Zobrazeno 1 - 8
of 8
pro vyhledávání: '"G J A, Ramakers"'
Autor:
Mara Dierssen, G. J. A. Ramakers
Publikováno v:
Genes, Brain and Behavior. 5:48-60
Mental retardation (MR) is a developmental brain disorder characterized by impaired cognitive performance and adaptive skills that affects 1-2% of the population. During the last decade, a large number of genes have been cloned that cause MR upon mut
Autor:
Tjitske Kleefstra, H Van Bokhoven, B.C.J. Hamel, Helger G. Yntema, G J A Ramakers, C E Franken, Erik A. Sistermans, Y H J M Arens, C F C H Hulsmans, W. N. Nillesen, B. B. A. de Vries
Publikováno v:
Clinical Genetics. 66:318-326
Recently, the polyglutamine-binding protein 1 (PQBP1) gene was found to be mutated in five of 29 families studied with X-linked mental retardation (XLMR) linked to Xp. The reported mutations include duplications or deletions of AG dinucleotides in th
Autor:
M. Martinez de Lagran, Mara Dierssen, Javier DeFelipe, M. Morales, Ruth Benavides-Piccione, Inmaculada Ballesteros-Yáñez, Cristina Fillat, G. J. A. Ramakers, M.M. Calvo
Publikováno v:
Cerebral Cortex, 22, 2867-2877. Oxford University Press
Cerebral Cortex, ISSN 1047-3211, 2012-12, Vol. 22, No. 12
Archivo Digital UPM
instname
Cerebral Cortex, ISSN 1047-3211, 2012-12, Vol. 22, No. 12
Archivo Digital UPM
instname
Down syndrome (DS) is the most frequent genetic cause of mental retardation. Cognitive dysfunction in these patients is correlated with reduced dendritic branching and complexity, along with fewer spines of abnormal shape that characterize the cortic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b961421a5be8d41bcb4b2ca8756e3c
https://pure.knaw.nl/portal/en/publications/a245f31a-f1d4-482a-b15e-6f8932999268
https://pure.knaw.nl/portal/en/publications/a245f31a-f1d4-482a-b15e-6f8932999268
Publikováno v:
Brain Research Bulletin. 26:429-432
We have used the GABA-A antagonist picrotoxin (PTX) to investigate whether chronic disinhibition, leading to intensified neuronal firing, would induce a specific pattern of physiological alterations in cultured rat neocortex cells. Overall mean spont
Autor:
G. J. A. Ramakers, G. J. Boer
Publikováno v:
European Journal of Neuroscience. 3:154-161
Chronic suppression of spontaneously occurring bioelectric activity (BEA) has been shown to increase neuronal cell death in tissue culture, but may also affect astrocytes. We investigated this process in primary cultures of rat cerebral cortex by mea
Autor:
T, Kleefstra, C E, Franken, Y H J M, Arens, G J A, Ramakers, H G, Yntema, E A, Sistermans, C F C H, Hulsmans, W N, Nillesen, H, van Bokhoven, B B A, de Vries, B C J, Hamel
Publikováno v:
Clinical genetics. 66(4)
Recently, the polyglutamine-binding protein 1 (PQBP1) gene was found to be mutated in five of 29 families studied with X-linked mental retardation (XLMR) linked to Xp. The reported mutations include duplications or deletions of AG dinucleotides in th
Autor:
M. A. Corner, G. J. A. Ramakers
Publikováno v:
Physiology, Pharmacology and Development of Epileptogenic Phenomena ISBN: 9783642467349
Physiology, Pharmacology and Development of Epileptogenic Phenomena
Physiology, Pharmacology and Development of Epileptogenic Phenomena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33cdb49246266c51b9f163626c24753e
https://doi.org/10.1007/978-3-642-46732-5_40
https://doi.org/10.1007/978-3-642-46732-5_40
Publikováno v:
Experimental Brain Research. 79
Quantitative analysis of neuronal firing patterns was used to study the effects of chronic suppression of bioelectric activity (BEA) on functional development in primary cultures of fetal rat cerebral cortex. BEA was monitored with extracellular elec