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Protein Z-dependent protease inhibitor and protein Z in peripheral arterial disease patients

Autor: F, Sofi, F, Cesari, Y, Tu, G, Pratesi, R, Pulli, C, Pratesi, G F, Gensini, R, Abbate, S, Fedi, G J, Broze

Publikováno v: Journal of thrombosis and haemostasis : JTH. 7(5)

Summary Introduction: Protein Z is a vitamin K-dependent protein that serves as a cofactor for the inhibition of activated factor X by the serpin protein Z-dependent protease inhibitor (ZPI). Protein Z plasma levels have been shown to be reduced in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc89b596c4fdc869eac9710856172eac
https://pubmed.ncbi.nlm.nih.gov/19228280

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Recombinant lipoprotein-associated coagulation inhibitor inhibits tissue thromboplastin-induced intravascular coagulation in the rabbit

Autor: K C, Day, L C, Hoffman, M O, Palmier, K K, Kretzmer, M D, Huang, E Y, Pyla, E, Spokas, G J, Broze, T G, Warren, T C, Wun

Publikováno v: Blood. 76:1538-1545

Lipoprotein-associated coagulation inhibitor produces feed-back inhibition of tissue factor (tissue thromboplastin)-induced coagulation in the presence of factor Xa Recombinant lipoprotein-associated coagulation inhibitor (rLACI) was tested for its a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10315df4f2f3d6da6ec7f861261d8708
https://doi.org/10.1182/blood.v76.8.1538.bloodjournal7681538

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Comparison of cell-surface TFPIalpha and beta

Autor: O, Piro, G J, Broze

Publikováno v: Journal of thrombosis and haemostasis : JTH. 3(12)

Tissue factor pathway inhibitor (TFPI) is mainly produced by endothelial cells and alternative mRNA splicing generates two forms, TFPIalpha and TFPIbeta. A portion of expressed TFPI remains associated with the cell surface through both direct (TFPIbe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd1ff30990cc95e6aa02c4b725b0a291
https://pubmed.ncbi.nlm.nih.gov/16246254

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Protein Z-dependent regulation of coagulation

Autor: G J, Broze

Publikováno v: Thrombosis and haemostasis. 86(1)

Protein Z (PZ) is a 62 kDa vitamin K-dependent plasma protein that serves as a cofactor for the inhibition of factor Xa by protein Z-dependent protease inhibitor (ZPI). ZPI is a recently identified 72 kDa member of the serpin superfamily of proteinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad72bd33b64754859223ae09b4b8dbf2
https://pubmed.ncbi.nlm.nih.gov/11487045

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Mouse protein Z-dependent protease inhibitor cDNA

Autor: J, Zhang, G J, Broze

Publikováno v: Thrombosis and haemostasis. 85(5)

Protein Z-dependent protease inhibitor (ZPI) is plasma proteinase inhibitor in the serpin superfamily that produces rapid inhibition of factor Xa in the presence of phospholipids, Ca++ and protein Z (PZ). Mouse ZPI cDNA was isolated and cloned from m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b8127842f6555632d85aaa6eeb604f5
https://pubmed.ncbi.nlm.nih.gov/11372680

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Characterization of the protein Z-dependent protease inhibitor

Autor: X, Han, R, Fiehler, G J, Broze

Publikováno v: Blood. 96(9)

Protein Z-dependent protease inhibitor (ZPI) is a 72-kd member of the serpin superfamily of proteinase inhibitors that produces rapid inhibition of factor Xa in the presence of protein Z (PZ), procoagulant phospholipids, and Ca(++) (t(1/2) less than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae1714060c48bb14ea6497c0b5dc927e
https://pubmed.ncbi.nlm.nih.gov/11049983

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Tissue factor pathway inhibitor gene disruption

Autor: G J, Broze

Publikováno v: Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 9

Tissue factor pathway inhibitor (TFPI) is a trivalent Kunitz-type plasma proteinase inhibitor that regulates the initiation of coagulation by producing activated factor X (FXa)-dependent feedback inhibition of the catalytic complex of FVIIa and tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6197f1f0f24436e2b0b812786c44850
https://pubmed.ncbi.nlm.nih.gov/9819035

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Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice

Autor: Z F, Huang, D, Higuchi, N, Lasky, G J, Broze

Publikováno v: Blood. 90(3)

Tissue factor pathway inhibitor (TFPI) is a multivalent Kunitz-type proteinase inhibitor that directly inhibits factor Xa and, in a factor Xa-dependent fashion, produces feedback inhibition of the factor VIIa/TF catalytic complex responsible for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e1799aca90f37d3210d4355744011407
https://pubmed.ncbi.nlm.nih.gov/9242522

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Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma

Autor: G J, Broze, D A, Higuchi

Publikováno v: Blood. 88(10)

Coagulation is initiated by the binding of factor VIIa to tissue factor, with resultant limited factor IX and X activation and thrombin production. Owing to the feedback inhibition of the factor VIIa/tissue factor complex by tissue factor pathway inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67853e3f849c45e5481a9e0b27754134
https://pubmed.ncbi.nlm.nih.gov/8916945

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