analysis was evaluated for early noninvasive detection of toxicity of investigational chemical entities. Bromobenzene (B) and paracetamol (P) were a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfc337fbdadb07e10ff359f447d8713
https://doi.org/10.1093/toxsci/kfm076

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A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response

Autor: Jan Polman, Willem G.E.J. Schoonen, Harry Vrieling, Micheline Giphart-Gassler, Jacqueline J.C.M. Kruse, J. Peter Svensson, Bob van de Water, G. Jean Horbach, Merei Huigsloot

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 617:58-70

Accumulation of damage in undifferentiated cells may threaten homeostasis and regenerative capacity. Remarkably, p53 has been suggested to be transcriptionally inactive in these cells. To gain insight in the kinetics and interplay of the predominant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59342bd0a71b1bb96e2419cb34306cc7
https://doi.org/10.1016/j.mrfmmm.2006.12.004

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High-throughput screening for analysis of in vitro toxicity

Autor: Willem G E J, Schoonen, Walter M A, Westerink, G Jean, Horbach

Publikováno v: EXS. 99

The influence of combinatorial chemistry and high-throughput screening (HTS) technologies in the pharmaceutical industry during the last 10 years has been enormous. However, the attrition rate of drugs in the clinic due to toxicity during this period

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4381cad1d41c913d632d2d7cb83422da
https://pubmed.ncbi.nlm.nih.gov/19157069

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