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Improving the Effectiveness of Isinglass Finings for Beer Clarification by Optimisation of the Mixing Process. Part 3: Full-Size Prototype Evaluation

Autor: A. J. Skipper, G. J. Freeman, C. T. Evans, J. M. Baron, M. K. Dawson, X. Le Gourrierec, M. H. B. Powell-Evans, C. A. Boulton, A. Patel, C. M. Grimmett

Publikováno v: Journal of the Institute of Brewing. 109:326-331

Previous work has identified the optimal two-stage static mixing process for a small-scale pilot rig. Protocols for scale-up to any brewery process line have been specified. A full-size prototype has been installed in a cask ale brewery. In most case

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87fae68e703da2c9869ea5fd1b913da5
https://doi.org/10.1002/j.2050-0416.2003.tb00605.x

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Improving the Effectiveness of Isinglass Finings for Beer Clarification by Optimisation of the Mixing Process. Part 2: Pilot Scale Experiments

Autor: C. M. Grimmett, C. T. Evans, M. K. Dawson, A. Patel, J. M. Baron, X. Le Gourrierec, C. A. Boulton, M. H. B. Powell-Evans, A. J. Skipper, G. J. Freeman

Publikováno v: Journal of the Institute of Brewing. 109:318-325

In order to optimise the process of fining beer there is a need to model the process in terms of addition, mixing and flocculation. Mixing of beer and finings has been achieved in a small laboratory stirred vessel that enables exact characterisation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0ba026983fd94d165bffcf7e22f6540
https://doi.org/10.1002/j.2050-0416.2003.tb00604.x

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Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4

Autor: P Höllsberg, C Scholz, D E Anderson, E A Greenfield, V K Kuchroo, G J Freeman, D A Hafler

Publikováno v: The Journal of Immunology. 159:4799-4805

CD80 (B7-1) and CD86 (B7-2) on APC provide a major costimulatory signal through interactions with CD28 on T cells. Absent from resting human T cells, CD86 is up-regulated early upon T cell activation, whereas CD80 expression appears later. Whereas T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::325d3a410b408b8ad7dc8a8fc1e34dd5
https://doi.org/10.4049/jimmunol.159.10.4799

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CD101 is expressed by skin dendritic cells Role in T-lymphocyte activation Role in T-lymphocyte activation

Autor: Janine Wechsler, Laurence Boumsell, Dominique Charue, G. J. Freeman, Martine Bagot, Isabelle Martinel, Marie-Laure Boulland, Armand Bensussan, F. Weill

Publikováno v: Tissue Antigens. 50:439-448

CD101 was first described in our laboratory using two different monoclonal antibodies, BA27 and BB27, recognizing a 140-kDa disulfide-bonded homodimeric polypeptide on a small subset of circulating T lymphocytes and on most activated T cells in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65d9b24aab0fbb8760c9ece9ae41c8e2
https://doi.org/10.1111/j.1399-0039.1997.tb02898.x

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Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death

Autor: V A Boussiotis, B J Lee, G J Freeman, J G Gribben, L M Nadler

Publikováno v: The Journal of Immunology. 159:3156-3167

Since TCR-mediated stimulation induces T cells to become sensitive to Fas-mediated activation-induced cell death (Fas-AICD), we examined whether anergized and CD28-costimulated T cell clones were equally sensitive to Fas-AICD. Here, we show that TCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54ec4770e293ad9b4f39be856d3c466a
https://doi.org/10.4049/jimmunol.159.7.3156

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Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones

Autor: D E Anderson, L J Ausubel, J Krieger, P Höllsberg, G J Freeman, D A Hafler

Publikováno v: The Journal of Immunology. 159:1669-1675

The influence of costimulation on the T cell response to altered peptide ligands that act as either partial or weak agonists for human CD4+ T cell clones was examined. Using stable Chinese hamster ovary (CHO) cell transfectants expressing DR2 (DRB1*1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e82bff10e67d6d80476a00c44cc8ce8d
https://doi.org/10.4049/jimmunol.159.4.1669

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B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors

Autor: E A Greenfield, E Howard, T Paradis, K Nguyen, F Benazzo, P McLean, P Höllsberg, G Davis, D A Hafler, A H Sharpe, G J Freeman, V K Kuchroo

Publikováno v: The Journal of Immunology. 158:2025-2034

The B7 family of costimulatory molecules provides the second signal necessary for activation of T cells. In the absence of the second signal, responding T cells become anergic. Although predominantly expressed on professional APCs, recent evidence sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a5aeb739c656cf80df6f4e03683c031
https://doi.org/10.4049/jimmunol.158.5.2025

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Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation

Autor: C Scholz, G J Freeman, E A Greenfield, D A Hafler, P Höllsberg

Publikováno v: The Journal of Immunology. 157:2932-2938

Two distinct signals are required to activate T cells: an Ag-specific signal and a costimulatory signal mediated primarily by B7-1 (CD80) and B7-2 (CD86) through interactions with CD28. Costimulation appears to be critical in regulating autoreactive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::413c6a6e04e3b1646340eea2e05e5145
https://doi.org/10.4049/jimmunol.157.7.2932

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