Výsledky vyhledávání - "G I, Shulman"

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction

Autor: G, Boden, G I, Shulman

Publikováno v: European journal of clinical investigation. 32

Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart, liver and pancreas. However, chronically elevated plasma FFA appear to have pathophysiological consequences. Elevated FFA concentrations are linked with the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fc3fa16a3f03d9de0c5f8fcb6103d12
https://pubmed.ncbi.nlm.nih.gov/12028371

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Spectroscopic imaging of glutamate C4 turnover in human brain

Autor: J W, Pan, D T, Stein, F, Telang, J H, Lee, J, Shen, P, Brown, G, Cline, G F, Mason, G I, Shulman, D L, Rothman, H P, Hetherington

Publikováno v: Magnetic resonance in medicine. 44(5)

One-dimensional spectroscopic imaging of (13)C-4-glutamate turnover is performed in the human brain with a 6 cc nominal voxel resolution at 4T. Data were acquired with an indirect detection approach using a short spin echo single quantum (1)H-(13)C h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b69add10d5391fcbd880fbc1f947f919
https://pubmed.ncbi.nlm.nih.gov/11064400

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13C/31P NMR assessment of mitochondrial energy coupling in skeletal muscle of awake fed and fasted rats. Relationship with uncoupling protein 3 expression

Autor: B M, Jucker, J, Ren, S, Dufour, X, Cao, S F, Previs, K S, Cadman, G I, Shulman

Publikováno v: The Journal of biological chemistry. 275(50)

To examine the relationship between mitochondrial energy coupling in skeletal muscle and change in uncoupling protein 3 (UCP3) expression during the transition from the fed to fasted state, we used a novel noninvasive (31)P/(13)C NMR spectroscopic ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f222b9379f674356185be562045bd9ce
https://pubmed.ncbi.nlm.nih.gov/10995775

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Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

Autor: M D, Michael, R N, Kulkarni, C, Postic, S F, Previs, G I, Shulman, M A, Magnuson, C R, Kahn

Publikováno v: Molecular cell. 6(1)

The liver plays a central role in the control of glucose homeostasis and is subject to complex regulation by substrates, insulin, and other hormones. To investigate the effect of the loss of direct insulin action in liver, we have used the Cre-loxP s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::760a4c04924b9e81587ec7c74f246735
https://pubmed.ncbi.nlm.nih.gov/10949030

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