Zobrazeno 1 - 10
of 14
pro vyhledávání: '"G J Smits"'
Autor:
G M R, DE Luca, E, Desclos, R M P, Breedijk, L, Dolz-Edo, G J, Smits, L, Nahidiazar, P, Bielefeld, L, Picavet, C P, Fitzsimons, R, Hoebe, E M M, Manders
Publikováno v:
Journal of microscopy. 266(2)
The new high-sensitive and high-resolution technique, Re-scan Confocal Microscopy (RCM), is based on a standard confocal microscope extended with a re-scan detection unit. The re-scan unit includes a pair of re-scanning mirrors that project the emiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1e87817aea0670304185465f860ef33
https://pubmed.ncbi.nlm.nih.gov/28257147
https://pubmed.ncbi.nlm.nih.gov/28257147
Publikováno v:
European Journal of Medicinal Chemistry. 25:589-594
Semi-peptidic analogues of the angiotensin II (AII) antagonist [Ile8] AII have been prepared by the solid phase method and, for some steps, by synthesis in solution. In the modified analogues 4–15, the N-terminal di- or tripeptidic fragments (Asp-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2677c62c224a1cf218e4597479b3ef0e
https://doi.org/10.1016/0223-5234(90)90183-4
https://doi.org/10.1016/0223-5234(90)90183-4
Autor:
Maria A. Palomo, Gillian M. Olins, G J Smits, K S Salles, Joan M. O'Neal, P R Bovy, Dennis R. Patton, A. J. Trapani, J P Koepke, Ellen G. Mcmahon
Publikováno v:
Journal of Medicinal Chemistry. 33:1477-1482
A series of analogues of the recently reported angiotensin II (AII) antagonist [Sar1]AII-(1-7)-amide or des-Phe8[Sar1]AII (3) have been prepared by solid-phase synthesis and purified by reverse-phase liquid chromatography. The agonist and antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1df0bc239548aec2e50ed2041de3888
https://doi.org/10.1021/jm00167a030
https://doi.org/10.1021/jm00167a030
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 286(2)
This study examined the cardioprotective effects and pharmacology of the novel adenosine A1/A2 receptor agonist ([1S-[1a,2b,3b, 4a(S*)]]-4-[7-[[2-(3-chloro-2-thienyl)-1-methylpropyl]amino]-3H-imida zo[4,5-b] pyridyl-3-yl] cyclopentane carboxamide) (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16d2395ba048bd720692807245935cf0
https://pubmed.ncbi.nlm.nih.gov/9694911
https://pubmed.ncbi.nlm.nih.gov/9694911
Autor:
B F, Cox, G J, Smits
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(3)
ATP produces significant cardiovascular effects by activation of P2 purinoceptors. In the present study, we examined the regional hemodynamic profiles produced by intravenous administration of a P2X and a P2Y purinergic receptor agonist. Sprague-Dawl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d94abec70395cfdb0f38be184f0ba68
https://pubmed.ncbi.nlm.nih.gov/8667215
https://pubmed.ncbi.nlm.nih.gov/8667215
Publikováno v:
Yeast (Chichester, England). 12(5)
Glucose uptake in Saccharomyces cerevisiae is believed to consist of two kinetically distinguishable components, the affinity of which is modulated during growth on glucose. It has been reported that triple hexose-kinase deletion mutants do not exhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b03783cc87ba55ca1e1ca75140c8ffa5
https://pubmed.ncbi.nlm.nih.gov/8740417
https://pubmed.ncbi.nlm.nih.gov/8740417
Autor:
G M, Olins, V M, Corpus, S T, Chen, E G, McMahon, M A, Palomo, D E, McGraw, G J, Smits, C L, Null, M A, Brown, S E, Bittner
Publikováno v:
Journal of cardiovascular pharmacology. 22(4)
We describe the pharmacologic properties of SC-52458, 5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(1H-tetrazol - 5-ylphenyl)]pyridine, a novel nonpeptide angiotensin II (AII) receptor antagonist. SC-52458 was a potent inhibitor of [125I]AII bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78e2c546208b61b640c1a4c508ef0293
https://pubmed.ncbi.nlm.nih.gov/7505365
https://pubmed.ncbi.nlm.nih.gov/7505365
Autor:
Horng-Chih Huang, Gillian M. Olins, V. M. Corpus, Timothy S. Chamberlain, Ellen G. Mcmahon, David B. Reitz, J P Koepke, D. E. Mcgraw, Maria A. Palomo, G J Smits
Publikováno v:
Journal of medicinal chemistry. 36(15)
2,5-Dibutyl-2,4-dihydro-4-[[2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4' - yl]methyl]-3H-1,2,4-triazol-3-one, SC-51316, was synthesized as a potent and orally active angiotensin II (AII) receptor antagonist with a long duration of action. To explore the li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1e1f21326563e9abbedb66e83baca2
https://pubmed.ncbi.nlm.nih.gov/8340920
https://pubmed.ncbi.nlm.nih.gov/8340920
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 265(2)
In this report, we demonstrate that the adenosine agonist N-5'-ethyl-N6-(cyclopentyl) adenosine-5'-uronamide (RG14202) is a vasorelaxant in porcine coronary arterial rings (EC50 = 0.37 +/- 0.054 microM; n = 19). This vasorelaxation (VR) occurs despit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb403998fc444e72806a82f4efe6db1a
https://pubmed.ncbi.nlm.nih.gov/8496817
https://pubmed.ncbi.nlm.nih.gov/8496817
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 258(1)
The present investigation was undertaken to define the hemodynamic mechanisms by which the selective cyclic GMP phosphodiesterase inhibitor zaprinast (MB 22,948; 2-o-propoxy-phenyl-8-azapurin-6-one) lowers mean arterial pressure (MAP). Anesthetized r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b2a84a2ca473d9fd7c1606bac7aa557
https://pubmed.ncbi.nlm.nih.gov/1649294
https://pubmed.ncbi.nlm.nih.gov/1649294