Tumor-educated platelet blood tests for Non-Small Cell Lung Cancer detection and management

Autor: Mafalda Antunes-Ferreira, Silvia D’Ambrosi, Mohammad Arkani, Edward Post, Sjors G. J. G. In ‘t Veld, Jip Ramaker, Kenn Zwaan, Ece Demirel Kucukguzel, Laurine E. Wedekind, Arjan W. Griffioen, Mirjam Oude Egbrink, Marijke J. E. Kuijpers, Daan van den Broek, David P. Noske, Koen J. Hartemink, Siamack Sabrkhany, Idris Bahce, Nik Sol, Harm-Jan Bogaard, Danijela Koppers-Lalic, Myron G. Best, Thomas Wurdinger

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Liquid biopsy approaches offer a promising technology for early and minimally invasive cancer detection. Tumor-educated platelets (TEPs) have emerged as a promising liquid biopsy biosource for the detection of various cancer types. In this s

Externí odkaz: https://doaj.org/article/9358e61d08a441cdb79204397fabd108

Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study

Autor: Yue Gao, Chun-Jie Liu, Hua-Yi Li, Xiao-Ming Xiong, Gui-Ling Li, Sjors G J G In ‘t Veld, Guang-Yao Cai, Gui-Yan Xie, Shao-Qing Zeng, Yuan Wu, Jian-Hua Chi, Jia-Hao Liu, Qiong Zhang, Xiao-Fei Jiao, Lin-Li Shi, Wan-Rong Lu, Wei-Guo Lv, Xing-Sheng Yang, Jurgen M J Piek, Cornelis D de Kroon, C A R Lok, Anna Supernat, Sylwia Łapińska-Szumczyk, Anna Łojkowska, Anna J Żaczek, Jacek Jassem, Bakhos A Tannous, Nik Sol, Edward Post, Myron G Best, Bei-Hua Kong, Xing Xie, Ding Ma, Thomas Wurdinger, An-Yuan Guo, Qing-Lei Gao

Publikováno v: Gao, Y, Liu, C-J, Li, H-Y, Xiong, X-M, Li, G-L, in 't Veld, S G J G, Cai, G-Y, Xie, G-Y, Zeng, S-Q, Wu, Y, Chi, J-H, Liu, J-H, Zhang, Q, Jiao, X-F, Shi, L-L, Lu, W-R, Lv, W-G, Yang, X-S, Piek, J M J, de Kroon, C D, Lok, C A R, Supernat, A, Łapińska-Szumczyk, S, Łojkowska, A, Żaczek, A J, Jassem, J, Tannous, B A, Sol, N, Post, E, Best, M G, Kong, B-H, Xie, X, Ma, D, Wurdinger, T, Guo, A-Y & Gao, Q-L 2023, ' Platelet RNA enables accurate detection of ovarian cancer : an intercontinental, biomarker identification study ', Protein & cell, vol. 14, no. 6, pp. 433-447 . https://doi.org/10.1093/procel/pwac056
Protein & cell. Higher Education Press

Platelets are reprogrammed by cancer via a process called education, which favors cancer development. The transcriptional profile of tumor-educated platelets (TEPs) is skewed and therefore practicable for cancer detection. This intercontinental, hosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3501931432af99a06df56403d9512a8
https://doi.org/10.1093/procel/pwac056

Omics analysis of educated platelets in cancer and benign disease of the pancreas

Autor: Thomas Wurdinger, Thang V. Pham, Ilias Glogovitis, Giulia Mantini, Geert Kazemier, Connie R. Jimenez, Tessa Y S Le Large, Elisa Giovannetti, Rosita Paleckyte, Sjors G J G In 't Veld, Laura L. Meijer, Adam E Frampton, M. Capula, Danijela Koppers-Lalic, Sander R. Piersma, Luca Morelli

Publikováno v: Cancers
Volume 13
Issue 1
Cancers, Vol 13, Iss 66, p 66 (2021)
Cancers, 13(1):66, 1-20. Multidisciplinary Digital Publishing Institute (MDPI)
Mantini, G, Meijer, L L, Glogovitis, I, in ‘t Veld, S G J G, Paleckyte, R, Capula, M, le Large, T Y S, Morelli, L, Pham, T V, Piersma, S R, Frampton, A E, Jimenez, C R, Kazemier, G, Koppers-Lalic, D, Wurdinger, T & Giovannetti, E 2021, ' Omics analysis of educated platelets in cancer and benign disease of the pancreas ', Cancers, vol. 13, no. 1, 66, pp. 1-20 . https://doi.org/10.3390/cancers13010066

Pancreatic ductal adenocarcinoma (PDAC) is traditionally associated with thrombocytosis/hypercoagulation and novel insights on platelet-PDAC &ldquo
dangerous liaisons&rdquo
are warranted. Here we performed an integrative omics study investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec17835626efac2315ae308a437381c2
https://doi.org/10.3390/cancers13010066

imPlatelet classifier: image-converted RNA biomarker profiles enable blood-based cancer diagnostics

Autor: Krzysztof Pastuszak, Myron G. Best, Sjors G J G In 't Veld, Thomas Wurdinger, Anna Supernat, Tomasz Stokowy, Anna J. Żaczek, Anna Łojkowska, Jacek Jassem, Sylwia Łapińska-Szumczyk, Robert Różański

Publikováno v: Molecular oncology, 15(10), 2688-2701. Elsevier
Molecular Oncology
Pastuszak, K, Supernat, A, Best, M G, in 't Veld, S G J G, Łapińska-Szumczyk, S, Łojkowska, A, Różański, R, Żaczek, A J, Jassem, J, Würdinger, T & Stokowy, T 2021, ' imPlatelet classifier: image-converted RNA biomarker profiles enable blood-based cancer diagnostics ', Molecular oncology, vol. 15, no. 10, pp. 2688-2701 . https://doi.org/10.1002/1878-0261.13014
Molecular Oncology, Vol 15, Iss 10, Pp 2688-2701 (2021)

Liquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor‐educated platelets. Here, we developed the imPlatelet c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc863025f0c050dddf137cb090f4357b
https://research.vumc.nl/en/publications/7eaf15d3-6e46-4282-8888-709e2eeb3d67

RNA sequencing and swarm intelligence–enhanced classification algorithm development for blood-based disease diagnostics using spliced blood platelet RNA

Autor: Nik Sol, Sjors G J G In 't Veld, Thomas Wurdinger, Myron G. Best

Publikováno v: Best, M G, in ’t Veld, S G J G, Sol, N & Wurdinger, T 2019, ' RNA sequencing and swarm intelligence–enhanced classification algorithm development for blood-based disease diagnostics using spliced blood platelet RNA ', Nature Protocols, vol. 14, no. 4, pp. 1206-1234 . https://doi.org/10.1038/s41596-019-0139-5
Nature protocols, 14(4), 1206-1234. Nature Publishing Group
Nature Protocols, 14(4), 1206-1234. Nature Publishing Group

Blood-based diagnostics tests, using individual or panels of biomarkers, may revolutionize disease diagnostics and enable minimally invasive therapy monitoring. However, selection of the most relevant biomarkers from liquid biosources remains an imme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ceba9b2d503e83af1539396b591443
https://doi.org/10.1038/s41596-019-0139-5