Výsledky vyhledávání - "G J, Zingaro"

Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates

Autor: W T, Ashton, S M, Hutchins, W J, Greenlee, G A, Doss, R S, Chang, V J, Lotti, K A, Faust, T B, Chen, G J, Zingaro, S D, Kivlighn

Publikováno v: Journal of Medicinal Chemistry. 36:3595-3605

Two series of potential angiotensin II antagonists derived from carboxyl-functionalized "diazole" heterocycles have been prepared and evaluated. Initially, a limited investigation of 4-arylimidazole-5-carboxylates led to 2-n-butyl-4-(2-chlorophenyl)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753bfdfbaa35b0d4d38b18fe302a41b2
https://doi.org/10.1021/jm00075a014

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In vivo pharmacology of an angiotensin AT1 receptor antagonist with balanced affinity for AT2 receptors

Autor: S D, Kivlighn, G J, Zingaro, R A, Gabel, T P, Broten, R S, Chang, D L, Ondeyka, N B, Mantlo, R E, Gibson, W J, Greenlee, P K, Siegl

Publikováno v: European journal of pharmacology. 294(2-3)

L-163,017 (6-[benzoylamino]-7-methyl-2-propyl-3-[[2'-(N-(3-methyl-1-butoxy) carbonylaminosulfonyl)[1,1']-biphenyl-4-yl]methyl]-3H-imidazo[4,5- b]pyridine) is a potent, orally active, nonpeptide angiotensin II receptor antagonist. Conscious rats and d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d16928c441f18f934b78399b01fee485
https://pubmed.ncbi.nlm.nih.gov/8750704

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Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist

Autor: D L, Williams, K L, Murphy, N A, Nolan, J A, O'Brien, D J, Pettibone, S D, Kivlighn, S M, Krause, E V, Lis, G J, Zingaro, R A, Gabel

Publikováno v: The Journal of pharmacology and experimental therapeutics. 275(3)

L-754,142, (-)-N-(4-iso-propylbenzenesulfonyl)-alpha-(4-carboxyl-2-n-propy lphenoxy)-3,4- methylenedioxyphenylacetamide, is a potent nonpeptidyl endothelin antagonist (e.g., Ki: cloned human ETA = 0.062 nM: cloned human ETB = 2.25 nM), with high spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a08f6f0ed94740a6d3d6271094bc219
https://pubmed.ncbi.nlm.nih.gov/8531124

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Discovery of L-162,313: a nonpeptide that mimics the biological actions of angiotensin II

Autor: S. D. Kivlighn, W. R. Huckle, G. J. Zingaro, R. A. Rivero, V. J. Lotti, R. S. Chang, T. W. Schorn, N. Kevin, R. G. Johnson, W. J. Greenlee, al. et

Publikováno v: The American journal of physiology. 268(3 Pt 2)

L-162,313 (5,7-dimethyl-2-ethyl-3-[[4-[2(n- butyloxycarbonylsulfonamido)-5-isobutyl-3-thienyl]phenyl]methyl]- imadazo[4,5-b]pyridine) is a nonpeptide that mimics the biological actions of angiotensin II (ANG II). The intravenous administration of L-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea11ce1910b36d980834ad4c9dba0575
https://pubmed.ncbi.nlm.nih.gov/7900925

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In vivo pharmacology of a novel AT1 selective angiotensin II receptor antagonist, MK-996

Autor: S D, Kivlighn, G J, Zingaro, R A, Gabel, T P, Broten, T W, Schorn, L W, Schaffer, E M, Naylor, P K, Chakravarty, A A, Patchett, W J, Greenlee

Publikováno v: American journal of hypertension. 8(1)

MK-996, N-(4'-(5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridin-3-yl- methyl)1,1'-biphenyl-2-yl)-sulfonylbenzamide, is a potent, orally active, highly selective, nonpeptide angiotensin II (AII) receptor antagonist. MK-996 prevents the pressor response t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33e040612e1cf4b0b8341dac48e41422
https://pubmed.ncbi.nlm.nih.gov/7734099

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