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pro vyhledávání: '"G J, Fici"'
Publikováno v:
Amino acids. 14(1-3)
Dopa and related catecholamines and their degradation products have been demonstrated to have neurotoxic potential in a number of cellular and in vivo experiments. Several mechanisms have been hypothesized to be involved including generation of proox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45560aac2af079e67c75490f15e7d0e
https://pubmed.ncbi.nlm.nih.gov/9871460
https://pubmed.ncbi.nlm.nih.gov/9871460
Publikováno v:
Research communications in molecular pathology and pharmacology. 91(3)
Following CNS trauma or ischemia, peroxynitrite may be a toxic intermediate which forms in vivo when nitric oxide condenses with superoxide. Alone, peroxynitrite appears to directly react with aromatic and sulfhydryl nucleophiles. However, at physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4d37bfc5acfe56c64b2e63a8fa92f96
https://pubmed.ncbi.nlm.nih.gov/8829775
https://pubmed.ncbi.nlm.nih.gov/8829775
Publikováno v:
Research communications in molecular pathology and pharmacology. 87(3)
Peroxynitrite may be a physiologically relevant endogenous neurotoxin that forms following CNS trauma when excessive levels of NO and .O2 accumulate. Recently, peroxynitrite was found to inactivate the polyclonal antibody to cAMP. A feasibility study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::444b87467c82f8d677b51f55d4e609b2
https://pubmed.ncbi.nlm.nih.gov/7620829
https://pubmed.ncbi.nlm.nih.gov/7620829
Publikováno v:
Research communications in chemical pathology and pharmacology. 83(3)
Nitric oxide (NO) is made by NO synthase during the conversion of arginine to citrulline. Researchers have found that they can block the actions of excitotoxins by inhibiting NO synthase. Released from excitable cells during trauma, NO may react with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb213376554f07e1aaec182c445e65fe
https://pubmed.ncbi.nlm.nih.gov/8008974
https://pubmed.ncbi.nlm.nih.gov/8008974