Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy

Autor: Ying Gong, Roel G. J. Klein Wolterink, Jianxiang Wang, Gerard M. J. Bos, Wilfred T. V. Germeraad

Publikováno v: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-35 (2021)

Abstract Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are considered as specialized immune cells that can be genetically modified to obtain capable effector cells for adoptive cellular treatment of cancer

Externí odkaz: https://doaj.org/article/6c31255476e94becb8ad5d79bda37f27

Rosuvastatin Enhances VSV-G Lentiviral Transduction of NK Cells via Upregulation of the Low-Density Lipoprotein Receptor

Autor: Ying Gong, Gerard M. J. Bos, Ian Janssen, Roel G. J. Klein Wolterink, Arjan J. Groot, Wilfred T. V. Germeraad

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy-Methods and Clinical Development, 17, 634-646. Nature Publishing Group
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 634-646 (2020)

Adoptive natural killer (NK) cell therapy is attaining promising clinical outcomes in recent years, but improvements are needed. Genetic modification of NK cells with a tumor antigen-specific receptor on their surface coupled to intracellular signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724894981c6afdce3e5ff4894ff0e3f7
http://europepmc.org/articles/PMC7150439

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Defucosylation of Tumor-Specific Humanized Anti-MUC1 Monoclonal Antibody Enhances NK Cell-Mediated Anti-Tumor Cell Cytotoxicity

Autor: Yvo F. Graus, Silvie Cloosen, Ying Gong, Valeriia Gulaia, Roel G. J. Klein Wolterink, Gerard M. J. Bos, Femke A I Ehlers, Lotte Wieten, Wilfred T. V. Germeraad

Publikováno v: Cancers, Vol 13, Iss 2579, p 2579 (2021)
Cancers
Volume 13
Issue 11
Cancers, 13(11):2579. Multidisciplinary Digital Publishing Institute (MDPI)

Simple Summary Antibodies with their high specificity to antigens have been widely used in cancer immunotherapy. Natural killer (NK) cells are a group of innate immune cells which have strong cytotoxicity against cancerous cells, virus infected cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b867b0428ae9d57c9c2baf3ac65ba29
https://www.mdpi.com/2072-6694/13/11/2579

Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit

Autor: Filipa, Cardoso, Roel G J, Klein Wolterink, Cristina, Godinho-Silva, Rita G, Domingues, Hélder, Ribeiro, Joaquim Alves, da Silva, Inês, Mahú, Ana I, Domingos, Henrique, Veiga-Fernandes

Publikováno v: Nature. 597(7876)

Signals from sympathetic neurons and immune cells regulate adipocytes and thereby contribute to fat tissue biology. Interactions between the nervous and immune systems have recently emerged as important regulators of host defence and inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::246887f97f0caff70ef3e20310f11e4a
https://pubmed.ncbi.nlm.nih.gov/34644555