Zobrazeno 1 - 10
of 37
pro vyhledávání: '"G J, Pepe"'
Autor:
G. J. Pepe
Publikováno v:
Endocrine Reviews. 16:608-648
Publikováno v:
Biology of reproduction. 65(4)
The present study was conducted to determine the developmental expression of placental insulin-like growth factor (IGF)-II, IGF-binding protein (IGFBP)-1 and -2, and IGF-II receptor mRNA expression during baboon pregnancy and whether estrogen, the le
Publikováno v:
Endocrinology. 142(1)
We previously showed that the messenger RNA and protein levels of the 11ss-hydroxysteroid dehydrogenase (11betaHSD) enzymes catalyzing glucocorticoid reduction (11betaHSD-1) and oxidation (11betaHSD-2) increased with advancing baboon gestation and co
Publikováno v:
Endocrinology. 140(12)
We have previously shown that estrogen regulates the development and function of the fetal and definitive/transitional zones of the primate fetal adrenal gland. Thus, during baboon pregnancy estrogen acts directly on the fetal zone to suppress ACTH-s
Autor:
G J, Pepe, E D, Albrecht
Publikováno v:
Steroids. 64(9)
By using the baboon as an in vivo model for the study of the endocrinology of human pregnancy, studies in the authors' laboratories have shown that the primate placenta is an estrogen target tissue and that estrogen, via interaction with the estrogen
Publikováno v:
Biology of reproduction. 61(1)
We have shown that ACTH receptor mRNA expression and steroidogenesis were increased in the transitional zone and decreased in the fetal zone of the baboon fetal adrenal in the second half of gestation. Thus, we proposed that there is a divergence in
Publikováno v:
The Journal of clinical endocrinology and metabolism. 83(8)
Although the human placenta at term exhibits high levels of phospholipase A2 (PLA2) enzyme activity, our understanding of the ontogenesis, regulation, and specific roles of placental phospholipases A2 remains relatively incomplete. Using the baboon a
Publikováno v:
The Journal of clinical endocrinology and metabolism. 83(3)
Although fetal pituitary ACTH is important to fetal adrenal growth and steroidogenesis in the second half of primate pregnancy, its role in adrenal development and function has not been established in vivo in the first half of gestation. In the prese
Publikováno v:
The Journal of clinical endocrinology and metabolism. 82(12)
The objective of the present study was to determine whether, in addition to the onset of chorionic somatomammotropin (CS) production previously shown to result from the morphological differentiation of cytotrophoblasts into syncytiotrophoblasts, ther
Publikováno v:
Endocrinology. 138(7)
Throughout the majority of intrauterine development, the primate fetal adrenal gland is comprised primarily of fetal zone cells and only late in gestation do definitive zone cells, which express the enzyme delta5-3beta-hydroxysteroid dehydrogenase/is