Výsledky vyhledávání - "G J, Dougherty"

Alternative splicing as a novel of means of regulating the expression of therapeutic genes

Autor: Shona T. Dougherty, Gregory M. Hayes, Julie F. Dirks, Carmine Carpenito, Peter D Davis, G J Dougherty

Publikováno v: Cancer Gene Therapy. 9:133-141

In order to determine the potential of alternative splicing as a means of targeting the expression of therapeutic genes to tumor cells in vivo, a series of episomal plasmid-based "splice-activated gene expression" (pSAGE) vectors was generated, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e2fa16f165d97a8b53e1033d729338
https://doi.org/10.1038/sj.cgt.7700427

Zobrazit plný text záznamu

Alternatively spliced CD44 isoforms containing exon v10 promote cellular adhesion through the recognition of chondroitin sulfate-modified CD44

Autor: Roland K. Chiu, G J Dougherty, Shona T. Dougherty, Armin Droll, Carmine Carpenito, David L. Cooper

Publikováno v: Experimental Cell Research, 248(1), 314-21. HANLEY & BELFUS-ELSEVIER INC

Correlations have been noted between the expression of certain alternatively spliced CD44 isoforms and the metastatic propensity of various histologically distinct tumor cell types. The precise mechanism by which particular CD44 isoforms contribute t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf85f4c4140da946e62d7157351a0cf
https://doi.org/10.1006/excr.1999.4391

Zobrazit plný text záznamu

Radiation Response of Connexin43-Transfected Cells in Relation to the 'Contact Effect'

Autor: Christian C. G. Naus, Peggy L. Olive, G J Dougherty, Chenmei Luo, Susan H. MacPhail

Publikováno v: Experimental Cell Research. 234:225-232

Some cell lines grown for only two cell doublings as multicell spheroids develop a form of resistance to killing by ionizing radiation that has been called the “contact” effect. While our previous results have implicated a role for higher order c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddd8e105935ae49ba05c326dc1c7ea9
https://doi.org/10.1006/excr.1997.3613

Zobrazit plný text záznamu

CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages

Autor: S P Hart, G J Dougherty, C Haslett, I Dransfield

Publikováno v: The Journal of Immunology. 159:919-925

Phagocytosis of apoptotic neutrophil granulocytes by macrophages at inflammatory sites is an important determinant of the process by which inflammation resolves. We demonstrate that phagocytosis of apoptotic neutrophils, but not apoptotic lymphocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed0cd72888854fee81cfc3ab6e4d3ef7
https://doi.org/10.4049/jimmunol.159.2.919

Zobrazit plný text záznamu

Role of macrophage-colony-stimulating factor in regulating the accumulation and phenotype of tumor-associated macrophages

Autor: Shona T. Dougherty, G J Dougherty, William H. McBride, Connie J. Eaves

Publikováno v: Cancer Immunology, Immunotherapy. 44:165-172

In order to better define the role played by tumor-cell-derived macrophage-colony-stimulating factor (M-CSF) in regulating the recruitment and phenotype of tumor-associated macrophages, Polyoma large T-transformed fibroblastoid cell lines, derived fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c167cd40bb88bb52779202c15ea5ba3e
https://doi.org/10.1007/s002620050369

Zobrazit plný text záznamu

Diverse effects of anti‐CD44 antibodies on the stromal cell‐mediated support of normal but not leukaemic (CML) haemopoiesis in vitro

Autor: Connie J. Eaves, Allen C. Eaves, G J Dougherty, Saghi Ghaffari

Publikováno v: British Journal of Haematology. 97:22-28

We have identified three non-cross-reacting anti-human CD44 monoclonal antibodies that have significant positive or negative (or no) effects on normal human haemopoiesis in the long-term culture (LTC) system. These effects manifested as increases or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87a2e578ff238e71a92a0376c5da3ae
https://doi.org/10.1046/j.1365-2141.1997.d01-2139.x

Zobrazit plný text záznamu

Molecular mechanisms regulating TNF-α production by tumor-associated macrophages

Autor: Shona T. Dougherty, G J Dougherty, William H. McBride, Connie J. Eaves

Publikováno v: Cancer Letters. 111:27-37

The molecular mechanisms that regulate the production and/or functional activity of intratumoral tumor necrosis factor-alpha (TNF-alpha) remain poorly defined. To begin to address this issue we have examined the level of TNF-alpha mRNA and protein pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120b623056a729e18a584b169d194cee
https://doi.org/10.1016/s0304-3835(96)04490-4

Zobrazit plný text záznamu

Differentiation-associated changes in CD44 isoform expression during normal hematopoiesis and their alteration in chronic myeloid leukemia

Autor: S Ghaffari, G J Dougherty, Connie J. Eaves, Allen C. Eaves, Peter M. Lansdorp

Publikováno v: Blood. 86:2976-2985

CD44 is a widely expressed, multifunctional, cell-surface glycoprotein that has been implicated in the regulation of normal hematopoiesis. In addition, expression of particular isoforms of CD44 has been associated with malignant transformation and/or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bf034ef8a7d0f324f48af76431e7a08
https://doi.org/10.1182/blood.v86.8.2976.2976

Zobrazit plný text záznamu