Výsledky vyhledávání - "G J, Blackwell"

Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups

Autor: H. F. Hodson, V. S. Rose, G. J. Blackwell, A. J. Parke, D. A. Sawyer, R. M. Hyde, L. Tilling, Derek A. Demaine, S. Smith, L.G. Garland

Publikováno v: European Journal of Medicinal Chemistry. 31:347-358

Summary This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0be1117ef0058344cb2255c06d88174
https://doi.org/10.1016/0223-5234(96)89161-6

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Development of a Novel Series of Trialkoxyaryl Derivatives as Specific and Competitive Antagonists of Platelet Activating Factor

Autor: N. J. Cheesman, Demaine Da, M. A. Brockwell, D. A. Sawyer, H. F. Hodson, R. M. Beams, G. J. Blackwell, L.G. Garland, P. J. Islip, R. M. Hyde

Publikováno v: Journal of Medicinal Chemistry. 38:2130-2137

The synthesis and structure-activity relationship (SAR) analysis of a novel series of trialkoxyaryl derivatives, as specific and competitive inhibitors of platelet activating factor (PAF), are described. Molecular modeling comparisons of PAF with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6085352ac86bddc53256570ae7f34f8b
https://doi.org/10.1021/jm00012a012

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Role of potassium channels in the regulation of cytokine release from THP-1 cells

Autor: A. M. Deakin, G. J. Blackwell, A. N. Payne

Publikováno v: Agents and Actions. 41:C188-C190

The role of K+ channels in the regulation of cytokine release was investigated. Quinine, a non-selective K+ channel blocking agent inhibited both TNFα and IL-1β release but had non-specific effects on cell function. Glipizide and glibenclamide, inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ec35a66c97ee40904d3870736431281
https://doi.org/10.1007/bf01987632

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Akademický článek

Test Data Acquisition and Reduction

Autor: G. J. Blackwell Dip Math (Tech)

Publikováno v: Measurement + Control, Vol 2 (1969)

Externí odkaz: https://doaj.org/article/8727348ebc4a4e2e9c823a5bc58fcd65

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Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation

Autor: R J Flower, G J Blackwell

Publikováno v: Nature. 278:456-459

ASPIRIN prevents prostaglandin (PG) generation by directly inhibiting the cyclo-oxygenase enzyme responsible for PG biosynthesis1–3. In addition, there is now conclusive evidence that anti-inflammatory steroids can also prevent PG generation4–13.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a292e923cb110451899581b7582228
https://doi.org/10.1038/278456a0

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Genetic hypertension in rats is accompanied by a defect in renal prostaglandin catabolism

Autor: K. M. Mullane, Roderick J. Flower, J. C. McGiff, J. M. Armstrong, G. J. Blackwell, John R. Vane

Publikováno v: Nature. 260(5552)

Noradrenaline releases prostaglandins in the kidney, and in rats these augment rather than reduce vasoconstriction produced by the amine. Homogenates of kidneys of New Zealand rats inbred for hypertension exhibit lower prostaglandin inactivation by 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d724dcae9ba742a6d45dcda85eb183
https://pubmed.ncbi.nlm.nih.gov/1264220

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