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Intrathecal administration of liposomal neostigmine prolongs analgesia in mice

Autor: G J, Grant, B, Piskoun, M, Bansinath

Publikováno v: Acta anaesthesiologica Scandinavica. 46(1)

There is substantial evidence that cholinomimetic drugs increase pain threshold. However, the profound side effects of these agents have limited their clinical use either as analgesics or as analgesic adjuncts. A delivery system that would assure a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fc55bd8147c8625a3a96e71ddfd43eb
https://pubmed.ncbi.nlm.nih.gov/11903079

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Perineural antinociceptive effect of opioids in a rat model

Autor: G J, Grant, K, Vermeulen, M I, Zakowski, L, Langerman

Publikováno v: Acta anaesthesiologica Scandinavica. 45(7)

The research on conductive analgesia induced by perineural opioids generated a large body of conflicting data. In this study we reassessed the antinociceptive response to perineural administration of morphine, fentanyl or meperidine in a rat model.An

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f33dea88d471db6cd56bf2b7b6ea189
https://pubmed.ncbi.nlm.nih.gov/11472295

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DRV liposomal bupivacaine: preparation, characterization, and in vivo evaluation in mice

Autor: G J, Grant, Y, Barenholz, B, Piskoun, M, Bansinath, H, Turndorf, E M, Bolotin

Publikováno v: Pharmaceutical research. 18(3)

To evaluate the dehydration-rehydration technique to prepare a formulation of liposomal bupivacaine, and to assess its analgesic efficacy.Bupivacaine hydrochloride (BUP) was encapsulated into dehydration-rehydration vesicles (DRV) of varying phosphol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9939b26a7520e14f6c17044cbfc274fb
https://pubmed.ncbi.nlm.nih.gov/11442274

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Prolonged analgesia with liposomal bupivacaine in a mouse model

Autor: G J, Grant, K, Vermeulen, L, Langerman, M, Zakowski, H, Turndorf

Publikováno v: Regional anesthesia. 19(4)

Currently available local anesthetics have relatively limited duration of action and some may cause severe systemic toxicity. An ultralong lasting local anesthetic would be useful to produce prolonged intraoperative anesthesia and extended postoperat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::155df90b208756076bbeabc4b411935a
https://pubmed.ncbi.nlm.nih.gov/7947427

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